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Childhood socioeconomic status and longitudinal patterns of alcohol problems: Variation across etiological pathways in genetic risk

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  • Barr, Peter B.
  • Silberg, Judy
  • Dick, Danielle M.
  • Maes, Hermine H.

Abstract

Childhood socioeconomic status (SES) is an important aspect of early life environment associated with later life health/health behaviors, including alcohol misuse. However, alcohol misuse is modestly heritable and involves differing etiological pathways. Externalizing disorders show significant genetic overlap with substance use, suggesting an impulsivity pathway to alcohol misuse. Alcohol misuse also overlaps with internalizing disorders, suggesting alcohol is used to cope. These differing pathways could lead to different patterns over time and/or differential susceptibility to environmental conditions, such as childhood SES. We examine whether: 1) genetic risk for externalizing and internalizing disorders influence trajectories of alcohol problems across adolescence to adulthood, 2) childhood SES alters genetic risk these disorders on trajectories of alcohol problems, and 3) these patterns are consistent across sex. We find modest evidence of gene-environment interaction. Higher childhood SES increases the risk of alcohol problems in late adolescence/early adulthood, while lower childhood SES increases the risk of alcohol problems in later adulthood, but only among males at greater genetic risk of externalizing disorders. Females from lower SES families with higher genetic risk of internalizing or externalizing disorders have greater risk of developing alcohol problems.

Suggested Citation

  • Barr, Peter B. & Silberg, Judy & Dick, Danielle M. & Maes, Hermine H., 2018. "Childhood socioeconomic status and longitudinal patterns of alcohol problems: Variation across etiological pathways in genetic risk," Social Science & Medicine, Elsevier, vol. 209(C), pages 51-58.
    • Handle: RePEc:eee:socmed:v:209:y:2018:i:c:p:51-58
    DOI: 10.1016/j.socscimed.2018.05.027
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    Cited by:

    1. Domingue, Benjamin & Trejo, Sam & Armstrong-Carter, Emma & Tucker-Drob, Elliot M., 2020. "Interactions between polygenic scores and environments: Methodological and conceptual challenges," SocArXiv u7sh4, Center for Open Science.
    2. Lee, Chioun & Ryff, Carol D., 2019. "Pathways linking combinations of early-life adversities to adult mortality: Tales that vary by gender," Social Science & Medicine, Elsevier, vol. 240(C).
    3. Dierker, Philipp & Kühn, Mine & Mönkediek, Bastian, 2023. "Does parental separation moderate the heritability of health risk behavior among adolescents?," Social Science & Medicine, Elsevier, vol. 331(C).
    4. Pilar Marqués-Sánchez & Enedina Quiroga Sánchez & Cristina Liébana-Presa & Elena Fernández-Martínez & Isaías García-Rodríguez & José Alberto Benítez-Andrades, 2020. "The consumption of alcohol by adolescent schoolchildren: Differences in the triadic relationship pattern between rural and urban environments," PLOS ONE, Public Library of Science, vol. 15(11), pages 1-12, November.
    5. Lucía Martínez-Manrique & Maitane Berasaluce & Xisca Sureda & María Sandín Vázquez, 2022. "Gender Matters: Identity, Risk Perception and Preventive Interventions for Alcohol Consumption among Adolescents Using a Qualitative Approach," IJERPH, MDPI, vol. 19(24), pages 1-18, December.
    6. Muhammad Akbar & Abid Rashid & Dr. Muhammad Ramzan Sheikh, 2024. "Socioeconomic Determinants of Genetic Disorder in Disabled Persons of Punjab, Pakistan," Bulletin of Business and Economics (BBE), Research Foundation for Humanity (RFH), vol. 13(1), pages 29-41.

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