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Seasonal Intermittent Preventive Treatment for the Prevention of Anaemia and Malaria in Ghanaian Children: A Randomized, Placebo Controlled Trial

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  • Margaret Kweku
  • Dongmei Liu
  • Martin Adjuik
  • Fred Binka
  • Mahmood Seidu
  • Brian Greenwood
  • Daniel Chandramohan

Abstract

Background: Malaria and anaemia are the leading causes of morbidity and mortality in children in sub-Saharan Africa. We have investigated the effect of intermittent preventive treatment with sulphadoxine-pyrimethamine or artesunate plus amodiaquine on anaemia and malaria in children in an area of intense, prolonged, seasonal malaria transmission in Ghana. Methods: 2451 children aged 3–59 months from 30 villages were individually randomised to receive placebo or artesunate plus amodiaquine (AS+AQ) monthly or bimonthly, or sulphadoxine-pyrimethamine (SP) bimonthly over a period of six months. The primary outcome measures were episodes of anaemia (Hb 1 year old when they received IPTc compared to the placebo group. However the incidence of malaria in the post intervention period was higher in children who were

Suggested Citation

  • Margaret Kweku & Dongmei Liu & Martin Adjuik & Fred Binka & Mahmood Seidu & Brian Greenwood & Daniel Chandramohan, 2008. "Seasonal Intermittent Preventive Treatment for the Prevention of Anaemia and Malaria in Ghanaian Children: A Randomized, Placebo Controlled Trial," PLOS ONE, Public Library of Science, vol. 3(12), pages 1-12, December.
    • Handle: RePEc:plo:pone00:0004000
    DOI: 10.1371/journal.pone.0004000
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