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The multilayered complexity of ceRNA crosstalk and competition

Author

Listed:
  • Yvonne Tay

    (Cancer Research Institute, Beth Israel Deaconess Cancer Center, Beth Israel Deaconess Medical Center, Harvard Medical School)

  • John Rinn

    (Beth Israel Deaconess Medical Center
    Harvard University
    Broad Institute of Massachusetts Institute of Technology and Harvard)

  • Pier Paolo Pandolfi

    (Cancer Research Institute, Beth Israel Deaconess Cancer Center, Beth Israel Deaconess Medical Center, Harvard Medical School)

Abstract

Recent reports have described an intricate interplay among diverse RNA species, including protein-coding messenger RNAs and non-coding RNAs such as long non-coding RNAs, pseudogenes and circular RNAs. These RNA transcripts act as competing endogenous RNAs (ceRNAs) or natural microRNA sponges — they communicate with and co-regulate each other by competing for binding to shared microRNAs, a family of small non-coding RNAs that are important post-transcriptional regulators of gene expression. Understanding this novel RNA crosstalk will lead to significant insight into gene regulatory networks and have implications in human development and disease.

Suggested Citation

  • Yvonne Tay & John Rinn & Pier Paolo Pandolfi, 2014. "The multilayered complexity of ceRNA crosstalk and competition," Nature, Nature, vol. 505(7483), pages 344-352, January.
    • Handle: RePEc:nat:nature:v:505:y:2014:i:7483:d:10.1038_nature12986
    DOI: 10.1038/nature12986
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    Cited by:

    1. Cong Wang & Xue Li & Binbin Xue & Changping Yu & Luoling Wang & Rilin Deng & Hui Liu & Zihao Chen & Yingdan Zhang & Suping Fan & Chaohui Zuo & Hungyu Sun & Haizhen Zhu & Jianli Wang & Songqing Tang, 2022. "RasGRP1 promotes the acute inflammatory response and restricts inflammation-associated cancer cell growth," Nature Communications, Nature, vol. 13(1), pages 1-17, December.
    2. Federica Conte & Giulia Fiscon & Matteo Chiara & Teresa Colombo & Lorenzo Farina & Paola Paci, 2017. "Role of the long non-coding RNA PVT1 in the dysregulation of the ceRNA-ceRNA network in human breast cancer," PLOS ONE, Public Library of Science, vol. 12(2), pages 1-22, February.
    3. Sen Ma & Xiaochun Xu & Xiaolong Wang & Yuxin Yang & Yinghua Shi & Yulin Chen, 2022. "Comprehensive Profiling of Circular RNAs in Goat Dermal Papilla Cells and Prediction of Their Modulatory Roles in Hair Growth," Agriculture, MDPI, vol. 12(9), pages 1-14, August.
    4. Junpeng Zhang & Taosheng Xu & Lin Liu & Wu Zhang & Chunwen Zhao & Sijing Li & Jiuyong Li & Nini Rao & Thuc Duy Le, 2020. "LMSM: A modular approach for identifying lncRNA related miRNA sponge modules in breast cancer," PLOS Computational Biology, Public Library of Science, vol. 16(4), pages 1-22, April.
    5. Ke Gong & Ting Xie & Yong Luo & Hui Guo & Jinlan Chen & Zhiping Tan & Yifeng Yang & Li Xie, 2021. "Comprehensive analysis of lncRNA biomarkers in kidney renal clear cell carcinoma by lncRNA-mediated ceRNA network," PLOS ONE, Public Library of Science, vol. 16(6), pages 1-24, June.

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