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Dynamic transition on the seizure-like neuronal activity by astrocytic calcium channel block

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  • Li, Jiajia
  • Wang, Rong
  • Du, Mengmeng
  • Tang, Jun
  • Wu, Ying

Abstract

The involvement of astrocytes in neuronal firing dynamics is becoming increasingly evident. In this study, we used a classical hippocampal tripartite synapse model consisting of soma-dendrite coupled neuron models and a Hodgkin–Huxley-like astrocyte model, to investigate the seizure-like firing in the somatic neuron induced by the over-expressed neuronal N-methyl-d-aspartate (NMDA) receptors. Based on this model, we further investigated the effect of the astrocytic channel block on the neuronal firing through a bifurcation analysis. Results show that blocking inositol-1,4,5-triphosphate(IP3)-dependent calcium channel in astrocytes efficiently suppresses the astrocytic calcium oscillation, which in turn suppresses the seizure-like firing in the neuron.

Suggested Citation

  • Li, Jiajia & Wang, Rong & Du, Mengmeng & Tang, Jun & Wu, Ying, 2016. "Dynamic transition on the seizure-like neuronal activity by astrocytic calcium channel block," Chaos, Solitons & Fractals, Elsevier, vol. 91(C), pages 702-708.
    • Handle: RePEc:eee:chsofr:v:91:y:2016:i:c:p:702-708
    DOI: 10.1016/j.chaos.2016.08.009
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    References listed on IDEAS

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    Cited by:

    1. Zhou, Ping & Yao, Zhao & Ma, Jun & Zhu, Zhigang, 2021. "A piezoelectric sensing neuron and resonance synchronization between auditory neurons under stimulus," Chaos, Solitons & Fractals, Elsevier, vol. 145(C).
    2. Li, Xiang & Zhang, Suxia & Liu, Xijun & Wang, Xiaojing & Zhou, Anqi & Liu, Peng, 2018. "Important role of MAMs in bifurcation and coherence resonance of calcium oscillations," Chaos, Solitons & Fractals, Elsevier, vol. 106(C), pages 131-140.
    3. Xiao, Fangli & Fu, Ziying & Jia, Ya & Yang, Lijian, 2023. "Resonance effects in neuronal-astrocyte model with ion channel blockage," Chaos, Solitons & Fractals, Elsevier, vol. 166(C).
    4. Yu, Yangyang & Yuan, Zhixuan & Li, Jiajia & Wu, Ying, 2023. "Dynamic analysis of epileptic seizures caused by energy failure after ischemic stroke," Chaos, Solitons & Fractals, Elsevier, vol. 176(C).

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