IDEAS home Printed from https://ideas.repec.org/a/gam/jagris/v12y2022i9p1306-d897798.html
   My bibliography  Save this article

Comprehensive Profiling of Circular RNAs in Goat Dermal Papilla Cells and Prediction of Their Modulatory Roles in Hair Growth

Author

Listed:
  • Sen Ma

    (College of Animal Science and Technology, Henan Agricultural University, Zhengzhou 450002, China
    Henan Key Laboratory of Innovation and Utilization of Grassland Resources, Zhengzhou 450002, China
    Henan Engineering Research Center for Forage, Zhengzhou 450002, China)

  • Xiaochun Xu

    (Collaborative Innovation Center for Food Production and Safety, North Minzu University, Yinchuan 750000, China)

  • Xiaolong Wang

    (Key Laboratory of Animal Genetics, Breeding and Reproduction of Shaanxi Province, College of Animal Science and Technology, Northwest A&F University, Xianyang 712100, China)

  • Yuxin Yang

    (Key Laboratory of Animal Genetics, Breeding and Reproduction of Shaanxi Province, College of Animal Science and Technology, Northwest A&F University, Xianyang 712100, China)

  • Yinghua Shi

    (College of Animal Science and Technology, Henan Agricultural University, Zhengzhou 450002, China
    Henan Key Laboratory of Innovation and Utilization of Grassland Resources, Zhengzhou 450002, China
    Henan Engineering Research Center for Forage, Zhengzhou 450002, China)

  • Yulin Chen

    (Key Laboratory of Animal Genetics, Breeding and Reproduction of Shaanxi Province, College of Animal Science and Technology, Northwest A&F University, Xianyang 712100, China)

Abstract

Circular RNAs (circRNAs) are capable of finely modulating gene expression at transcriptional and post-transcriptional levels; however, their characters in dermal papilla cells (DPCs)—the signaling center of hair follicle—are still obscure. Herein, we established a comprehensive atlas of circRNAs in DPCs and their skin counterparts—dermal fibroblasts (DFs)—from cashmere goats. In terms of the results, a sum of 3706 circRNAs were bioinformatically identified. Subsequent analysis suggested that the detected transcripts exhibited several prominent genomic features, including exons as their main sources. Compared with DFs, 76 circRNAs significantly displayed higher abundances in goat DPCs, with 45 transcripts markedly exhibiting adverse trends ( p < 0.05). Furthermore, potential roles and underlying molecular mechanisms of circRNAs in goat DPCs were speculated through constructing their possible regulatory networks with mRNAs and microRNAs (miRNAs). We found that the circRNAs may serve as miRNA sponges to alleviate three hair growth-related functional genes ( HOXC8 , RSPO1 , and CCBE1 ) of DPCs from miRNAs-imposed post-transcriptional modulation, further facilitating two critical processes ( HOXC8 and RSPO1 : hair follicle stem cell activation; CCBE1 : follicular angiogenesis) closely involved in hair growth. In addition, we also speculated that two intron-derived circRNAs (chi_circ_0005569 and chi_circ_0005570) possibly affect the expression of their host gene CCBE1 at a transcriptional level in the nucleus. The above results demonstrated that circRNAs are abundantly expressed in goat DPCs, and certain circRNAs are potential participators in hair growth via the effects on the levels of related functional genes. Our study offers a preliminary clue for researchers hoping to untangle the roles of non-coding RNAs in hair growth.

Suggested Citation

  • Sen Ma & Xiaochun Xu & Xiaolong Wang & Yuxin Yang & Yinghua Shi & Yulin Chen, 2022. "Comprehensive Profiling of Circular RNAs in Goat Dermal Papilla Cells and Prediction of Their Modulatory Roles in Hair Growth," Agriculture, MDPI, vol. 12(9), pages 1-14, August.
    • Handle: RePEc:gam:jagris:v:12:y:2022:i:9:p:1306-:d:897798
    as

    Download full text from publisher

    File URL: https://www.mdpi.com/2077-0472/12/9/1306/pdf
    Download Restriction: no
    File URL: https://www.mdpi.com/2077-0472/12/9/1306/
    Download Restriction: no
    ---><---

    References listed on IDEAS

    as
    1. Sebastian Memczak & Marvin Jens & Antigoni Elefsinioti & Francesca Torti & Janna Krueger & Agnieszka Rybak & Luisa Maier & Sebastian D. Mackowiak & Lea H. Gregersen & Mathias Munschauer & Alexander Lo, 2013. "Circular RNAs are a large class of animal RNAs with regulatory potency," Nature, Nature, vol. 495(7441), pages 333-338, March.
    2. Lê, Sébastien & Josse, Julie & Husson, François, 2008. "FactoMineR: An R Package for Multivariate Analysis," Journal of Statistical Software, Foundation for Open Access Statistics, vol. 25(i01).
    3. Yvonne Tay & John Rinn & Pier Paolo Pandolfi, 2014. "The multilayered complexity of ceRNA crosstalk and competition," Nature, Nature, vol. 505(7483), pages 344-352, January.
    Full references (including those not matched with items on IDEAS)

    Citations

    Citations are extracted by the CitEc Project, subscribe to its RSS feed for this item.
    as


    Cited by:

    1. Heather Burrow & Michael Goddard, 2023. "Application of Genetics and Genomics in Livestock Production," Agriculture, MDPI, vol. 13(2), pages 1-4, February.

    Most related items

    These are the items that most often cite the same works as this one and are cited by the same works as this one.
    1. Federica Conte & Giulia Fiscon & Matteo Chiara & Teresa Colombo & Lorenzo Farina & Paola Paci, 2017. "Role of the long non-coding RNA PVT1 in the dysregulation of the ceRNA-ceRNA network in human breast cancer," PLOS ONE, Public Library of Science, vol. 12(2), pages 1-22, February.
    2. Karin Kauer & Sandra Pärnpuu & Liina Talgre & Viacheslav Eremeev & Anne Luik, 2021. "Soil Particulate and Mineral-Associated Organic Matter Increases in Organic Farming under Cover Cropping and Manure Addition," Agriculture, MDPI, vol. 11(9), pages 1-23, September.
    3. Surun, Clément & Drechsler, Martin, 2018. "Effectiveness of Tradable Permits for the Conservation of Metacommunities With Two Competing Species," Ecological Economics, Elsevier, vol. 147(C), pages 189-196.
    4. Jan Kluge & Sarah Lappöhn & Kerstin Plank, 2023. "Predictors of TFP growth in European countries," Empirica, Springer;Austrian Institute for Economic Research;Austrian Economic Association, vol. 50(1), pages 109-140, February.
    5. Navarro-Miró, D. & Iocola, I. & Persiani, A. & Blanco-Moreno, J.M. & Kristensen, H. Lakkenborg & Hefner, M. & Tamm, K. & Bender, I. & Védie, H. & Willekens, K. & Diacono, M. & Montemurro, F. & Sans, F, 2019. "Energy flows in European organic vegetable systems: Effects of the introduction and management of agroecological service crops," Energy, Elsevier, vol. 188(C).
    6. Alexander Platzer & Thomas Nussbaumer & Thomas Karonitsch & Josef S Smolen & Daniel Aletaha, 2019. "Analysis of gene expression in rheumatoid arthritis and related conditions offers insights into sex-bias, gene biotypes and co-expression patterns," PLOS ONE, Public Library of Science, vol. 14(7), pages 1-23, July.
    7. Baccar, Mariem & Raynal, Hélène & Sekhar, Muddu & Bergez, Jacques-Eric & Willaume, Magali & Casel, Pierre & Giriraj, P. & Murthy, Sanjeeva & Ruiz, Laurent, 2023. "Dynamics of crop category choices reveal strategies and tactics used by smallholder farmers in India to cope with unreliable water availability," Agricultural Systems, Elsevier, vol. 211(C).
    8. Aditi Sahu & Kivanc Kose & Lukas Kraehenbuehl & Candice Byers & Aliya Holland & Teguru Tembo & Anthony Santella & Anabel Alfonso & Madison Li & Miguel Cordova & Melissa Gill & Christi Fox & Salvador G, 2022. "In vivo tumor immune microenvironment phenotypes correlate with inflammation and vasculature to predict immunotherapy response," Nature Communications, Nature, vol. 13(1), pages 1-19, December.
    9. Junliang Yin & Xiaowen Han & Yongxing Zhu & Zhengwu Fang & Derong Gao & Dongfang Ma, 2022. "Transcriptome Profiles of Circular RNAs in Common Wheat during Fusarium Head Blight Disease," Data, MDPI, vol. 7(9), pages 1-8, August.
    10. Joy R. Petway & Yu-Pin Lin & Rainer F. Wunderlich, 2019. "Analyzing Opinions on Sustainable Agriculture: Toward Increasing Farmer Knowledge of Organic Practices in Taiwan-Yuanli Township," Sustainability, MDPI, vol. 11(14), pages 1-27, July.
    11. Pabitra Joshi & Guriqbal Singh Dhillon & Yaotian Gao & Amandeep Kaur & Justin Wheeler & Jianli Chen, 2024. "An Optimal Model to Improve Genomic Prediction for Protein Content and Test Weight in a Diverse Spring Wheat Panel," Agriculture, MDPI, vol. 14(3), pages 1-16, February.
    12. Nichiforel, Liviu & Keary, Kevin & Deuffic, Philippe & Weiss, Gerhard & Thorsen, Bo Jellesmark & Winkel, Georg & Avdibegović, Mersudin & Dobšinská, Zuzana & Feliciano, Diana & Gatto, Paola & Gorriz Mi, 2018. "How private are Europe’s private forests? A comparative property rights analysis," Land Use Policy, Elsevier, vol. 76(C), pages 535-552.
    13. Roopam Shukla & Ankit Agarwal & Kamna Sachdeva & Juergen Kurths & P. K. Joshi, 2019. "Climate change perception: an analysis of climate change and risk perceptions among farmer types of Indian Western Himalayas," Climatic Change, Springer, vol. 152(1), pages 103-119, January.
    14. Cholez, Celia & Pauly, Olivier & Mahdad, Maral & Mehrabi, Sepide & Giagnocavo, Cynthia & Bijman, Jos, 2023. "Heterogeneity of inter-organizational collaborations in agrifood chain sustainability-oriented innovations," Agricultural Systems, Elsevier, vol. 212(C).
    15. Loc, Ho Huu & Park, Edward & Thu, Tran Ngoc & Diep, Nguyen Thi Hong & Can, Nguyen Trong, 2021. "An enhanced analytical framework of participatory GIS for ecosystem services assessment applied to a Ramsar wetland site in the Vietnam Mekong Delta," Ecosystem Services, Elsevier, vol. 48(C).
    16. Florence Jacquet & A Aboul-Naga & Bernard Hubert, 2020. "The contribution of ARIMNet to address livestock systems resilience in the Mediterranean region," Post-Print hal-03625860, HAL.
    17. Juan García-Quezada & Ricardo Musule-Lagunes & José Angel Prieto-Ruíz & Daniel José Vega-Nieva & Artemio Carrillo-Parra, 2022. "Evaluation of Four Types of Kilns Used to Produce Charcoal from Several Tree Species in Mexico," Energies, MDPI, vol. 16(1), pages 1-22, December.
    18. Marika Vitali & Paolo Bosi & Elena Santacroce & Paolo Trevisi, 2021. "The multivariate approach identifies relationships between pre-slaughter factors, body lesions, ham defects and carcass traits in pigs," PLOS ONE, Public Library of Science, vol. 16(5), pages 1-14, May.
    19. Ariane F. Busso-Lopes & Leandro X. Neves & Guilherme A. Câmara & Daniela C. Granato & Marco Antônio M. Pretti & Henry Heberle & Fábio M. S. Patroni & Jamile Sá & Sami Yokoo & César Rivera & Romênia R., 2022. "Connecting multiple microenvironment proteomes uncovers the biology in head and neck cancer," Nature Communications, Nature, vol. 13(1), pages 1-24, December.
    20. Yu Dong & Qian Gao & Yong Chen & Zhao Zhang & Yanhua Du & Yuan Liu & Guangxiong Zhang & Shengli Li & Gaoyang Wang & Xiang Chen & Hong Liu & Leng Han & Youqiong Ye, 2023. "Identification of CircRNA signature associated with tumor immune infiltration to predict therapeutic efficacy of immunotherapy," Nature Communications, Nature, vol. 14(1), pages 1-15, December.

    More about this item

    Keywords

    circRNAs; DPCs; cashmere goats; HOXC8 ; RSPO1 ; CCBE1;
    All these keywords.

    JEL classification:

    Statistics

    Access and download statistics

    Corrections

    All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:gam:jagris:v:12:y:2022:i:9:p:1306-:d:897798. See general information about how to correct material in RePEc.

    If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

    If CitEc recognized a bibliographic reference but did not link an item in RePEc to it, you can help with this form .

    If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.

    For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: MDPI Indexing Manager (email available below). General contact details of provider: https://www.mdpi.com .

    Please note that corrections may take a couple of weeks to filter through the various RePEc services.

    IDEAS is a RePEc service. RePEc uses bibliographic data supplied by the respective publishers.