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Propensity score matching and subclassification in observational studies with multi‐level treatments

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  • Shu Yang
  • Guido W. Imbens
  • Zhanglin Cui
  • Douglas E. Faries
  • Zbigniew Kadziola

Abstract

In this article, we develop new methods for estimating average treatment effects in observational studies, in settings with more than two treatment levels, assuming unconfoundedness given pretreatment variables. We emphasize propensity score subclassification and matching methods which have been among the most popular methods in the binary treatment literature. Whereas the literature has suggested that these particular propensity‐based methods do not naturally extend to the multi‐level treatment case, we show, using the concept of weak unconfoundedness and the notion of the generalized propensity score, that adjusting for a scalar function of the pretreatment variables removes all biases associated with observed pretreatment variables. We apply the proposed methods to an analysis of the effect of treatments for fibromyalgia. We also carry out a simulation study to assess the finite sample performance of the methods relative to previously proposed methods.

Suggested Citation

  • Shu Yang & Guido W. Imbens & Zhanglin Cui & Douglas E. Faries & Zbigniew Kadziola, 2016. "Propensity score matching and subclassification in observational studies with multi‐level treatments," Biometrics, The International Biometric Society, vol. 72(4), pages 1055-1065, December.
  • Handle: RePEc:bla:biomet:v:72:y:2016:i:4:p:1055-1065
    DOI: 10.1111/biom.12505
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    1. Richard K. Crump & V. Joseph Hotz & Guido W. Imbens & Oscar A. Mitnik, 2009. "Dealing with limited overlap in estimation of average treatment effects," Biometrika, Biometrika Trust, vol. 96(1), pages 187-199.
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    5. Hajime Seya & Takahiro Yoshida, 2017. "Propensity score matching for multiple treatment levels: A CODA-based contribution," Papers 1710.08558, arXiv.org.
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    8. Lee, Ying-Ying, 2018. "Efficient propensity score regression estimators of multivalued treatment effects for the treated," Journal of Econometrics, Elsevier, vol. 204(2), pages 207-222.
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    13. Rachel C. Nethery & Yue Yang & Anna J. Brown & Francesca Dominici, 2020. "A causal inference framework for cancer cluster investigations using publicly available data," Journal of the Royal Statistical Society Series A, Royal Statistical Society, vol. 183(3), pages 1253-1272, June.
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    15. Ganesh Karapakula, 2023. "Stable Probability Weighting: Large-Sample and Finite-Sample Estimation and Inference Methods for Heterogeneous Causal Effects of Multivalued Treatments Under Limited Overlap," Papers 2301.05703, arXiv.org, revised Jan 2023.
    16. Ao Yuan & Anqi Yin & Ming T. Tan, 2021. "Enhanced Doubly Robust Procedure for Causal Inference," Statistics in Biosciences, Springer;International Chinese Statistical Association, vol. 13(3), pages 454-478, December.
    17. Zhang, Xiaoke & Xue, Wu & Wang, Qiyue, 2021. "Covariate balancing functional propensity score for functional treatments in cross-sectional observational studies," Computational Statistics & Data Analysis, Elsevier, vol. 163(C).
    18. Zetterqvist, Johan & Waernbaum, Ingeborg, 2020. "Semi-parametric estimation of multi-valued treatment effects for the treated:estimating equations and sandwich estimators," Working Paper Series 2020:4, IFAU - Institute for Evaluation of Labour Market and Education Policy.
    19. Pedro H. C. Sant'Anna & Xiaojun Song, 2020. "Specification tests for generalized propensity scores using double projections," Papers 2003.13803, arXiv.org, revised Apr 2023.
    20. María de los Angeles Resa & José R. Zubizarreta, 2020. "Direct and stable weight adjustment in non‐experimental studies with multivalued treatments: analysis of the effect of an earthquake on post‐traumatic stress," Journal of the Royal Statistical Society Series A, Royal Statistical Society, vol. 183(4), pages 1387-1410, October.
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    22. Cei, Leonardo & Stefani, Gianluca & Defrancesco, Edi, 2020. "The role of group-time treatment effect heterogeneity in long standing European agricultural policies. An application to the European geographical indication policy," Bio-based and Applied Economics Journal, Italian Association of Agricultural and Applied Economics (AIEAA), vol. 9(1), April.

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