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A growth mixture Tobit model: application to AIDS studies

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  • Getachew A. Dagne

Abstract

This paper presents an alternative analysis approach to modeling data where a lower detection limit (LOD) and unobserved population heterogeneity exist in a longitudinal data set. Longitudinal data on viral loads in HIV/AIDS studies, for instance, show strong positive skewness and left-censoring. Normalizing such data using a logarithmic transformation seems to be unsuccessful. An alternative to such a transformation is to use a finite mixture model which is suitable for analyzing data which have skewed or multi-modal distributions. There is little work done to simultaneously take into account these features of longitudinal data. This paper develops a growth mixture Tobit model that deals with a LOD and heterogeneity among growth trajectories. The proposed methods are illustrated using simulated and real data from an AIDS clinical study.

Suggested Citation

  • Getachew A. Dagne, 2016. "A growth mixture Tobit model: application to AIDS studies," Journal of Applied Statistics, Taylor & Francis Journals, vol. 43(7), pages 1174-1185, July.
    • Handle: RePEc:taf:japsta:v:43:y:2016:i:7:p:1174-1185
    DOI: 10.1080/02664763.2015.1092114
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    1. Murray Aitkin, 1999. "A General Maximum Likelihood Analysis of Variance Components in Generalized Linear Models," Biometrics, The International Biometric Society, vol. 55(1), pages 117-128, March.
    2. Amemiya, Takeshi, 1984. "Tobit models: A survey," Journal of Econometrics, Elsevier, vol. 24(1-2), pages 3-61.
    3. Wendelin Schnedler, 2005. "Likelihood Estimation for Censored Random Vectors," Econometric Reviews, Taylor & Francis Journals, vol. 24(2), pages 195-217.
    4. James P. Hughes, 1999. "Mixed Effects Models with Censored Data with Application to HIV RNA Levels," Biometrics, The International Biometric Society, vol. 55(2), pages 625-629, June.
    5. Bengt Muthén & Kerby Shedden, 1999. "Finite Mixture Modeling with Mixture Outcomes Using the EM Algorithm," Biometrics, The International Biometric Society, vol. 55(2), pages 463-469, June.
    6. repec:awi:wpaper:0417 is not listed on IDEAS
    7. Wu L., 2002. "A Joint Model for Nonlinear Mixed-Effects Models With Censoring and Covariates Measured With Error, With Application to AIDS Studies," Journal of the American Statistical Association, American Statistical Association, vol. 97, pages 955-964, December.
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