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The Current Drug Development Paradigm: Responding to US and European Demands for Evidence of Comparative Effectiveness and Relative Effectiveness

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  • Jorge Mestre-Ferrandiz;Patricia Deverka;Michele Pistollato;Emily Rosenberg

Abstract

The project reported in this Occasional Paper was intended to determine how changing demands for evidence are affecting drug development in five global pharmaceutical companies: Amgen, Eli Lilly, GSK, Novartis and Sanofi-Aventis. A literature review helped elucidate concepts and define focus. The authors then conducted semi-structured interviews with an international sample of 19 senior pharmaceutical executives in various positions in the five companies: R&D, outcomes research, medical affairs, and pricing and reimbursement. The intent was to capture information about the effect of CER/RE requirements on the drug development process now and in the future.

Suggested Citation

  • Jorge Mestre-Ferrandiz;Patricia Deverka;Michele Pistollato;Emily Rosenberg, 2014. "The Current Drug Development Paradigm: Responding to US and European Demands for Evidence of Comparative Effectiveness and Relative Effectiveness," Occasional Paper 000076, Office of Health Economics.
    • Handle: RePEc:ohe:occpap:000076
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    References listed on IDEAS

    as
    1. Jorge Mestre-Ferrandiz;Jon Sussex;Adrian Towse, 2012. "The R&D Cost of a New Medicine," Monograph 000135, Office of Health Economics.
    2. James Chambers, 2014. "Can the US Afford to Ignore Cost-effectiveness Evidence?," Seminar Briefing 000074, Office of Health Economics.
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