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Chemical Screening, Acute Toxicity and Analgesic Effect of the Aqueous Extracts of Vitex madiensis Oliv. (Lamiaceae-Viticoïdeae) and Phytolacca dodecandra L’Hérit. (Phytolaccaceae) Leaves

Author

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  • Nsonde Ntandou GF
  • N’Goka V
  • N’Goka V
  • Boumba SL
  • A.A. Abena

Abstract

The purpose of this study is to identify the various secondary metabolites and evaluate the toxicity and analgesic activity of Vitex madiensis Oliv.(VM) and Phytolacca dodecandra L’Hérit.(PD) aqueous extracts two plants used in traditional medicine in Congo for the management of pain and other conditions. Phytochemical analysis ,by using tube reaction method, revealed very strong presence of saponins, strong presence of alkaloids and tannins from PD; strong presence of tannins, sterols and tri-terpenes from VM. Standard procedures using OECD Guideline helped to consider the VM extract non-toxic with an LD50 greater than 5000 mg / kg and the PD extract low toxic with an LD50 greater than 2000 g / kg in mice. Extracts promote an increase in body mass. Extracts tested at the doses of 50, 100 and 200 mg / kg inhibit significantly (p

Suggested Citation

  • Nsonde Ntandou GF & N’Goka V & N’Goka V & Boumba SL & A.A. Abena, 2018. "Chemical Screening, Acute Toxicity and Analgesic Effect of the Aqueous Extracts of Vitex madiensis Oliv. (Lamiaceae-Viticoïdeae) and Phytolacca dodecandra L’Hérit. (Phytolaccaceae) Leaves," International Journal of Sciences, Office ijSciences, vol. 7(01), pages 1-9, January.
    • Handle: RePEc:adm:journl:v:7:y:2018:i:1:p:1-9
    DOI: 10.18483/ijSci.1261
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    Cited by:

    1. Sibusisiwe Magama & Asita Okorie Asita & Teboho Derrick Skundla, 2020. "Evaluation of Aster bakerianus Burtt Davy ex C.A. Sm. Crude Root Extract for Acute Antiinflammatory Activity in Rats," International Journal of Sciences, Office ijSciences, vol. 9(09), pages 1-15, September.

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