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Points of control in inflammation

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  • Carl Nathan

    (Weill Medical College of Cornell University)

Abstract

Inflammation is a complex set of interactions among soluble factors and cells that can arise in any tissue in response to traumatic, infectious, post-ischaemic, toxic or autoimmune injury. The process normally leads to recovery from infection and to healing, However, if targeted destruction and assisted repair are not properly phased, inflammation can lead to persistent tissue damage by leukocytes, lymphocytes or collagen. Inflammation may be considered in terms of its checkpoints, where binary or higher-order signals drive each commitment to escalate, go signals trigger stop signals, and molecules responsible for mediating the inflammatory response also suppress it, depending on timing and context. The non-inflammatory state does not arise passively from an absence of inflammatory stimuli; rather, maintenance of health requires the positive actions of specific gene products to suppress reactions to potentially inflammatory stimuli that do not warrant a full response.

Suggested Citation

  • Carl Nathan, 2002. "Points of control in inflammation," Nature, Nature, vol. 420(6917), pages 846-852, December.
    • Handle: RePEc:nat:nature:v:420:y:2002:i:6917:d:10.1038_nature01320
    DOI: 10.1038/nature01320
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    Cited by:

    1. NS Mahabal & BB Kaliwal, 2017. "In Vitro Anti-Inflammatory Activity of L-Asparaginase from Soil Rhizosphere Fungus Aspergillus tamarii," Current Trends in Biomedical Engineering & Biosciences, Juniper Publishers Inc., vol. 4(5), pages 80-84, May.
    2. Vincent Grote & Matthias Frühwirth & Helmut K. Lackner & Nandu Goswami & Markus Köstenberger & Rudolf Likar & Maximilian Moser, 2021. "Cardiorespiratory Interaction and Autonomic Sleep Quality Improve during Sleep in Beds Made from Pinus cembra (Stone Pine) Solid Wood," IJERPH, MDPI, vol. 18(18), pages 1-20, September.
    3. Angelo Moreno & Jaewoo Lee, 2017. "Scavenging Damage and Pathogen Associated Molecules," Current Trends in Biomedical Engineering & Biosciences, Juniper Publishers Inc., vol. 2(1), pages 7-9, March.
    4. Cristiane R. S. Câmara & Carlos A. Urrea & Vicki Schlegel, 2013. "Pinto Beans ( Phaseolus vulgaris L.) as a Functional Food: Implications on Human Health," Agriculture, MDPI, vol. 3(1), pages 1-22, February.
    5. Zogopoulos Panagiotis & Venetikidis Anastasios & Vretakos Georgios & Rologis Dimitrios & Karavis Miltiades & Theocharis Stamatios, 2017. "Acupuncture- Mediated Activation of the Cholinergic Anti-Inflammatory Pathway- A Review of the Literature," Open Access Journal of Neurology & Neurosurgery, Juniper Publishers Inc., vol. 2(2), pages 21-23, January.
    6. Sibusisiwe Magama & Asita Okorie Asita & Teboho Derrick Skundla, 2020. "Evaluation of Aster bakerianus Burtt Davy ex C.A. Sm. Crude Root Extract for Acute Antiinflammatory Activity in Rats," International Journal of Sciences, Office ijSciences, vol. 9(09), pages 1-15, September.
    7. Valeria Cristina Bulgaru & Ana Maria Pertea & Iulian Alexandru Grosu & Andrei Cristian Anghel & Gina Cecilia Pistol & Daniela Eliza Marin & Anca Dinischiotu & Ionelia Taranu, 2023. "Effects and Underlying Mechanisms of Zearalenone Mycotoxin at Concentrations Close to the EC Recommendation on the Colon of Piglets after Weaning," Agriculture, MDPI, vol. 13(7), pages 1-19, July.
    8. Rami A Namas & John Bartels & Rosemary Hoffman & Derek Barclay & Timothy R Billiar & Ruben Zamora & Yoram Vodovotz, 2013. "Combined In Silico, In Vivo, and In Vitro Studies Shed Insights into the Acute Inflammatory Response in Middle-Aged Mice," PLOS ONE, Public Library of Science, vol. 8(7), pages 1-11, July.

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