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Seasonal Intermittent Preventive Treatment for the Prevention of Anaemia and Malaria in Ghanaian Children: A Randomized, Placebo Controlled Trial

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  • Margaret Kweku
  • Dongmei Liu
  • Martin Adjuik
  • Fred Binka
  • Mahmood Seidu
  • Brian Greenwood
  • Daniel Chandramohan

Abstract

Background: Malaria and anaemia are the leading causes of morbidity and mortality in children in sub-Saharan Africa. We have investigated the effect of intermittent preventive treatment with sulphadoxine-pyrimethamine or artesunate plus amodiaquine on anaemia and malaria in children in an area of intense, prolonged, seasonal malaria transmission in Ghana. Methods: 2451 children aged 3–59 months from 30 villages were individually randomised to receive placebo or artesunate plus amodiaquine (AS+AQ) monthly or bimonthly, or sulphadoxine-pyrimethamine (SP) bimonthly over a period of six months. The primary outcome measures were episodes of anaemia (Hb 1 year old when they received IPTc compared to the placebo group. However the incidence of malaria in the post intervention period was higher in children who were

Suggested Citation

  • Margaret Kweku & Dongmei Liu & Martin Adjuik & Fred Binka & Mahmood Seidu & Brian Greenwood & Daniel Chandramohan, 2008. "Seasonal Intermittent Preventive Treatment for the Prevention of Anaemia and Malaria in Ghanaian Children: A Randomized, Placebo Controlled Trial," PLOS ONE, Public Library of Science, vol. 3(12), pages 1-12, December.
    • Handle: RePEc:plo:pone00:0004000
    DOI: 10.1371/journal.pone.0004000
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    References listed on IDEAS

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    1. Robert W. Snow & Carlos A. Guerra & Abdisalan M. Noor & Hla Y. Myint & Simon I. Hay, 2005. "The global distribution of clinical episodes of Plasmodium falciparum malaria," Nature, Nature, vol. 434(7030), pages 214-217, March.
    2. Cheikh Sokhna & Badara Cissé & El Hadj Bâ & Paul Milligan & Rachel Hallett & Colin Sutherland & Oumar Gaye & Denis Boulanger & Kirsten Simondon & François Simondon & Geoffrey Targett & Jo Lines & Bria, 2008. "A Trial of the Efficacy, Safety and Impact on Drug Resistance of Four Drug Regimens for Seasonal Intermittent Preventive Treatment for Malaria in Senegalese Children," PLOS ONE, Public Library of Science, vol. 3(1), pages 1-9, January.
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    1. Kalifa Bojang & Francis Akor & Ousman Bittaye & David Conway & Christian Bottomley & Paul Milligan & Brian Greenwood, 2010. "A Randomised Trial to Compare the Safety, Tolerability and Efficacy of Three Drug Combinations for Intermittent Preventive Treatment in Children," PLOS ONE, Public Library of Science, vol. 5(6), pages 1-9, June.
    2. Alassane Dicko & Abdoulbaki I Diallo & Intimbeye Tembine & Yahia Dicko & Niawanlou Dara & Youssoufa Sidibe & Gaoussou Santara & Halimatou Diawara & Toumani Conaré & Abdoulaye Djimde & Daniel Chandramo, 2011. "Intermittent Preventive Treatment of Malaria Provides Substantial Protection against Malaria in Children Already Protected by an Insecticide-Treated Bednet in Mali: A Randomised, Double-Blind, Placebo," PLOS Medicine, Public Library of Science, vol. 8(2), pages 1-14, February.
    3. Margaret Kweku & Jayne Webster & Martin Adjuik & Samuel Abudey & Brian Greenwood & Daniel Chandramohan, 2009. "Options for the Delivery of Intermittent Preventive Treatment for Malaria to Children: A Community Randomised Trial," PLOS ONE, Public Library of Science, vol. 4(9), pages 1-7, September.

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