IDEAS home Printed from https://ideas.repec.org/a/eee/chsofr/v157y2022ics0960077922001321.html
   My bibliography  Save this article

Hopf bifurcation and chaos of tumor-Lymphatic model with two time delays

Author

Listed:
  • Wang, Jingnan
  • Shi, Hongbin
  • Xu, Li
  • Zang, Lu

Abstract

In this paper, a tumor and Lymphatic immune system interaction model with two time delays is discussed in which the delays describe the proliferation of tumor cells and the transmission from immature T lymphocytes to mature T lymphocytes respectively. Conditions for the asymptotic stability of the equilibrium and the existence of Hopf bifurcations are obtained by analyzing the roots of a characteristic equation. The computing formulas for the stability and the direction of the Hopf bifurcating periodic solutions are given. Numerical simulation show that different values of time delays can generate different behaviors, including the stable-state, the periodic oscillation and the chaotic attractors, as well as the coexistence of two periodic oscillations. These theoretical and numerical results not only can be useful for explaining the occurrence of chaotic attractors, but also can help for understanding the biomedical significance corresponding to the interaction dynamics of tumor cells and T lymphocytes.

Suggested Citation

  • Wang, Jingnan & Shi, Hongbin & Xu, Li & Zang, Lu, 2022. "Hopf bifurcation and chaos of tumor-Lymphatic model with two time delays," Chaos, Solitons & Fractals, Elsevier, vol. 157(C).
    • Handle: RePEc:eee:chsofr:v:157:y:2022:i:c:s0960077922001321
    DOI: 10.1016/j.chaos.2022.111922
    as

    Download full text from publisher

    File URL: http://www.sciencedirect.com/science/article/pii/S0960077922001321
    Download Restriction: Full text for ScienceDirect subscribers only
    File URL: https://libkey.io/10.1016/j.chaos.2022.111922?utm_source=ideas
    LibKey link: if access is restricted and if your library uses this service, LibKey will redirect you to where you can use your library subscription to access this item
    ---><---

    As the access to this document is restricted, you may want to search for a different version of it.

    References listed on IDEAS

    as
    1. De Cesare, Luigi & Sportelli, Mario, 2020. "Stability and direction of Hopf bifurcations of a cyclical growth model with two-time delays and one-delay dependent coefficients," Chaos, Solitons & Fractals, Elsevier, vol. 140(C).
    2. Li, Kai & Wei, Junjie, 2009. "Stability and Hopf bifurcation analysis of a prey–predator system with two delays," Chaos, Solitons & Fractals, Elsevier, vol. 42(5), pages 2606-2613.
    3. Chen, Xiaoxiao & Wang, Xuedi, 2019. "Qualitative analysis and control for predator-prey delays system," Chaos, Solitons & Fractals, Elsevier, vol. 123(C), pages 361-372.
    4. Pang, Liuyong & Zhao, Zhong & Song, Xinyu, 2016. "Cost-effectiveness analysis of optimal strategy for tumor treatment," Chaos, Solitons & Fractals, Elsevier, vol. 87(C), pages 293-301.
    5. Zhou, Haihua & Wang, Zejia & Yuan, Daming & Song, Huijuan, 2021. "Hopf bifurcation of a free boundary problem modeling tumor growth with angiogenesis and two time delays," Chaos, Solitons & Fractals, Elsevier, vol. 153(P1).
    6. Li, Hui-zhong & Liu, Xiang-dong & Yan, Rui & Liu, Cheng, 2020. "Hopf bifurcation analysis of a tumor virotherapy model with two time delays," Physica A: Statistical Mechanics and its Applications, Elsevier, vol. 553(C).
    Full references (including those not matched with items on IDEAS)

    Citations

    Citations are extracted by the CitEc Project, subscribe to its RSS feed for this item.
    as


    Cited by:

    1. Li, Danyang & Liu, Hua & Zhang, Haotian & Wei, Yumei, 2023. "Influence of multiple delays mechanisms on predator–prey model with Allee effect," Chaos, Solitons & Fractals, Elsevier, vol. 175(P1).
    2. Hu, Limi & Qiu, Xiaoling, 2022. "Stability analysis of game models with fixed and stochastic delays," Applied Mathematics and Computation, Elsevier, vol. 435(C).

    Most related items

    These are the items that most often cite the same works as this one and are cited by the same works as this one.
    1. De Cesare, Luigi & Sportelli, Mario, 2022. "A non-linear approach to Kalecki’s investment cycle," Mathematics and Computers in Simulation (MATCOM), Elsevier, vol. 193(C), pages 57-70.
    2. Liu, Xiangdong & Li, Qingze & Pan, Jianxin, 2018. "A deterministic and stochastic model for the system dynamics of tumor–immune responses to chemotherapy," Physica A: Statistical Mechanics and its Applications, Elsevier, vol. 500(C), pages 162-176.
    3. Dubey, Balram & Sajan, & Kumar, Ankit, 2021. "Stability switching and chaos in a multiple delayed prey–predator model with fear effect and anti-predator behavior," Mathematics and Computers in Simulation (MATCOM), Elsevier, vol. 188(C), pages 164-192.
    4. Li, Wenjie & Guan, Yajuan & Cao, Jinde & Xu, Fei, 2024. "Global dynamics and threshold control of a discontinuous fishery ecological system," Chaos, Solitons & Fractals, Elsevier, vol. 182(C).
    5. Ma, Yuanyuan & Dong, Nan & Liu, Na & Xie, Leilei, 2022. "Spatiotemporal and bifurcation characteristics of a nonlinear prey-predator model," Chaos, Solitons & Fractals, Elsevier, vol. 165(P2).
    6. Zhao, Zhong & Pang, Liuyong & Li, Qiuying, 2021. "Analysis of a hybrid impulsive tumor-immune model with immunotherapy and chemotherapy," Chaos, Solitons & Fractals, Elsevier, vol. 144(C).
    7. He, Xue-Zhong & Li, Kai, 2015. "Profitability of time series momentum," Journal of Banking & Finance, Elsevier, vol. 53(C), pages 140-157.
    8. Duan, Wei-Long & Fang, Hui & Zeng, Chunhua, 2019. "The stability analysis of tumor-immune responses to chemotherapy system with gaussian white noises," Chaos, Solitons & Fractals, Elsevier, vol. 127(C), pages 96-102.
    9. Amine, Saida & Hajri, Youssra & Allali, Karam, 2022. "A delayed fractional-order tumor virotherapy model: Stability and Hopf bifurcation," Chaos, Solitons & Fractals, Elsevier, vol. 161(C).
    10. Akio Matsumoto & Ferenc Szidarovszky & Hiroyuki Yoshida, 2011. "Dynamics in Linear Cournot Duopolies with Two Time Delays," Computational Economics, Springer;Society for Computational Economics, vol. 38(3), pages 311-327, October.
    11. Duan, Wei-Long & Lin, Ling, 2021. "Noise and delay enhanced stability in tumor-immune responses to chemotherapy system," Chaos, Solitons & Fractals, Elsevier, vol. 148(C).
    12. Wang, Luxuan & Niu, Ben & Wei, Junjie, 2016. "Dynamical analysis for a model of asset prices with two delays," Physica A: Statistical Mechanics and its Applications, Elsevier, vol. 447(C), pages 297-313.
    13. Qingsong Liu & Yiping Lin & Jingnan Cao & Jinde Cao, 2014. "Chaos and Hopf Bifurcation Analysis of the Delayed Local Lengyel-Epstein System," Discrete Dynamics in Nature and Society, Hindawi, vol. 2014, pages 1-7, March.
    14. Duan, Wei-Long, 2020. "The stability analysis of tumor-immune responses to chemotherapy system driven by Gaussian colored noises," Chaos, Solitons & Fractals, Elsevier, vol. 141(C).
    15. Hommes, Cars & Li, Kai & Wagener, Florian, 2022. "Production delays and price dynamics," Journal of Economic Behavior & Organization, Elsevier, vol. 194(C), pages 341-362.
    16. Gökçe, Aytül & Yazar, Samire & Sekerci, Yadigar, 2022. "Stability of spatial patterns in a diffusive oxygen–plankton model with time lag effect," Mathematics and Computers in Simulation (MATCOM), Elsevier, vol. 194(C), pages 109-123.
    17. Fawaz E. Alsaadi & Amirreza Yasami & Christos Volos & Stelios Bekiros & Hadi Jahanshahi, 2023. "A New Fuzzy Reinforcement Learning Method for Effective Chemotherapy," Mathematics, MDPI, vol. 11(2), pages 1-25, January.
    18. Wang, Qiubao & Hu, Zhouyu & Yang, Yanling & Zhang, Congqing & Han, Zikun, 2023. "The impact of memory effect on time-delay logistic systems driven by a class of non-Gaussian noise," Physica A: Statistical Mechanics and its Applications, Elsevier, vol. 626(C).
    19. Karaoglu, Esra & Merdan, Huseyin, 2014. "Hopf bifurcations of a ratio-dependent predator–prey model involving two discrete maturation time delays," Chaos, Solitons & Fractals, Elsevier, vol. 68(C), pages 159-168.
    20. G. Rigatos & P. Siano & M. Abbaszadeh & T. Ghosh, 2021. "Nonlinear optimal control of coupled time-delayed models of economic growth," Decisions in Economics and Finance, Springer;Associazione per la Matematica, vol. 44(1), pages 375-399, June.

    Corrections

    All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:eee:chsofr:v:157:y:2022:i:c:s0960077922001321. See general information about how to correct material in RePEc.

    If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

    If CitEc recognized a bibliographic reference but did not link an item in RePEc to it, you can help with this form .

    If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.

    For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: Thayer, Thomas R. (email available below). General contact details of provider: https://www.journals.elsevier.com/chaos-solitons-and-fractals .

    Please note that corrections may take a couple of weeks to filter through the various RePEc services.

    IDEAS is a RePEc service. RePEc uses bibliographic data supplied by the respective publishers.