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Bursts of sectors in expanding bacterial colonies as a possible model for tumor growth and metastases

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  • Ron, Ilan G.
  • Golding, Ido
  • Lifsitz-Mercer, Beatrice
  • Ben-Jacob, Eshel

Abstract

All kinds of hypotheses have been proposed to explain the mechanism of tumorigenesis. Up until now, we have not had any generally acknowledged model that helps us understand the process. However, it is well accepted that cancer development and progression is dictated by a series of alterations in genes such as oncogenes, tumor suppressor genes, DNA replication genes and others. Segregation of cell populations is a key question in evolution theory. One important aspect when observing cell proliferation in general or bacterial colonies in particular is the relation between spatial organization and the composition of the populations. Here we study a specific example—sectors in expanding bacterial colonies. Such sectors are spatially segregated sub-populations of mutants. Bursts of sectors are observed during compact growth and during branching growth. For theoretical studies of these bursts we employ two mathematical models. Using these models we investigate the amount of segregation achieved by a neutral mutation, as well as by mutations having some advantage over the wild type.

Suggested Citation

  • Ron, Ilan G. & Golding, Ido & Lifsitz-Mercer, Beatrice & Ben-Jacob, Eshel, 2003. "Bursts of sectors in expanding bacterial colonies as a possible model for tumor growth and metastases," Physica A: Statistical Mechanics and its Applications, Elsevier, vol. 320(C), pages 485-496.
    • Handle: RePEc:eee:phsmap:v:320:y:2003:i:c:p:485-496
    DOI: 10.1016/S0378-4371(02)01547-9
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    References listed on IDEAS

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    1. Golding, Ido & Kozlovsky, Yonathan & Cohen, Inon & Ben-Jacob, Eshel, 1998. "Studies of bacterial branching growth using reaction–diffusion models for colonial development," Physica A: Statistical Mechanics and its Applications, Elsevier, vol. 260(3), pages 510-554.
    2. Ben-Jacob, Eshel & Shmueli, Haim & Shochet, Ofer & Tenenbaum, Adam, 1992. "Adaptive self-organization during growth of bacterial colonies," Physica A: Statistical Mechanics and its Applications, Elsevier, vol. 187(3), pages 378-424.
    3. David A. Kessler & Herbert Levine, 1998. "Fluctuation-induced diffusive instabilities," Nature, Nature, vol. 394(6693), pages 556-558, August.
    4. Ben-Jacob, Eshel & Tenenbaum, Adam & Shochet, Ofer & Avidan, Orna, 1994. "Holotransformations of bacterial colonies and genome cybernetics," Physica A: Statistical Mechanics and its Applications, Elsevier, vol. 202(1), pages 1-47.
    5. Ben-Jacob, Eshel & Cohen, Inon & Czirók, András & Vicsek, Tamás & Gutnick, David L., 1997. "Chemomodulation of cellular movement, collective formation of vortices by swarming bacteria, and colonial development," Physica A: Statistical Mechanics and its Applications, Elsevier, vol. 238(1), pages 181-197.
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