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A path integral approach to the Hodgkin–Huxley model

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  • Baravalle, Roman
  • Rosso, Osvaldo A.
  • Montani, Fernando

Abstract

To understand how single neurons process sensory information, it is necessary to develop suitable stochastic models to describe the response variability of the recorded spike trains. Spikes in a given neuron are produced by the synergistic action of sodium and potassium of the voltage-dependent channels that open or close the gates. Hodgkin and Huxley (HH) equations describe the ionic mechanisms underlying the initiation and propagation of action potentials, through a set of nonlinear ordinary differential equations that approximate the electrical characteristics of the excitable cell. Path integral provides an adequate approach to compute quantities such as transition probabilities, and any stochastic system can be expressed in terms of this methodology. We use the technique of path integrals to determine the analytical solution driven by a non-Gaussian colored noise when considering the HH equations as a stochastic system. The different neuronal dynamics are investigated by estimating the path integral solutions driven by a non-Gaussian colored noise q. More specifically we take into account the correlational structures of the complex neuronal signals not just by estimating the transition probability associated to the Gaussian approach of the stochastic HH equations, but instead considering much more subtle processes accounting for the non-Gaussian noise that could be induced by the surrounding neural network and by feedforward correlations. This allows us to investigate the underlying dynamics of the neural system when different scenarios of noise correlations are considered.

Suggested Citation

  • Baravalle, Roman & Rosso, Osvaldo A. & Montani, Fernando, 2017. "A path integral approach to the Hodgkin–Huxley model," Physica A: Statistical Mechanics and its Applications, Elsevier, vol. 486(C), pages 986-999.
  • Handle: RePEc:eee:phsmap:v:486:y:2017:i:c:p:986-999
    DOI: 10.1016/j.physa.2017.06.016
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    References listed on IDEAS

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    1. Montangie, Lisandro & Montani, Fernando, 2015. "Quantifying higher-order correlations in a neuronal pool," Physica A: Statistical Mechanics and its Applications, Elsevier, vol. 421(C), pages 388-400.
    2. Rosso, Osvaldo A. & Carpi, Laura C. & Saco, Patricia M. & Gómez Ravetti, Martín & Plastino, Angelo & Larrondo, Hilda A., 2012. "Causality and the entropy–complexity plane: Robustness and missing ordinal patterns," Physica A: Statistical Mechanics and its Applications, Elsevier, vol. 391(1), pages 42-55.
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    5. Montangie, Lisandro & Montani, Fernando, 2017. "Higher-order correlations in common input shapes the output spiking activity of a neural population," Physica A: Statistical Mechanics and its Applications, Elsevier, vol. 471(C), pages 845-861.
    6. Montani, Fernando & Phoka, Elena & Portesi, Mariela & Schultz, Simon R., 2013. "Statistical modelling of higher-order correlations in pools of neural activity," Physica A: Statistical Mechanics and its Applications, Elsevier, vol. 392(14), pages 3066-3086.
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    8. Montani, Fernando & Deleglise, Emilia B. & Rosso, Osvaldo A., 2014. "Efficiency characterization of a large neuronal network: A causal information approach," Physica A: Statistical Mechanics and its Applications, Elsevier, vol. 401(C), pages 58-70.
    9. O. A. Rosso & C. Masoller, 2009. "Detecting and quantifying temporal correlations in stochastic resonance via information theory measures," The European Physical Journal B: Condensed Matter and Complex Systems, Springer;EDP Sciences, vol. 69(1), pages 37-43, May.
    10. Lamberti, P.W & Martin, M.T & Plastino, A & Rosso, O.A, 2004. "Intensive entropic non-triviality measure," Physica A: Statistical Mechanics and its Applications, Elsevier, vol. 334(1), pages 119-131.
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    1. Liu, Yaru & Liu, Shenquan & Zhan, Feibiao & Zhang, Xiaohan, 2020. "Firing patterns of the modified Hodgkin–Huxley models subject to Taylor ’s formula," Physica A: Statistical Mechanics and its Applications, Elsevier, vol. 547(C).

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