IDEAS home Printed from https://ideas.repec.org/a/eee/ecomod/v475y2023ics030438002200285x.html
   My bibliography  Save this article

Using the standard DEB animal model for toxicokinetic-toxicodynamic analysis

Author

Listed:
  • Jager, Tjalling
  • Goussen, Benoit
  • Gergs, André

Abstract

Toxicokinetic-toxicodynamic (TKTD) models are essential tools to close the gap between laboratory toxicity tests and impacts on individuals under field conditions. For sub-lethal effects on life-history traits, dynamic energy budget (DEB) theory provides a solid basis for TKTD modelling. Various DEB-based TKTD models have been presented, ranging from complex and comprehensive to simple and reduced. Here we present a complete and up-to-date model formulation at the complex end of the range. The basic part of the model, governing the life cycle of the species without toxicant stress, is formed by the standard DEB animal model. This part can directly use the species-specific model parameters from the add-my-pet (AmP) library. Additionally, we cover one extension of the standard model with metabolic acceleration for some time after birth (the abj-model). The basic DEB model is augmented by a TKTD model that explicitly considers damage as driving force for the toxic effects, and which considers various feedbacks from life-history traits to damage dynamics (e.g., dilution by growth). Several choices are needed in this linkage, which are made explicit. A Matlab-based toolbox is presented to support the model analyses, which is illustrated with a case study for the springtail Folsomia candida exposed to chlorpyrifos in food.

Suggested Citation

  • Jager, Tjalling & Goussen, Benoit & Gergs, André, 2023. "Using the standard DEB animal model for toxicokinetic-toxicodynamic analysis," Ecological Modelling, Elsevier, vol. 475(C).
    • Handle: RePEc:eee:ecomod:v:475:y:2023:i:c:s030438002200285x
    DOI: 10.1016/j.ecolmodel.2022.110187
    as

    Download full text from publisher

    File URL: http://www.sciencedirect.com/science/article/pii/S030438002200285X
    Download Restriction: Full text for ScienceDirect subscribers only
    File URL: https://libkey.io/10.1016/j.ecolmodel.2022.110187?utm_source=ideas
    LibKey link: if access is restricted and if your library uses this service, LibKey will redirect you to where you can use your library subscription to access this item
    ---><---

    As the access to this document is restricted, you may want to search for a different version of it.

    References listed on IDEAS

    as
    1. Jager, Tjalling & Zimmer, Elke I., 2012. "Simplified Dynamic Energy Budget model for analysing ecotoxicity data," Ecological Modelling, Elsevier, vol. 225(C), pages 74-81.
    2. Jager, Tjalling, 2020. "Revisiting simplified DEBtox models for analysing ecotoxicity data," Ecological Modelling, Elsevier, vol. 416(C).
    Full references (including those not matched with items on IDEAS)

    Most related items

    These are the items that most often cite the same works as this one and are cited by the same works as this one.
    1. Matyja, Konrad, 2023. "Standard dynamic energy budget model parameter sensitivity," Ecological Modelling, Elsevier, vol. 478(C).
    2. Mounier, Florence & Loizeau, Véronique & Pecquerie, Laure & Drouineau, Hilaire & Labadie, Pierre & Budzinski, Hélène & Lobry, Jérémy, 2020. "Dietary bioaccumulation of persistent organic pollutants in the common sole Solea solea in the context of global change. Part 2: Sensitivity of juvenile growth and contamination to toxicokinetic param," Ecological Modelling, Elsevier, vol. 431(C).
    3. Lamonica, Dominique & Herbach, Ulysse & Orias, Frédéric & Clément, Bernard & Charles, Sandrine & Lopes, Christelle, 2016. "Mechanistic modelling of daphnid-algae dynamics within a laboratory microcosm," Ecological Modelling, Elsevier, vol. 320(C), pages 213-230.
    4. Jager, Tjalling, 2020. "Revisiting simplified DEBtox models for analysing ecotoxicity data," Ecological Modelling, Elsevier, vol. 416(C).
    5. Johnston, A.S.A. & Hodson, M.E. & Thorbek, P. & Alvarez, T. & Sibly, R.M., 2014. "An energy budget agent-based model of earthworm populations and its application to study the effects of pesticides," Ecological Modelling, Elsevier, vol. 280(C), pages 5-17.
    6. Jager, Tjalling & Salaberria, Iurgi & Hansen, Bjørn Henrik, 2015. "Capturing the life history of the marine copepod Calanus sinicus into a generic bioenergetics framework," Ecological Modelling, Elsevier, vol. 299(C), pages 114-120.
    7. Accolla, Chiara & Vaugeois, Maxime & Rueda-Cediel, Pamela & Moore, Adrian & Marques, Gonçalo M. & Marella, Purvaja & Forbes, Valery E., 2020. "DEB-tox and Data Gaps: Consequences for individual-level outputs," Ecological Modelling, Elsevier, vol. 431(C).
    8. Palamara, Gian Marco & Dennis, Stuart R. & Haenggi, Corinne & Schuwirth, Nele & Reichert, Peter, 2022. "Investigating the effect of pesticides on Daphnia population dynamics by inferring structure and parameters of a stochastic model," Ecological Modelling, Elsevier, vol. 472(C).
    9. Kooijman, S.A.L.M., 2024. "Ways to reduce or avoid juvenile-driven cycles in individual-based population models," Ecological Modelling, Elsevier, vol. 490(C).
    10. Jager, Tjalling & Barsi, Alpar & Hamda, Natnael T. & Martin, Benjamin T. & Zimmer, Elke I. & Ducrot, Virginie, 2014. "Dynamic energy budgets in population ecotoxicology: Applications and outlook," Ecological Modelling, Elsevier, vol. 280(C), pages 140-147.
    11. Hamda, Natnael T. & Martin, Benjamin & Poletto, Jamilynn B. & Cocherell, Dennis E. & Fangue, Nann A. & Van Eenennaam, Joel & Mora, Ethan A. & Danner, Eric, 2019. "Applying a simplified energy-budget model to explore the effects of temperature and food availability on the life history of green sturgeon (Acipenser medirostris)," Ecological Modelling, Elsevier, vol. 395(C), pages 1-10.

    Corrections

    All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:eee:ecomod:v:475:y:2023:i:c:s030438002200285x. See general information about how to correct material in RePEc.

    If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

    If CitEc recognized a bibliographic reference but did not link an item in RePEc to it, you can help with this form .

    If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.

    For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: Catherine Liu (email available below). General contact details of provider: http://www.journals.elsevier.com/ecological-modelling .

    Please note that corrections may take a couple of weeks to filter through the various RePEc services.

    IDEAS is a RePEc service. RePEc uses bibliographic data supplied by the respective publishers.