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Evaluation of Chenopodium album Linn. Crude Methanolic Leaf Extract for Central Antinociceptive Activity in Albino Mice using the Hot Plate Test

Author

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  • Sibusisiwe Magama
  • Asita Okorie Asita

Abstract

The aim of study was to evaluate the crude leaf extract of Chenopodium album for central antinociceptive activity using inbred NIH albino mice. No mortalities were observed during the 14 day period in any of the 4 groups of 5 mice per group orally given 1, 2, 3, and 5 g/kg bw respectively. It was therefore assumed that the LD50 was higher than 5 g/kg bw. Eddy’s hot plate test for antinociception using 0, 50, 100 and 150 mg/kg bw and standard drug Aspirin (150 mg/kg bw) orally administered revealed that both Aspirin and the extract at 100 and at 150mg/kg bw exhibited significant (P

Suggested Citation

  • Sibusisiwe Magama & Asita Okorie Asita, 2017. "Evaluation of Chenopodium album Linn. Crude Methanolic Leaf Extract for Central Antinociceptive Activity in Albino Mice using the Hot Plate Test," International Journal of Sciences, Office ijSciences, vol. 6(06), pages 36-44, June.
    • Handle: RePEc:adm:journl:v:6:y:2017:i:6:p:36-44
    DOI: 10.18483/ijSci.1310
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    Cited by:

    1. Sibusisiwe Magama & Asita Okorie Asita & Teboho Derrick Skundla, 2020. "Evaluation of Aster bakerianus Burtt Davy ex C.A. Sm. Crude Root Extract for Acute Antiinflammatory Activity in Rats," International Journal of Sciences, Office ijSciences, vol. 9(09), pages 1-15, September.

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