IDEAS home Printed from https://ideas.repec.org/a/bpj/causin/v4y2016i1p31-48n2.html
   My bibliography  Save this article

Markov Boundary Discovery with Ridge Regularized Linear Models

Author

Listed:
  • Strobl Eric V.

    (Center for Causal Discovery, Department of Biomedical Informatics, University of Pittsburgh School of Medicine, 5607 Baum Boulevard, Pittsburgh, PA 15206, USA)

  • Visweswaran Shyam

    (Center for Causal Discovery, Department of Biomedical Informatics, University of Pittsburgh School of Medicine, 5607 Baum Boulevard, Pittsburgh, PA 15206, USA)

Abstract

Ridge regularized linear models (RRLMs), such as ridge regression and the SVM, are a popular group of methods that are used in conjunction with coefficient hypothesis testing to discover explanatory variables with a significant multivariate association to a response. However, many investigators are reluctant to draw causal interpretations of the selected variables due to the incomplete knowledge of the capabilities of RRLMs in causal inference. Under reasonable assumptions, we show that a modified form of RRLMs can get “very close” to identifying a subset of the Markov boundary by providing a worst-case bound on the space of possible solutions. The results hold for any convex loss, even when the underlying functional relationship is nonlinear, and the solution is not unique. Our approach combines ideas in Markov boundary and sufficient dimension reduction theory. Experimental results show that the modified RRLMs are competitive against state-of-the-art algorithms in discovering part of the Markov boundary from gene expression data.

Suggested Citation

  • Strobl Eric V. & Visweswaran Shyam, 2016. "Markov Boundary Discovery with Ridge Regularized Linear Models," Journal of Causal Inference, De Gruyter, vol. 4(1), pages 31-48, March.
    • Handle: RePEc:bpj:causin:v:4:y:2016:i:1:p:31-48:n:2
    DOI: 10.1515/jci-2015-0011
    as

    Download full text from publisher

    File URL: https://doi.org/10.1515/jci-2015-0011
    Download Restriction: no
    File URL: https://libkey.io/10.1515/jci-2015-0011?utm_source=ideas
    LibKey link: if access is restricted and if your library uses this service, LibKey will redirect you to where you can use your library subscription to access this item
    ---><---

    References listed on IDEAS

    as
    1. Kenji Fukumizu & Chenlei Leng, 2014. "Gradient-Based Kernel Dimension Reduction for Regression," Journal of the American Statistical Association, Taylor & Francis Journals, vol. 109(505), pages 359-370, March.
    2. Eaton, Morris L., 1986. "A characterization of spherical distributions," Journal of Multivariate Analysis, Elsevier, vol. 20(2), pages 272-276, December.
    Full references (including those not matched with items on IDEAS)

    Most related items

    These are the items that most often cite the same works as this one and are cited by the same works as this one.
    1. Heng-Hui Lue, 2015. "An Inverse-regression Method of Dependent Variable Transformation for Dimension Reduction with Non-linear Confounding," Scandinavian Journal of Statistics, Danish Society for Theoretical Statistics;Finnish Statistical Society;Norwegian Statistical Association;Swedish Statistical Association, vol. 42(3), pages 760-774, September.
    2. Alessandro Barbarino & Efstathia Bura, 2015. "Forecasting with Sufficient Dimension Reductions," Finance and Economics Discussion Series 2015-74, Board of Governors of the Federal Reserve System (U.S.).
    3. Maruyama Yuzo, 2003. "A robust generalized Bayes estimator improving on the James-Stein estimator for spherically symmetric distributions," Statistics & Risk Modeling, De Gruyter, vol. 21(1), pages 69-78, January.
    4. Kai-Tai Fang & Run-Ze Li, 1997. "Some methods for generating both an NT-net and the uniform distribution on a Stiefel manifold and their applications," Computational Statistics & Data Analysis, Elsevier, vol. 24(1), pages 29-46, March.
    5. Cizek, Pavel & Sadikoglu, Serhan, 2022. "Nonseparable Panel Models with Index Structure and Correlated Random Effects," Other publications TiSEM 7899deb9-0eda-47e6-a3b8-2, Tilburg University, School of Economics and Management.
    6. Wang, Qin & Xue, Yuan, 2021. "An ensemble of inverse moment estimators for sufficient dimension reduction," Computational Statistics & Data Analysis, Elsevier, vol. 161(C).
    7. Mehni, Moien Barkhori & Mehni, Mohammad Barkhori, 2023. "Reliability analysis with cross-entropy based adaptive Markov chain importance sampling and control variates," Reliability Engineering and System Safety, Elsevier, vol. 231(C).
    8. Kariya, Takeaki & Kurata, Hiroshi, 2002. "A Maximal Extension of the Gauss-Markov Theorem and Its Nonlinear Version," Journal of Multivariate Analysis, Elsevier, vol. 83(1), pages 37-55, October.
    9. Dong, Yuexiao & Yu, Zhou, 2012. "Dimension reduction for the conditional kth moment via central solution space," Journal of Multivariate Analysis, Elsevier, vol. 112(C), pages 207-218.
    10. He, Xin & Mao, Xiaojun & Wang, Zhonglei, 2024. "Nonparametric augmented probability weighting with sparsity," Computational Statistics & Data Analysis, Elsevier, vol. 191(C).
    11. Papadatos, Nickos, 2014. "Some counterexamples concerning maximal correlation and linear regression," Journal of Multivariate Analysis, Elsevier, vol. 126(C), pages 114-117.
    12. Ian Ball, 2019. "Scoring Strategic Agents," Papers 1909.01888, arXiv.org, revised May 2024.
    13. Wenbin Lu & Lexin Li, 2011. "Sufficient Dimension Reduction for Censored Regressions," Biometrics, The International Biometric Society, vol. 67(2), pages 513-523, June.
    14. Portier, François & Delyon, Bernard, 2013. "Optimal transformation: A new approach for covering the central subspace," Journal of Multivariate Analysis, Elsevier, vol. 115(C), pages 84-107.
    15. Gannoun, Ali & Girard, Stephane & Guinot, Christiane & Saracco, Jerome, 2004. "Sliced inverse regression in reference curves estimation," Computational Statistics & Data Analysis, Elsevier, vol. 46(1), pages 103-122, May.
    16. Sadikoglu, Serhan, 2019. "Essays in econometric theory," Other publications TiSEM 99d83644-f9dc-49e3-a4e1-5, Tilburg University, School of Economics and Management.
    17. Alessandro Barbarino & Efstathia Bura, 2017. "A Unified Framework for Dimension Reduction in Forecasting," Finance and Economics Discussion Series 2017-004, Board of Governors of the Federal Reserve System (U.S.).
    18. Li, Lexin & Dennis Cook, R. & Nachtsheim, Christopher J., 2004. "Cluster-based estimation for sufficient dimension reduction," Computational Statistics & Data Analysis, Elsevier, vol. 47(1), pages 175-193, August.
    19. Liu, Xuejing & Yu, Zhou & Wen, Xuerong Meggie & Paige, Robert, 2015. "On testing common indices for two multi-index models: A link-free approach," Journal of Multivariate Analysis, Elsevier, vol. 136(C), pages 75-85.
    20. Lexin Li & Xiangrong Yin, 2008. "Sliced Inverse Regression with Regularizations," Biometrics, The International Biometric Society, vol. 64(1), pages 124-131, March.

    Corrections

    All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:bpj:causin:v:4:y:2016:i:1:p:31-48:n:2. See general information about how to correct material in RePEc.

    If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

    If CitEc recognized a bibliographic reference but did not link an item in RePEc to it, you can help with this form .

    If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.

    For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: Peter Golla (email available below). General contact details of provider: https://www.degruyter.com .

    Please note that corrections may take a couple of weeks to filter through the various RePEc services.

    IDEAS is a RePEc service. RePEc uses bibliographic data supplied by the respective publishers.