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Scalable Combinatorial Tools for Health Disparities Research

Author

Listed:
  • Michael A. Langston

    (Department of Electrical Engineering and Computer Science, University of Tennessee, Knoxville, TN 37996, USA)

  • Robert S. Levine

    (Department of Family and Community Medicine, Meharry Medical College, Nashville, TN 37208, USA)

  • Barbara J. Kilbourne

    (Department of Family and Community Medicine, Meharry Medical College, Nashville, TN 37208, USA)

  • Gary L. Rogers

    (National Institute for Computational Sciences, Oak Ridge National Laboratory, Oak Ridge, TN 37831, USA)

  • Anne D. Kershenbaum

    (Department of Public Health, University of Tennessee, Knoxville, TN 37996, USA)

  • Suzanne H. Baktash

    (Department of Electrical Engineering and Computer Science, University of Tennessee, Knoxville, TN 37996, USA)

  • Steven S. Coughlin

    (Department of Epidemiology, Emory University, Atlanta, GA 30322, USA)

  • Arnold M. Saxton

    (Department of Animal Science, Institute of Agriculture, University of Tennessee, Knoxville, TN 37996, USA)

  • Vincent K. Agboto

    (Department of Family and Community Medicine, Meharry Medical College, Nashville, TN 37208, USA)

  • Darryl B. Hood

    (Division of Environmental Health Sciences, College of Public Health, Ohio State University, Columbus, OH 43210, USA)

  • Maureen Y. Litchveld

    (Department of Global Environmental Health Sciences, Tulane University, New Orleans, LA 70112, USA)

  • Tonny J. Oyana

    (Research Center on Health Disparities, Equity, and the Exposome, University of Tennessee Health Science Center, Memphis, TN 38163, USA)

  • Patricia Matthews-Juarez

    (Research Center on Health Disparities, Equity, and the Exposome, University of Tennessee Health Science Center, Memphis, TN 38163, USA)

  • Paul D. Juarez

    (Research Center on Health Disparities, Equity, and the Exposome, University of Tennessee Health Science Center, Memphis, TN 38163, USA)

Abstract

Despite staggering investments made in unraveling the human genome, current estimates suggest that as much as 90% of the variance in cancer and chronic diseases can be attributed to factors outside an individual’s genetic endowment, particularly to environmental exposures experienced across his or her life course. New analytical approaches are clearly required as investigators turn to complicated systems theory and ecological, place-based and life-history perspectives in order to understand more clearly the relationships between social determinants, environmental exposures and health disparities. While traditional data analysis techniques remain foundational to health disparities research, they are easily overwhelmed by the ever-increasing size and heterogeneity of available data needed to illuminate latent gene x environment interactions. This has prompted the adaptation and application of scalable combinatorial methods, many from genome science research, to the study of population health. Most of these powerful tools are algorithmically sophisticated, highly automated and mathematically abstract. Their utility motivates the main theme of this paper, which is to describe real applications of innovative transdisciplinary models and analyses in an effort to help move the research community closer toward identifying the causal mechanisms and associated environmental contexts underlying health disparities. The public health exposome is used as a contemporary focus for addressing the complex nature of this subject.

Suggested Citation

  • Michael A. Langston & Robert S. Levine & Barbara J. Kilbourne & Gary L. Rogers & Anne D. Kershenbaum & Suzanne H. Baktash & Steven S. Coughlin & Arnold M. Saxton & Vincent K. Agboto & Darryl B. Hood &, 2014. "Scalable Combinatorial Tools for Health Disparities Research," IJERPH, MDPI, vol. 11(10), pages 1-25, October.
    • Handle: RePEc:gam:jijerp:v:11:y:2014:i:10:p:10419-10443:d:41043
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    References listed on IDEAS

    as
    1. Schwartz, S., 1994. "The fallacy of the ecological fallacy: The potential misuse of a concept and the consequences," American Journal of Public Health, American Public Health Association, vol. 84(5), pages 819-824.
    2. Paul D. Juarez & Patricia Matthews-Juarez & Darryl B. Hood & Wansoo Im & Robert S. Levine & Barbara J. Kilbourne & Michael A. Langston & Mohammad Z. Al-Hamdan & William L. Crosson & Maurice G. Estes &, 2014. "The Public Health Exposome: A Population-Based, Exposure Science Approach to Health Disparities Research," IJERPH, MDPI, vol. 11(12), pages 1-30, December.
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    6. Frederick Wong, 2003. "Efficient estimation of covariance selection models," Biometrika, Biometrika Trust, vol. 90(4), pages 809-830, December.
    7. Anne D. Kershenbaum & Michael A. Langston & Robert S. Levine & Arnold M. Saxton & Tonny J. Oyana & Barbara J. Kilbourne & Gary L. Rogers & Lisaann S. Gittner & Suzanne H. Baktash & Patricia Matthews-J, 2014. "Exploration of Preterm Birth Rates Using the Public Health Exposome Database and Computational Analysis Methods," IJERPH, MDPI, vol. 11(12), pages 1-21, November.
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    Cited by:

    1. Yuqin Jiao & Julie K. Bower & Wansoo Im & Nicholas Basta & John Obrycki & Mohammad Z. Al-Hamdan & Allison Wilder & Claire E. Bollinger & Tongwen Zhang & Luddie Sr. Hatten & Jerrie Hatten & Darryl B. H, 2015. "Application of Citizen Science Risk Communication Tools in a Vulnerable Urban Community," IJERPH, MDPI, vol. 13(1), pages 1-24, December.
    2. Anne D. Kershenbaum & Michael A. Langston & Robert S. Levine & Arnold M. Saxton & Tonny J. Oyana & Barbara J. Kilbourne & Gary L. Rogers & Lisaann S. Gittner & Suzanne H. Baktash & Patricia Matthews-J, 2014. "Exploration of Preterm Birth Rates Using the Public Health Exposome Database and Computational Analysis Methods," IJERPH, MDPI, vol. 11(12), pages 1-21, November.
    3. Paul D. Juarez & Patricia Matthews-Juarez & Darryl B. Hood & Wansoo Im & Robert S. Levine & Barbara J. Kilbourne & Michael A. Langston & Mohammad Z. Al-Hamdan & William L. Crosson & Maurice G. Estes &, 2014. "The Public Health Exposome: A Population-Based, Exposure Science Approach to Health Disparities Research," IJERPH, MDPI, vol. 11(12), pages 1-30, December.

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