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An analytical model for genetic hitchhiking in the evolution of antimalarial drug resistance

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  • Schneider, Kristan A.
  • Kim, Yuseob

Abstract

We analytically study a deterministic model for the spread of drug resistance among human malaria parasites. The model incorporates all major characteristics of the complex malaria transmission cycle and accounts for the fact that only a fraction α of infected hosts receive drug treatment. Furthermore, the model incorporates that hosts can be co-infected. The number m of parasites co-infecting a host is either a constant or, more generally, follows a given frequency distribution.

Suggested Citation

  • Schneider, Kristan A. & Kim, Yuseob, 2010. "An analytical model for genetic hitchhiking in the evolution of antimalarial drug resistance," Theoretical Population Biology, Elsevier, vol. 78(2), pages 93-108.
    • Handle: RePEc:eee:thpobi:v:78:y:2010:i:2:p:93-108
    DOI: 10.1016/j.tpb.2010.06.005
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    1. John C. Wootton & Xiaorong Feng & Michael T. Ferdig & Roland A. Cooper & Jianbing Mu & Dror I. Baruch & Alan J. Magill & Xin-zhuan Su, 2002. "Genetic diversity and chloroquine selective sweeps in Plasmodium falciparum," Nature, Nature, vol. 418(6895), pages 320-323, July.
    2. Laxminarayan, Ramanan, 2003. "ACT Now or Later: The Economics of Malaria Resistance," RFF Working Paper Series dp-03-51, Resources for the Future.
    3. Robert W. Snow & Carlos A. Guerra & Abdisalan M. Noor & Hla Y. Myint & Simon I. Hay, 2005. "The global distribution of clinical episodes of Plasmodium falciparum malaria," Nature, Nature, vol. 434(7030), pages 214-217, March.
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