IDEAS home Printed from https://ideas.repec.org/p/osf/socarx/u7sh4.html
   My bibliography  Save this paper

Interactions between polygenic scores and environments: Methodological and conceptual challenges

Author

Listed:
  • Domingue, Benjamin
  • Trejo, Sam
  • Armstrong-Carter, Emma
  • Tucker-Drob, Elliot M.

    (University of Texas at Austin)

Abstract

Interest in the study of gene-environment interaction has recently grown due to the sudden availability of molecular genetic data—in particular, polygenic scores—in many long-running cohort studies. Identifying and estimating statistical interactions comes with several analytic and inferential challenges; these challenges are heightened when used to integrate observational genomic and social science data. We articulate some of these key challenges, provide new perspectives on the study of gene-environment interactions, and finally offer some practical guidance for conducting research in this area. Given the sudden availability of well-powered polygenic scores, we anticipate a substantial increase in research testing for interaction between such scores and environments. The issues we discuss, if not properly addressed, may impact the enduring scientific value of gene-environment interaction studies.

Suggested Citation

  • Domingue, Benjamin & Trejo, Sam & Armstrong-Carter, Emma & Tucker-Drob, Elliot M., 2020. "Interactions between polygenic scores and environments: Methodological and conceptual challenges," SocArXiv u7sh4, Center for Open Science.
    • Handle: RePEc:osf:socarx:u7sh4
    DOI: 10.31219/osf.io/u7sh4
    as

    Download full text from publisher

    File URL: https://osf.io/download/5ecd17ffaeeb6d01b6083ffe/
    Download Restriction: no
    File URL: https://libkey.io/10.31219/osf.io/u7sh4?utm_source=ideas
    LibKey link: if access is restricted and if your library uses this service, LibKey will redirect you to where you can use your library subscription to access this item
    ---><---

    References listed on IDEAS

    as
    1. repec:nas:journl:v:115:y:2018:p:e9765-e9772 is not listed on IDEAS
    2. Barr, Peter B. & Silberg, Judy & Dick, Danielle M. & Maes, Hermine H., 2018. "Childhood socioeconomic status and longitudinal patterns of alcohol problems: Variation across etiological pathways in genetic risk," Social Science & Medicine, Elsevier, vol. 209(C), pages 51-58.
    3. Boardman, J.D. & Daw, J. & Freese, J., 2013. "Defining the environment in gene-environment research: Lessons from social epidemiology," American Journal of Public Health, American Public Health Association, vol. 103(SUPPL.1), pages 64-72.
    4. repec:nas:journl:v:115:y:2018:p:e4970-e4979 is not listed on IDEAS
    5. Felix C. Tropf & S. Hong Lee & Renske M. Verweij & Gert Stulp & Peter J. van der Most & Ronald de Vlaming & Andrew Bakshi & Daniel A. Briley & Charles Rahal & Robert Hellpap & Anastasia N. Iliadou & T, 2017. "Hidden heritability due to heterogeneity across seven populations," Nature Human Behaviour, Nature, vol. 1(10), pages 757-765, October.
    6. Chabris, C. F. & Lee, J. J. & Cesarini, D. & Benjamin, D. J. & Laibson, David I., 2015. "The Fourth Law of Behavior Genetics," Scholarly Articles 30780203, Harvard University Department of Economics.
    Full references (including those not matched with items on IDEAS)

    Citations

    Citations are extracted by the CitEc Project, subscribe to its RSS feed for this item.
    as


    Cited by:

    1. von Stumm, Sophie & Nancarrow, Allie F., 2024. "New methods, persistent issues, and one solution: Gene-environment interaction studies of childhood cognitive development," Intelligence, Elsevier, vol. 105(C).
    2. Samuel Baker & Pietro Biroli & Hans van Kippersluis & Stephanie von Hinke, 2022. "Beyond Barker: Infant Mortality at Birth and Ischaemic Heart Disease in Older Age," Working Papers 2022-015, Human Capital and Economic Opportunity Working Group.
    3. Pietro Biroli & Titus Galama & Stephanie von Hinke & Hans van Kippersluis & Cornelius Rietveld & Kevin Thom, 2022. "The Economics and Econometrics of Gene-Environment Interplay," Tinbergen Institute Discussion Papers 22-019/V, Tinbergen Institute.
    4. Gueltzow, Maria & Lahtinen, Hannu & Bijlsma, Maarten J. & Myrskylä, Mikko & Martikainen, Pekka, 2024. "Genetic propensity to depression and the role of partnership status," Social Science & Medicine, Elsevier, vol. 351(C).
    5. Das, Aniruddha, 2021. "The relational genomics of cognitive function: A longitudinal study," Social Science & Medicine, Elsevier, vol. 270(C).
    6. Rita Dias Pereira & Pietro Biroli & Titus Galama & Stephanie von Hinke & Hans van Kippersluis & Cornelius A. Rietveld & Kevin Thom, 2022. "Gene-Environment Interplay in the Social Sciences," Papers 2203.02198, arXiv.org, revised Aug 2022.
    7. Trejo, Sam, 2020. "Exploring Genetic Influences on Birth Weight," SocArXiv 7j59q, Center for Open Science.

    Most related items

    These are the items that most often cite the same works as this one and are cited by the same works as this one.
    1. Pietro Biroli & Titus Galama & Stephanie von Hinke & Hans van Kippersluis & Kevin Thom, 2022. "Economics and Econometrics of Gene-Environment Interplay," Bristol Economics Discussion Papers 22/759, School of Economics, University of Bristol, UK.
    2. Pereira, Rita & Biroli, Pietro & von hinke, stephanie & Van Kippersluis, Hans & Galama, Titus & Rietveld, Niels & Thom, Kevin, 2022. "Gene-Environment Interplay in the Social Sciences," OSF Preprints d96z3, Center for Open Science.
    3. von Stumm, Sophie & Nancarrow, Allie F., 2024. "New methods, persistent issues, and one solution: Gene-environment interaction studies of childhood cognitive development," Intelligence, Elsevier, vol. 105(C).
    4. Hans Kippersluis & Pietro Biroli & Rita Dias Pereira & Titus J. Galama & Stephanie Hinke & S. Fleur W. Meddens & Dilnoza Muslimova & Eric A. W. Slob & Ronald Vlaming & Cornelius A. Rietveld, 2023. "Overcoming attenuation bias in regressions using polygenic indices," Nature Communications, Nature, vol. 14(1), pages 1-16, December.
    5. Guo, Fangqi & Harris, Kathleen Mullan & Boardman, Jason D. & Robinette, Jennifer W., 2022. "Does crime trigger genetic risk for type 2 diabetes in young adults? A G x E interaction study using national data," Social Science & Medicine, Elsevier, vol. 313(C).
    6. Dilnoza Muslimova & Hans van Kippersluis & Cornelius A. Rietveld & Stephanie von Hinke & S. Fleur W. Meddens, 2020. "Nature-nurture interplay in educational attainment," Papers 2012.05021, arXiv.org, revised Jul 2023.
    7. Nicola Barban & Elisabetta De Cao & Marco Francesconi, 2021. "Gene-Environment Effects on Female Fertility," CESifo Working Paper Series 9337, CESifo.
    8. Gören, Erkan, 2017. "The persistent effects of novelty-seeking traits on comparative economic development," Journal of Development Economics, Elsevier, vol. 126(C), pages 112-126.
    9. Dixon, Padraig & Hollingworth, William & Harrison, Sean & Davies, Neil M. & Davey Smith, George, 2020. "Mendelian Randomization analysis of the causal effect of adiposity on hospital costs," Journal of Health Economics, Elsevier, vol. 70(C).
    10. Xu, Yilan & Briley, Daniel A. & Brown, Jeffrey R. & Roberts, Brent W., 2017. "Genetic and environmental influences on household financial distress," Journal of Economic Behavior & Organization, Elsevier, vol. 142(C), pages 404-424.
    11. Krammer, Sorin M.S. & Gören, Erkan, 2021. "Wired in? Genetic traits and entrepreneurship around the world," Technological Forecasting and Social Change, Elsevier, vol. 168(C).
    12. Graciela Kuechle, 2019. "The contribution of behavior genetics to entrepreneurship: An evolutionary perspective," Journal of Evolutionary Economics, Springer, vol. 29(4), pages 1263-1284, September.
    13. Kettlewell, Nathan & Tymula, Agnieszka & Yoo, Hong Il, 2023. "The Heritability of Economic Preferences," IZA Discussion Papers 16633, Institute of Labor Economics (IZA).
    14. Cornelius A. Rietveld & Eric A.W. Slob & A. Roy Thurik, 2021. "A decade of research on the genetics of entrepreneurship: a review and view ahead," Small Business Economics, Springer, vol. 57(3), pages 1303-1317, October.
    15. Md. Moksedul Momin & Jisu Shin & Soohyun Lee & Buu Truong & Beben Benyamin & S. Hong Lee, 2023. "A method for an unbiased estimate of cross-ancestry genetic correlation using individual-level data," Nature Communications, Nature, vol. 14(1), pages 1-13, December.
    16. W. Carson Byrd & Matthew W. Hughey, 2015. "Biological Determinism and Racial Essentialism," The ANNALS of the American Academy of Political and Social Science, , vol. 661(1), pages 8-22, September.
    17. Dierker, Philipp & Kühn, Mine & Mönkediek, Bastian, 2023. "Does parental separation moderate the heritability of health risk behavior among adolescents?," Social Science & Medicine, Elsevier, vol. 331(C).
    18. Brian B. Boutwell & Eric J. Connolly, 2017. "On the Heritability of Criminal Justice Processing," SAGE Open, , vol. 7(3), pages 21582440177, July.
    19. Nagel, Mats, 2020. "Changing perspectives: Towards detailed phenotyping in genetics," Thesis Commons a4nz2, Center for Open Science.
    20. Lee, James J. & McGue, Matt & Iacono, William G. & Michael, Andrew M. & Chabris, Christopher F., 2019. "The causal influence of brain size on human intelligence: Evidence from within-family phenotypic associations and GWAS modeling," Intelligence, Elsevier, vol. 75(C), pages 48-58.

    More about this item

    NEP fields

    This paper has been announced in the following NEP Reports:

    Statistics

    Access and download statistics

    Corrections

    All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:osf:socarx:u7sh4. See general information about how to correct material in RePEc.

    If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

    If CitEc recognized a bibliographic reference but did not link an item in RePEc to it, you can help with this form .

    If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.

    For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: OSF (email available below). General contact details of provider: https://arabixiv.org .

    Please note that corrections may take a couple of weeks to filter through the various RePEc services.

    IDEAS is a RePEc service. RePEc uses bibliographic data supplied by the respective publishers.