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The Public Health Exposome: A Population-Based, Exposure Science Approach to Health Disparities Research

Author

Listed:
  • Paul D. Juarez

    (Research Center on Health Disparities, Equity, and the Exposome, University of Tennessee Health Science Center, 66 N. Pauline, Memphis, TN 38105, USA
    These authors contributed equally to this work.)

  • Patricia Matthews-Juarez

    (Research Center on Health Disparities, Equity, and the Exposome, University of Tennessee Health Science Center, 66 N. Pauline, Memphis, TN 38105, USA
    These authors contributed equally to this work.)

  • Darryl B. Hood

    (Department of Environmental Health Sciences, College of Public Health, Ohio State University, Columbus, OH 43210, USA
    These authors contributed equally to this work.)

  • Wansoo Im

    (Vertices, Inc., 317 George Street 411, New Brunswick, NJ 08901, USA
    These authors contributed equally to this work.)

  • Robert S. Levine

    (Department of Family & Community Medicine, Meharry Medical College, Nashville, TN 37208, USA)

  • Barbara J. Kilbourne

    (Department of Sociology, Tennessee State University, Nashville, TN 37209, USA
    These authors contributed equally to this work.)

  • Michael A. Langston

    (Department of Electrical Engineering and Computer Science, University of Tennessee, Knoxville, TN 37996, USA)

  • Mohammad Z. Al-Hamdan

    (National Space Science and Technology Center, Universities Space Research Association, NASA Marshall Space Flight Center, Huntsville, AL 35805, USA)

  • William L. Crosson

    (National Space Science and Technology Center, Universities Space Research Association, NASA Marshall Space Flight Center, Huntsville, AL 35805, USA)

  • Maurice G. Estes

    (National Space Science and Technology Center, University of Alabama, Huntsville, AL 35805, USA)

  • Sue M. Estes

    (National Space Science and Technology Center, Universities Space Research Association, NASA Marshall Space Flight Center, Huntsville, AL 35805, USA)

  • Vincent K. Agboto

    (Department of Family & Community Medicine, Meharry Medical College, Nashville, TN 37208, USA)

  • Paul Robinson

    (Department of Ophthalmology, Charles R. Drew University of Medicine and Science, Los Angeles, CA 90059, USA)

  • Sacoby Wilson

    (Maryland Institute for Applied Environmental Health, School of Public Health, University of Maryland, College Park, MA 20742, USA)

  • Maureen Y. Lichtveld

    (Department of Global Environmental Health Sciences, School of Public Health and Tropical Medicine, Tulane University, 1440 Canal Street, New Orleans, LA 70112, USA
    These authors contributed equally to this work.)

Abstract

The lack of progress in reducing health disparities suggests that new approaches are needed if we are to achieve meaningful, equitable, and lasting reductions. Current scientific paradigms do not adequately capture the complexity of the relationships between environment, personal health and population level disparities. The public health exposome is presented as a universal exposure tracking framework for integrating complex relationships between exogenous and endogenous exposures across the lifespan from conception to death. It uses a social-ecological framework that builds on the exposome paradigm for conceptualizing how exogenous exposures “get under the skin”. The public health exposome approach has led our team to develop a taxonomy and bioinformatics infrastructure to integrate health outcomes data with thousands of sources of exogenous exposure, organized in four broad domains: natural, built, social, and policy environments. With the input of a transdisciplinary team, we have borrowed and applied the methods, tools and terms from various disciplines to measure the effects of environmental exposures on personal and population health outcomes and disparities, many of which may not manifest until many years later. As is customary with a paradigm shift, this approach has far reaching implications for research methods and design, analytics, community engagement strategies, and research training.

Suggested Citation

  • Paul D. Juarez & Patricia Matthews-Juarez & Darryl B. Hood & Wansoo Im & Robert S. Levine & Barbara J. Kilbourne & Michael A. Langston & Mohammad Z. Al-Hamdan & William L. Crosson & Maurice G. Estes &, 2014. "The Public Health Exposome: A Population-Based, Exposure Science Approach to Health Disparities Research," IJERPH, MDPI, vol. 11(12), pages 1-30, December.
  • Handle: RePEc:gam:jijerp:v:11:y:2014:i:12:p:12866-12895:d:43390
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    Cited by:

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    4. Stefano Canali, 2020. "What Is New about the Exposome? Exploring Scientific Change in Contemporary Epidemiology," IJERPH, MDPI, vol. 17(8), pages 1-9, April.
    5. Tonny J. Oyana & Patricia Matthews-Juarez & Stephania A. Cormier & Xiaoran Xu & Paul D. Juarez, 2015. "Using an External Exposome Framework to Examine Pregnancy-Related Morbidities and Mortalities: Implications for Health Disparities Research," IJERPH, MDPI, vol. 13(1), pages 1-14, December.
    6. Michael A. Langston & Robert S. Levine & Barbara J. Kilbourne & Gary L. Rogers & Anne D. Kershenbaum & Suzanne H. Baktash & Steven S. Coughlin & Arnold M. Saxton & Vincent K. Agboto & Darryl B. Hood &, 2014. "Scalable Combinatorial Tools for Health Disparities Research," IJERPH, MDPI, vol. 11(10), pages 1-25, October.
    7. Mary A. Fox & L. Elizabeth Brewer & Lawrence Martin, 2017. "An Overview of Literature Topics Related to Current Concepts, Methods, Tools, and Applications for Cumulative Risk Assessment (2007–2016)," IJERPH, MDPI, vol. 14(4), pages 1-28, April.
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