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Bacterial cooperative organization under antibiotic stress

Author

Listed:
  • Ben-Jacob, Eshel
  • Cohen, Inon
  • Golding, Ido
  • Gutnick, David L.
  • Tcherpakov, Marianna
  • Helbing, Dirk
  • Ron, Ilan G.

Abstract

Bacteria have developed sophisticated modes of cooperative behavior to cope with unfavorable environmental conditions. Here we report the effect of antibiotic stress on the colonial development of Paenibacillus dendritiformis and P. vortex. We focus on the effect of co-trimoxazole on the colonial organization of P. dendritiformis. We find that the exposure to non-lethal concentrations of antibiotic leads to dramatic changes in the colonial growth patterns. Branching, tip-splitting patterns are affected by reduction in the colonial fractal dimension from Df=2.0 to 1.7, appearance of pronounced weak chirality and pronounced radial orientation of the growth. We combine the experimental observations with numerical studies of both discrete and continuous generic models to reveal the causes for the modifications in the patterns. We conclude that the bacteria adjust their chemotactic signaling together with variations in the bacteria length and increase in the metabolic load.

Suggested Citation

  • Ben-Jacob, Eshel & Cohen, Inon & Golding, Ido & Gutnick, David L. & Tcherpakov, Marianna & Helbing, Dirk & Ron, Ilan G., 2000. "Bacterial cooperative organization under antibiotic stress," Physica A: Statistical Mechanics and its Applications, Elsevier, vol. 282(1), pages 247-282.
    • Handle: RePEc:eee:phsmap:v:282:y:2000:i:1:p:247-282
    DOI: 10.1016/S0378-4371(00)00093-5
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    References listed on IDEAS

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    1. Golding, Ido & Kozlovsky, Yonathan & Cohen, Inon & Ben-Jacob, Eshel, 1998. "Studies of bacterial branching growth using reaction–diffusion models for colonial development," Physica A: Statistical Mechanics and its Applications, Elsevier, vol. 260(3), pages 510-554.
    2. Matsushita, Mitsugu & Fujikawa, Hiroshi, 1990. "Diffusion-limited growth in bacterial colony formation," Physica A: Statistical Mechanics and its Applications, Elsevier, vol. 168(1), pages 498-506.
    3. Ben-Jacob, Eshel & Shmueli, Haim & Shochet, Ofer & Tenenbaum, Adam, 1992. "Adaptive self-organization during growth of bacterial colonies," Physica A: Statistical Mechanics and its Applications, Elsevier, vol. 187(3), pages 378-424.
    4. Ben-Jacob, Eshel & Tenenbaum, Adam & Shochet, Ofer & Avidan, Orna, 1994. "Holotransformations of bacterial colonies and genome cybernetics," Physica A: Statistical Mechanics and its Applications, Elsevier, vol. 202(1), pages 1-47.
    5. Matsushita, M. & Wakita, J. & Itoh, H. & Ràfols, I. & Matsuyama, T. & Sakaguchi, H. & Mimura, M., 1998. "Interface growth and pattern formation in bacterial colonies," Physica A: Statistical Mechanics and its Applications, Elsevier, vol. 249(1), pages 517-524.
    6. Ben-Jacob, Eshel & Cohen, Inon & Czirók, András & Vicsek, Tamás & Gutnick, David L., 1997. "Chemomodulation of cellular movement, collective formation of vortices by swarming bacteria, and colonial development," Physica A: Statistical Mechanics and its Applications, Elsevier, vol. 238(1), pages 181-197.
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    Cited by:

    1. Leyva, J. Francisco & Málaga, Carlos & Plaza, Ramón G., 2013. "The effects of nutrient chemotaxis on bacterial aggregation patterns with non-linear degenerate cross diffusion," Physica A: Statistical Mechanics and its Applications, Elsevier, vol. 392(22), pages 5644-5662.
    2. Cohen, Inon & Ron, Ilan G & Ben-Jacob, Eshel, 2000. "From branching to nebula patterning during colonial development of the Paenibacillus alvei bacteria," Physica A: Statistical Mechanics and its Applications, Elsevier, vol. 286(1), pages 321-336.
    3. Frey, Erwin, 2010. "Evolutionary game theory: Theoretical concepts and applications to microbial communities," Physica A: Statistical Mechanics and its Applications, Elsevier, vol. 389(20), pages 4265-4298.

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