IDEAS home Printed from https://ideas.repec.org/a/bla/biomet/v78y2022i2p716-729.html
   My bibliography  Save this article

Pursuing sources of heterogeneity in modeling clustered population

Author

Listed:
  • Yan Li
  • Chun Yu
  • Yize Zhao
  • Weixin Yao
  • Robert H. Aseltine
  • Kun Chen

Abstract

Researchers often have to deal with heterogeneous population with mixed regression relationships, increasingly so in the era of data explosion. In such problems, when there are many candidate predictors, it is not only of interest to identify the predictors that are associated with the outcome, but also to distinguish the true sources of heterogeneity, that is, to identify the predictors that have different effects among the clusters and thus are the true contributors to the formation of the clusters. We clarify the concepts of the source of heterogeneity that account for potential scale differences of the clusters and propose a regularized finite mixture effects regression to achieve heterogeneity pursuit and feature selection simultaneously. We develop an efficient algorithm and show that our approach can achieve both estimation and selection consistency. Simulation studies further demonstrate the effectiveness of our method under various practical scenarios. Three applications are presented, namely, an imaging genetics study for linking genetic factors and brain neuroimaging traits in Alzheimer's disease, a public health study for exploring the association between suicide risk among adolescents and their school district characteristics, and a sport analytics study for understanding how the salary levels of baseball players are associated with their performance and contractual status.

Suggested Citation

  • Yan Li & Chun Yu & Yize Zhao & Weixin Yao & Robert H. Aseltine & Kun Chen, 2022. "Pursuing sources of heterogeneity in modeling clustered population," Biometrics, The International Biometric Society, vol. 78(2), pages 716-729, June.
  • Handle: RePEc:bla:biomet:v:78:y:2022:i:2:p:716-729
    DOI: 10.1111/biom.13434
    as

    Download full text from publisher

    File URL: https://doi.org/10.1111/biom.13434
    Download Restriction: no

    File URL: https://libkey.io/10.1111/biom.13434?utm_source=ideas
    LibKey link: if access is restricted and if your library uses this service, LibKey will redirect you to where you can use your library subscription to access this item
    ---><---

    References listed on IDEAS

    as
    1. Zou, Hui, 2006. "The Adaptive Lasso and Its Oracle Properties," Journal of the American Statistical Association, American Statistical Association, vol. 101, pages 1418-1429, December.
    2. Benhuai Xie & Wei Pan & Xiaotong Shen, 2008. "Variable Selection in Penalized Model‐Based Clustering Via Regularization on Grouped Parameters," Biometrics, The International Biometric Society, vol. 64(3), pages 921-930, September.
    3. Michel Wedel & Wayne DeSarbo, 1995. "A mixture likelihood approach for generalized linear models," Journal of Classification, Springer;The Classification Society, vol. 12(1), pages 21-55, March.
    4. Goldfeld, Stephen M. & Quandt, Richard E., 1973. "A Markov model for switching regressions," Journal of Econometrics, Elsevier, vol. 1(1), pages 3-15, March.
    5. Kun Chen & Neha Mishra & Joan Smyth & Haim Bar & Elizabeth Schifano & Lynn Kuo & Ming-Hui Chen, 2018. "A Tailored Multivariate Mixture Model for Detecting Proteins of Concordant Change Among Virulent Strains of Clostridium Perfringens," Journal of the American Statistical Association, Taylor & Francis Journals, vol. 113(522), pages 546-559, April.
    6. Fatma Zehra Doğru & Olcay Arslan, 2017. "Parameter estimation for mixtures of skew Laplace normal distributions and application in mixture regression modeling," Communications in Statistics - Theory and Methods, Taylor & Francis Journals, vol. 46(21), pages 10879-10896, November.
    7. Hui Zou & Trevor Hastie, 2005. "Addendum: Regularization and variable selection via the elastic net," Journal of the Royal Statistical Society Series B, Royal Statistical Society, vol. 67(5), pages 768-768, November.
    8. Hui Zou & Trevor Hastie, 2005. "Regularization and variable selection via the elastic net," Journal of the Royal Statistical Society Series B, Royal Statistical Society, vol. 67(2), pages 301-320, April.
    9. Khalili, Abbas & Chen, Jiahua, 2007. "Variable Selection in Finite Mixture of Regression Models," Journal of the American Statistical Association, American Statistical Association, vol. 102, pages 1025-1038, September.
    10. Fan J. & Li R., 2001. "Variable Selection via Nonconcave Penalized Likelihood and its Oracle Properties," Journal of the American Statistical Association, American Statistical Association, vol. 96, pages 1348-1360, December.
    11. Shujie Ma & Jian Huang, 2017. "A Concave Pairwise Fusion Approach to Subgroup Analysis," Journal of the American Statistical Association, Taylor & Francis Journals, vol. 112(517), pages 410-423, January.
    12. Abbas Khalili & Shili Lin, 2013. "Regularization in Finite Mixture of Regression Models with Diverging Number of Parameters," Biometrics, The International Biometric Society, vol. 69(2), pages 436-446, June.
    Full references (including those not matched with items on IDEAS)

    Citations

    Citations are extracted by the CitEc Project, subscribe to its RSS feed for this item.
    as


    Cited by:

    1. Shao, Lihui & Wu, Jiaqi & Zhang, Weiping & Chen, Yu, 2024. "Integrated subgroup identification from multi-source data," Computational Statistics & Data Analysis, Elsevier, vol. 193(C).

    Most related items

    These are the items that most often cite the same works as this one and are cited by the same works as this one.
    1. Qingguo Tang & R. J. Karunamuni, 2018. "Robust variable selection for finite mixture regression models," Annals of the Institute of Statistical Mathematics, Springer;The Institute of Statistical Mathematics, vol. 70(3), pages 489-521, June.
    2. Lee, Kuo-Jung & Feldkircher, Martin & Chen, Yi-Chi, 2021. "Variable selection in finite mixture of regression models with an unknown number of components," Computational Statistics & Data Analysis, Elsevier, vol. 158(C).
    3. Huicong Yu & Jiaqi Wu & Weiping Zhang, 2024. "Simultaneous subgroup identification and variable selection for high dimensional data," Computational Statistics, Springer, vol. 39(6), pages 3181-3205, September.
    4. Ping Zeng & Yongyue Wei & Yang Zhao & Jin Liu & Liya Liu & Ruyang Zhang & Jianwei Gou & Shuiping Huang & Feng Chen, 2014. "Variable selection approach for zero-inflated count data via adaptive lasso," Journal of Applied Statistics, Taylor & Francis Journals, vol. 41(4), pages 879-894, April.
    5. Shuichi Kawano, 2021. "Sparse principal component regression via singular value decomposition approach," Advances in Data Analysis and Classification, Springer;German Classification Society - Gesellschaft für Klassifikation (GfKl);Japanese Classification Society (JCS);Classification and Data Analysis Group of the Italian Statistical Society (CLADAG);International Federation of Classification Societies (IFCS), vol. 15(3), pages 795-823, September.
    6. Tutz, Gerhard & Pößnecker, Wolfgang & Uhlmann, Lorenz, 2015. "Variable selection in general multinomial logit models," Computational Statistics & Data Analysis, Elsevier, vol. 82(C), pages 207-222.
    7. Margherita Giuzio, 2017. "Genetic algorithm versus classical methods in sparse index tracking," Decisions in Economics and Finance, Springer;Associazione per la Matematica, vol. 40(1), pages 243-256, November.
    8. Yize Zhao & Matthias Chung & Brent A. Johnson & Carlos S. Moreno & Qi Long, 2016. "Hierarchical Feature Selection Incorporating Known and Novel Biological Information: Identifying Genomic Features Related to Prostate Cancer Recurrence," Journal of the American Statistical Association, Taylor & Francis Journals, vol. 111(516), pages 1427-1439, October.
    9. Gareth M. James & Peter Radchenko & Jinchi Lv, 2009. "DASSO: connections between the Dantzig selector and lasso," Journal of the Royal Statistical Society Series B, Royal Statistical Society, vol. 71(1), pages 127-142, January.
    10. Umberto Amato & Anestis Antoniadis & Italia De Feis & Irene Gijbels, 2021. "Penalised robust estimators for sparse and high-dimensional linear models," Statistical Methods & Applications, Springer;Società Italiana di Statistica, vol. 30(1), pages 1-48, March.
    11. Camila Epprecht & Dominique Guegan & Álvaro Veiga & Joel Correa da Rosa, 2017. "Variable selection and forecasting via automated methods for linear models: LASSO/adaLASSO and Autometrics," Post-Print halshs-00917797, HAL.
    12. Wang, Christina Dan & Chen, Zhao & Lian, Yimin & Chen, Min, 2022. "Asset selection based on high frequency Sharpe ratio," Journal of Econometrics, Elsevier, vol. 227(1), pages 168-188.
    13. Bartosz Uniejewski, 2024. "Regularization for electricity price forecasting," Papers 2404.03968, arXiv.org.
    14. Peter Bühlmann & Jacopo Mandozzi, 2014. "High-dimensional variable screening and bias in subsequent inference, with an empirical comparison," Computational Statistics, Springer, vol. 29(3), pages 407-430, June.
    15. Peter Martey Addo & Dominique Guegan & Bertrand Hassani, 2018. "Credit Risk Analysis Using Machine and Deep Learning Models," Risks, MDPI, vol. 6(2), pages 1-20, April.
    16. Capanu, Marinela & Giurcanu, Mihai & Begg, Colin B. & Gönen, Mithat, 2023. "Subsampling based variable selection for generalized linear models," Computational Statistics & Data Analysis, Elsevier, vol. 184(C).
    17. Weng, Jiaying, 2022. "Fourier transform sparse inverse regression estimators for sufficient variable selection," Computational Statistics & Data Analysis, Elsevier, vol. 168(C).
    18. Ander Wilson & Brian J. Reich, 2014. "Confounder selection via penalized credible regions," Biometrics, The International Biometric Society, vol. 70(4), pages 852-861, December.
    19. Loann David Denis Desboulets, 2018. "A Review on Variable Selection in Regression Analysis," Econometrics, MDPI, vol. 6(4), pages 1-27, November.
    20. Zeyu Bian & Erica E. M. Moodie & Susan M. Shortreed & Sahir Bhatnagar, 2023. "Variable selection in regression‐based estimation of dynamic treatment regimes," Biometrics, The International Biometric Society, vol. 79(2), pages 988-999, June.

    More about this item

    Statistics

    Access and download statistics

    Corrections

    All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:bla:biomet:v:78:y:2022:i:2:p:716-729. See general information about how to correct material in RePEc.

    If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

    If CitEc recognized a bibliographic reference but did not link an item in RePEc to it, you can help with this form .

    If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.

    For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: Wiley Content Delivery (email available below). General contact details of provider: http://www.blackwellpublishing.com/journal.asp?ref=0006-341X .

    Please note that corrections may take a couple of weeks to filter through the various RePEc services.

    IDEAS is a RePEc service. RePEc uses bibliographic data supplied by the respective publishers.