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A semiparametric nonlinear mixed-effects model with non-ignorable missing data and measurement errors for HIV viral data

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  • Liu, Wei
  • Wu, Lang

Abstract

Semiparametric nonlinear mixed-effects (NLME) models are very flexible in modeling long-term HIV viral dynamics. In practice, statistical analyses are often complicated due to measurement errors and missing data in covariates and non-ignorable missing data in the responses. We consider likelihood methods which simultaneously address measurement error and missing data problems. A real dataset is analyzed in detail, and a simulation study is conducted to evaluate the methods.

Suggested Citation

  • Liu, Wei & Wu, Lang, 2008. "A semiparametric nonlinear mixed-effects model with non-ignorable missing data and measurement errors for HIV viral data," Computational Statistics & Data Analysis, Elsevier, vol. 53(1), pages 112-122, September.
    • Handle: RePEc:eee:csdana:v:53:y:2008:i:1:p:112-122
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    References listed on IDEAS

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    1. Vonesh E. F. & Wang H. & Nie L. & Majumdar D., 2002. "Conditional Second-Order Generalized Estimating Equations for Generalized Linear and Nonlinear Mixed-Effects Models," Journal of the American Statistical Association, American Statistical Association, vol. 97, pages 271-283, March.
    2. John A. Rice & Colin O. Wu, 2001. "Nonparametric Mixed Effects Models for Unequally Sampled Noisy Curves," Biometrics, The International Biometric Society, vol. 57(1), pages 253-259, March.
    3. Ke C. & Wang Y., 2001. "Semiparametric Nonlinear Mixed-Effects Models and Their Applications," Journal of the American Statistical Association, American Statistical Association, vol. 96, pages 1272-1298, December.
    4. Wei Liu & Lang Wu, 2007. "Simultaneous Inference for Semiparametric Nonlinear Mixed-Effects Models with Covariate Measurement Errors and Missing Responses," Biometrics, The International Biometric Society, vol. 63(2), pages 342-350, June.
    5. Wu L., 2002. "A Joint Model for Nonlinear Mixed-Effects Models With Censoring and Covariates Measured With Error, With Application to AIDS Studies," Journal of the American Statistical Association, American Statistical Association, vol. 97, pages 955-964, December.
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    Cited by:

    1. Ana Arribas-Gil & Rolando De la Cruz & Emilie Lebarbier & Cristian Meza, 2015. "Classification of longitudinal data through a semiparametric mixed-effects model based on lasso-type estimators," Biometrics, The International Biometric Society, vol. 71(2), pages 333-343, June.
    2. Jurecková, Jana & Picek, Jan & Saleh, A.K.Md. Ehsanes, 2010. "Rank tests and regression rank score tests in measurement error models," Computational Statistics & Data Analysis, Elsevier, vol. 54(12), pages 3108-3120, December.

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