IDEAS home Printed from https://ideas.repec.org/a/eee/chsofr/v132y2020ics096007791930551x.html
   My bibliography  Save this article

A stochastic delay model of HIV pathogenesis with reactivation of latent reservoirs

Author

Listed:
  • Qesmi, Redouane
  • Hammoumi, Aayah

Abstract

In this paper, we propose a stochastic HIV model with latency to describe the factors that are responsible for extinction and persistence of the infection. This model incorporates latent period of reservoirs that inhibits the eradication of the virus. It is shown that this model leads naturally to a stochastic system of differential delay equations. We derived the global existence, positivity and boundedness properties of solutions of the proposed stochastic system. Analyzing the model, sufficient conditions for the eradication and the persistence of the disease are also obtained. Furthermore, numerical simulations are performed to study the impact of several strategies of drug therapy on the persistence and the extinction of HIV virus. Our results constitute an important step towards control strategies to reduce HIV infection.

Suggested Citation

  • Qesmi, Redouane & Hammoumi, Aayah, 2020. "A stochastic delay model of HIV pathogenesis with reactivation of latent reservoirs," Chaos, Solitons & Fractals, Elsevier, vol. 132(C).
    • Handle: RePEc:eee:chsofr:v:132:y:2020:i:c:s096007791930551x
    DOI: 10.1016/j.chaos.2019.109594
    as

    Download full text from publisher

    File URL: http://www.sciencedirect.com/science/article/pii/S096007791930551X
    Download Restriction: Full text for ScienceDirect subscribers only
    File URL: https://libkey.io/10.1016/j.chaos.2019.109594?utm_source=ideas
    LibKey link: if access is restricted and if your library uses this service, LibKey will redirect you to where you can use your library subscription to access this item
    ---><---

    As the access to this document is restricted, you may want to search for a different version of it.

    References listed on IDEAS

    as
    1. Huang, Zaitang & Yang, Qigui & Cao, Junfei, 2011. "Complex dynamics in a stochastic internal HIV model," Chaos, Solitons & Fractals, Elsevier, vol. 44(11), pages 954-963.
    2. Wang, Yan & Jiang, Daqing & Hayat, Tasawar & Ahmad, Bashir, 2017. "A stochastic HIV infection model with T-cell proliferation and CTL immune response," Applied Mathematics and Computation, Elsevier, vol. 315(C), pages 477-493.
    3. Yan Wang & Daqing Jiang, 2017. "Stationary Distribution and Extinction of a Stochastic Viral Infection Model," Discrete Dynamics in Nature and Society, Hindawi, vol. 2017, pages 1-13, October.
    4. Mao, Xuerong & Marion, Glenn & Renshaw, Eric, 2002. "Environmental Brownian noise suppresses explosions in population dynamics," Stochastic Processes and their Applications, Elsevier, vol. 97(1), pages 95-110, January.
    5. Jiang, Daqing & Liu, Qun & Shi, Ningzhong & Hayat, Tasawar & Alsaedi, Ahmed & Xia, Peiyan, 2017. "Dynamics of a stochastic HIV-1 infection model with logistic growth," Physica A: Statistical Mechanics and its Applications, Elsevier, vol. 469(C), pages 706-717.
    Full references (including those not matched with items on IDEAS)

    Citations

    Citations are extracted by the CitEc Project, subscribe to its RSS feed for this item.
    as


    Cited by:

    1. Liu, Qun & Jiang, Daqing, 2020. "Dynamical behavior of a higher order stochastically perturbed HIV/AIDS model with differential infectivity and amelioration," Chaos, Solitons & Fractals, Elsevier, vol. 141(C).

    Most related items

    These are the items that most often cite the same works as this one and are cited by the same works as this one.
    1. Wang, Yan & Jiang, Daqing & Alsaedi, Ahmed & Hayat, Tasawar, 2018. "Modelling a stochastic HIV model with logistic target cell growth and nonlinear immune response function," Physica A: Statistical Mechanics and its Applications, Elsevier, vol. 501(C), pages 276-292.
    2. Cheng, Yan & Li, Mingtao & Zhang, Fumin, 2019. "A dynamics stochastic model with HIV infection of CD4+ T-cells driven by Lévy noise," Chaos, Solitons & Fractals, Elsevier, vol. 129(C), pages 62-70.
    3. Chinnadurai, M. & Fatini, Mohamed El & Rathinasamy, A., 2023. "Stochastic perturbation to 2-LTR dynamical model in HIV infected patients," Mathematics and Computers in Simulation (MATCOM), Elsevier, vol. 204(C), pages 473-497.
    4. Wang, Yan & Qi, Kai & Jiang, Daqing, 2021. "An HIV latent infection model with cell-to-cell transmission and stochastic perturbation," Chaos, Solitons & Fractals, Elsevier, vol. 151(C).
    5. Wang, Yan & Jiang, Daqing & Hayat, Tasawar & Ahmad, Bashir, 2017. "A stochastic HIV infection model with T-cell proliferation and CTL immune response," Applied Mathematics and Computation, Elsevier, vol. 315(C), pages 477-493.
    6. Qi, Kai & Jiang, Daqing & Hayat, Tasawar & Alsaedi, Ahmed, 2021. "Virus dynamic behavior of a stochastic HIV/AIDS infection model including two kinds of target cell infections and CTL immune responses," Mathematics and Computers in Simulation (MATCOM), Elsevier, vol. 188(C), pages 548-570.
    7. Rajasekar, S.P. & Pitchaimani, M. & Zhu, Quanxin, 2020. "Progressive dynamics of a stochastic epidemic model with logistic growth and saturated treatment," Physica A: Statistical Mechanics and its Applications, Elsevier, vol. 538(C).
    8. Zhang, Tongqian & Xu, Xinna & Wang, Xinzeng, 2023. "Dynamic analysis of a cytokine-enhanced viral infection model with time delays and CTL immune response," Chaos, Solitons & Fractals, Elsevier, vol. 170(C).
    9. Tan, Yiping & Cai, Yongli & Sun, Xiaodan & Wang, Kai & Yao, Ruoxia & Wang, Weiming & Peng, Zhihang, 2022. "A stochastic SICA model for HIV/AIDS transmission," Chaos, Solitons & Fractals, Elsevier, vol. 165(P1).
    10. Lu, Minmin & Wang, Yan & Jiang, Daqing, 2021. "Stationary distribution and probability density function analysis of a stochastic HIV model with cell-to-cell infection," Applied Mathematics and Computation, Elsevier, vol. 410(C).
    11. Shi, Zhenfeng & Jiang, Daqing, 2022. "Dynamical behaviors of a stochastic HTLV-I infection model with general infection form and Ornstein–Uhlenbeck process," Chaos, Solitons & Fractals, Elsevier, vol. 165(P2).
    12. Lin Hu & Lin-Fei Nie, 2022. "Dynamics of a Stochastic HIV Infection Model with Logistic Growth and CTLs Immune Response under Regime Switching," Mathematics, MDPI, vol. 10(19), pages 1-20, September.
    13. Prakash, M. & Rakkiyappan, R. & Manivannan, A. & Cao, Jinde, 2019. "Dynamical analysis of antigen-driven T-cell infection model with multiple delays," Applied Mathematics and Computation, Elsevier, vol. 354(C), pages 266-281.
    14. Li, Qiuyue & Cong, Fuzhong & Liu, Tianbao & Zhou, Yaoming, 2020. "Stationary distribution of a stochastic HIV model with two infective stages," Physica A: Statistical Mechanics and its Applications, Elsevier, vol. 554(C).
    15. Zhou, Baoquan & Han, Bingtao & Jiang, Daqing, 2021. "Ergodic property, extinction and density function of a stochastic SIR epidemic model with nonlinear incidence and general stochastic perturbations," Chaos, Solitons & Fractals, Elsevier, vol. 152(C).
    16. Arshad, Sadia & Defterli, Ozlem & Baleanu, Dumitru, 2020. "A second order accurate approximation for fractional derivatives with singular and non-singular kernel applied to a HIV model," Applied Mathematics and Computation, Elsevier, vol. 374(C).
    17. Tong, Jinying & Zhang, Zhenzhong & Bao, Jianhai, 2013. "The stationary distribution of the facultative population model with a degenerate noise," Statistics & Probability Letters, Elsevier, vol. 83(2), pages 655-664.
    18. Huang, Zaitang & Cao, Junfei, 2018. "Ergodicity and bifurcations for stochastic logistic equation with non-Gaussian Lévy noise," Applied Mathematics and Computation, Elsevier, vol. 330(C), pages 1-10.
    19. Shi, Zhenfeng & Zhang, Xinhong & Jiang, Daqing, 2019. "Dynamics of an avian influenza model with half-saturated incidence," Applied Mathematics and Computation, Elsevier, vol. 355(C), pages 399-416.
    20. Liu, Meng & Wang, Ke, 2009. "Survival analysis of stochastic single-species population models in polluted environments," Ecological Modelling, Elsevier, vol. 220(9), pages 1347-1357.

    Corrections

    All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:eee:chsofr:v:132:y:2020:i:c:s096007791930551x. See general information about how to correct material in RePEc.

    If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

    If CitEc recognized a bibliographic reference but did not link an item in RePEc to it, you can help with this form .

    If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.

    For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: Thayer, Thomas R. (email available below). General contact details of provider: https://www.journals.elsevier.com/chaos-solitons-and-fractals .

    Please note that corrections may take a couple of weeks to filter through the various RePEc services.

    IDEAS is a RePEc service. RePEc uses bibliographic data supplied by the respective publishers.