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Linear Score Tests for Variance Components in Linear Mixed Models and Applications to Genetic Association Studies

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  • Long Qu
  • Tobias Guennel
  • Scott L. Marshall

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  • Long Qu & Tobias Guennel & Scott L. Marshall, 2013. "Linear Score Tests for Variance Components in Linear Mixed Models and Applications to Genetic Association Studies," Biometrics, The International Biometric Society, vol. 69(4), pages 883-892, December.
    • Handle: RePEc:bla:biomet:v:69:y:2013:i:4:p:883-892
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    References listed on IDEAS

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    1. Maxwell King & Ping Wu, 1997. "Locally optimal one-sided tests for multiparameter hypotheses," Econometric Reviews, Taylor & Francis Journals, vol. 16(2), pages 131-156.
    2. Jelle J. Goeman & Sara A. Van De Geer & Hans C. Van Houwelingen, 2006. "Testing against a high dimensional alternative," Journal of the Royal Statistical Society Series B, Royal Statistical Society, vol. 68(3), pages 477-493, June.
    3. David Ruppert & Dan Nettleton & J. T. Gene Hwang, 2007. "Exploring the Information in p-Values for the Analysis and Planning of Multiple-Test Experiments," Biometrics, The International Biometric Society, vol. 63(2), pages 483-495, June.
    4. Crainiceanu, Ciprian M. & Ruppert, David, 2004. "Likelihood ratio tests for goodness-of-fit of a nonlinear regression model," Journal of Multivariate Analysis, Elsevier, vol. 91(1), pages 35-52, October.
    5. Jelle J. Goeman & Hans C. van Houwelingen & Livio Finos, 2011. "Testing against a high-dimensional alternative in the generalized linear model: asymptotic type I error control," Biometrika, Biometrika Trust, vol. 98(2), pages 381-390.
    6. repec:adr:anecst:y:1986:i:4:p:05 is not listed on IDEAS
    7. Jan R. Magnus, 1986. "The Exact Moments of a Ratio of Quadratic Forms in Normal Variables," Annals of Economics and Statistics, GENES, issue 4, pages 95-109.
    8. Dawei Liu & Xihong Lin & Debashis Ghosh, 2007. "Semiparametric Regression of Multidimensional Genetic Pathway Data: Least-Squares Kernel Machines and Linear Mixed Models," Biometrics, The International Biometric Society, vol. 63(4), pages 1079-1088, December.
    9. Allison, David B. & Gadbury, Gary L. & Heo, Moonseong & Fernandez, Jose R. & Lee, Cheol-Koo & Prolla, Tomas A. & Weindruch, Richard, 2002. "A mixture model approach for the analysis of microarray gene expression data," Computational Statistics & Data Analysis, Elsevier, vol. 39(1), pages 1-20, March.
    10. Ciprian M. Crainiceanu & David Ruppert, 2004. "Likelihood ratio tests in linear mixed models with one variance component," Journal of the Royal Statistical Society Series B, Royal Statistical Society, vol. 66(1), pages 165-185, February.
    11. Geert Verbeke & Geert Molenberghs, 2003. "The Use of Score Tests for Inference on Variance Components," Biometrics, The International Biometric Society, vol. 59(2), pages 254-262, June.
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    Cited by:

    1. Baey, Charlotte & Cournède, Paul-Henry & Kuhn, Estelle, 2019. "Asymptotic distribution of likelihood ratio test statistics for variance components in nonlinear mixed effects models," Computational Statistics & Data Analysis, Elsevier, vol. 135(C), pages 107-122.

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