IDEAS home Printed from https://ideas.repec.org/a/adm/journl/v9y2020i9p1-15.html
   My bibliography  Save this article

Evaluation of Aster bakerianus Burtt Davy ex C.A. Sm. Crude Root Extract for Acute Antiinflammatory Activity in Rats

Author

Listed:
  • Sibusisiwe Magama
  • Asita Okorie Asita
  • Teboho Derrick Skundla

Abstract

The crude extract of Aster bakerianus roots used for treatment of a variety of ailments in Lesotho was evaluated for anti-inflammatory activity and phytochemical content. Extract was first tested for toxicity at oral dosages of 0 (negative control), 1000, 2000, 3000 and 5000 mg/kg bw with five groups of female mice, each group having four mice. Negative control group received sterile distilled water (1.0 ml/kg bw). Mice were observed for general symptoms of toxicity for 24 hours and left for a further 14 days for any delayed toxicity. None of the extract doses induced toxicity. Anti-inflammatory activity of A. bakerianus was determined using the carrageenan-induced rat paw oedema assay. Five groups of six mice each were orally pre-treated as follows: Negative control group (group 1) received sterile distilled water (1.0 ml/kg bw). Positive control group (group 2) received indomethacin (10mg/kg bw). Three test groups (group 3, 4 and 5) received A. bakerianus extract, 100, 200 and 400 mg/kg bw respectively. After one hour of pre-treatment, all test groups and controls were injected with 0.1 ml carrageenan subcutaneously in the right hind paw and paw thicknesses recorded at the following time intervals: 0, 1, 2, 3, 4, 5, 6, and 24 hours. Statistically (p

Suggested Citation

  • Sibusisiwe Magama & Asita Okorie Asita & Teboho Derrick Skundla, 2020. "Evaluation of Aster bakerianus Burtt Davy ex C.A. Sm. Crude Root Extract for Acute Antiinflammatory Activity in Rats," International Journal of Sciences, Office ijSciences, vol. 9(09), pages 1-15, September.
    • Handle: RePEc:adm:journl:v:9:y:2020:i:9:p:1-15
    DOI: 10.18483/ijSci.2377
    as

    Download full text from publisher

    File URL: https://www.ijsciences.com/pub/article/2377
    Download Restriction: no
    File URL: https://www.ijsciences.com/pub/pdf/V92020092377.pdf
    Download Restriction: no
    File URL: https://libkey.io/10.18483/ijSci.2377?utm_source=ideas
    LibKey link: if access is restricted and if your library uses this service, LibKey will redirect you to where you can use your library subscription to access this item
    ---><---

    References listed on IDEAS

    as
    1. Sibusisiwe Magama & Asita Okorie Asita, 2017. "Evaluation of Chenopodium album Linn. Crude Methanolic Leaf Extract for Central Antinociceptive Activity in Albino Mice using the Hot Plate Test," International Journal of Sciences, Office ijSciences, vol. 6(06), pages 36-44, June.
    2. Nsonde Ntandou GF & N’Goka V & N’Goka V & Boumba SL & A.A. Abena, 2018. "Chemical Screening, Acute Toxicity and Analgesic Effect of the Aqueous Extracts of Vitex madiensis Oliv. (Lamiaceae-Viticoïdeae) and Phytolacca dodecandra L’Hérit. (Phytolaccaceae) Leaves," International Journal of Sciences, Office ijSciences, vol. 7(01), pages 1-9, January.
    3. Carl Nathan, 2002. "Points of control in inflammation," Nature, Nature, vol. 420(6917), pages 846-852, December.
    Full references (including those not matched with items on IDEAS)

    Most related items

    These are the items that most often cite the same works as this one and are cited by the same works as this one.
    1. Angelo Moreno & Jaewoo Lee, 2017. "Scavenging Damage and Pathogen Associated Molecules," Current Trends in Biomedical Engineering & Biosciences, Juniper Publishers Inc., vol. 2(1), pages 7-9, March.
    2. Cristiane R. S. Câmara & Carlos A. Urrea & Vicki Schlegel, 2013. "Pinto Beans ( Phaseolus vulgaris L.) as a Functional Food: Implications on Human Health," Agriculture, MDPI, vol. 3(1), pages 1-22, February.
    3. NS Mahabal & BB Kaliwal, 2017. "In Vitro Anti-Inflammatory Activity of L-Asparaginase from Soil Rhizosphere Fungus Aspergillus tamarii," Current Trends in Biomedical Engineering & Biosciences, Juniper Publishers Inc., vol. 4(5), pages 80-84, May.
    4. Rami A Namas & John Bartels & Rosemary Hoffman & Derek Barclay & Timothy R Billiar & Ruben Zamora & Yoram Vodovotz, 2013. "Combined In Silico, In Vivo, and In Vitro Studies Shed Insights into the Acute Inflammatory Response in Middle-Aged Mice," PLOS ONE, Public Library of Science, vol. 8(7), pages 1-11, July.
    5. Valeria Cristina Bulgaru & Ana Maria Pertea & Iulian Alexandru Grosu & Andrei Cristian Anghel & Gina Cecilia Pistol & Daniela Eliza Marin & Anca Dinischiotu & Ionelia Taranu, 2023. "Effects and Underlying Mechanisms of Zearalenone Mycotoxin at Concentrations Close to the EC Recommendation on the Colon of Piglets after Weaning," Agriculture, MDPI, vol. 13(7), pages 1-19, July.
    6. Vincent Grote & Matthias Frühwirth & Helmut K. Lackner & Nandu Goswami & Markus Köstenberger & Rudolf Likar & Maximilian Moser, 2021. "Cardiorespiratory Interaction and Autonomic Sleep Quality Improve during Sleep in Beds Made from Pinus cembra (Stone Pine) Solid Wood," IJERPH, MDPI, vol. 18(18), pages 1-20, September.
    7. Zogopoulos Panagiotis & Venetikidis Anastasios & Vretakos Georgios & Rologis Dimitrios & Karavis Miltiades & Theocharis Stamatios, 2017. "Acupuncture- Mediated Activation of the Cholinergic Anti-Inflammatory Pathway- A Review of the Literature," Open Access Journal of Neurology & Neurosurgery, Juniper Publishers Inc., vol. 2(2), pages 21-23, January.

    Corrections

    All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:adm:journl:v:9:y:2020:i:9:p:1-15. See general information about how to correct material in RePEc.

    If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

    If CitEc recognized a bibliographic reference but did not link an item in RePEc to it, you can help with this form .

    If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.

    For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: Staff ijSciences (email available below). General contact details of provider: .

    Please note that corrections may take a couple of weeks to filter through the various RePEc services.

    IDEAS is a RePEc service. RePEc uses bibliographic data supplied by the respective publishers.