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Semiparametric regression analysis of length‐biased interval‐censored data

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  • Fei Gao
  • Kwun Chuen Gary Chan

Abstract

In prevalent cohort design, subjects who have experienced an initial event but not the failure event are preferentially enrolled and the observed failure times are often length‐biased. Moreover, the prospective follow‐up may not be continuously monitored and failure times are subject to interval censoring. We study the nonparametric maximum likelihood estimation for the proportional hazards model with length‐biased interval‐censored data. Direct maximization of likelihood function is intractable, thus we develop a computationally simple and stable expectation‐maximization algorithm through introducing two layers of data augmentation. We establish the strong consistency, asymptotic normality and efficiency of the proposed estimator and provide an inferential procedure through profile likelihood. We assess the performance of the proposed methods through extensive simulations and apply the proposed methods to the Massachusetts Health Care Panel Study.

Suggested Citation

  • Fei Gao & Kwun Chuen Gary Chan, 2019. "Semiparametric regression analysis of length‐biased interval‐censored data," Biometrics, The International Biometric Society, vol. 75(1), pages 121-132, March.
    • Handle: RePEc:bla:biomet:v:75:y:2019:i:1:p:121-132
    DOI: 10.1111/biom.12970
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    References listed on IDEAS

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    Cited by:

    1. Tianyi Lu & Shuwei Li & Liuquan Sun, 2023. "Combined estimating equation approaches for the additive hazards model with left-truncated and interval-censored data," Lifetime Data Analysis: An International Journal Devoted to Statistical Methods and Applications for Time-to-Event Data, Springer, vol. 29(3), pages 672-697, July.
    2. Li‐Pang Chen & Bangxu Qiu, 2023. "Analysis of length‐biased and partly interval‐censored survival data with mismeasured covariates," Biometrics, The International Biometric Society, vol. 79(4), pages 3929-3940, December.
    3. Fan Feng & Guanghui Cheng & Jianguo Sun, 2023. "Variable Selection for Length-Biased and Interval-Censored Failure Time Data," Mathematics, MDPI, vol. 11(22), pages 1-20, November.
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    5. Tao Sun & Ying Ding, 2023. "Neural network on interval‐censored data with application to the prediction of Alzheimer's disease," Biometrics, The International Biometric Society, vol. 79(3), pages 2677-2690, September.

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