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A Functional Approach to Deconvolve Dynamic Neuroimaging Data

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  • Ci-Ren Jiang
  • John A. D. Aston
  • Jane-Ling Wang

Abstract

Positron emission tomography (PET) is an imaging technique which can be used to investigate chemical changes in human biological processes such as cancer development or neurochemical reactions. Most dynamic PET scans are currently analyzed based on the assumption that linear first-order kinetics can be used to adequately describe the system under observation. However, there has recently been strong evidence that this is not the case. To provide an analysis of PET data which is free from this compartmental assumption, we propose a nonparametric deconvolution and analysis model for dynamic PET data based on functional principal component analysis. This yields flexibility in the possible deconvolved functions while still performing well when a linear compartmental model setup is the true data generating mechanism. As the deconvolution needs to be performed on only a relative small number of basis functions rather than voxel by voxel in the entire three-dimensional volume, the methodology is both robust to typical brain imaging noise levels while also being computationally efficient. The new methodology is investigated through simulations in both one-dimensional functions and 2D images and also applied to a neuroimaging study whose goal is the quantification of opioid receptor concentration in the brain.

Suggested Citation

  • Ci-Ren Jiang & John A. D. Aston & Jane-Ling Wang, 2016. "A Functional Approach to Deconvolve Dynamic Neuroimaging Data," Journal of the American Statistical Association, Taylor & Francis Journals, vol. 111(513), pages 1-13, March.
    • Handle: RePEc:taf:jnlasa:v:111:y:2016:i:513:p:1-13
    DOI: 10.1080/01621459.2015.1060241
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    References listed on IDEAS

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    1. Dauxois, J. & Pousse, A. & Romain, Y., 1982. "Asymptotic theory for the principal component analysis of a vector random function: Some applications to statistical inference," Journal of Multivariate Analysis, Elsevier, vol. 12(1), pages 136-154, March.
    2. Boente, Graciela & Fraiman, Ricardo, 2000. "Kernel-based functional principal components," Statistics & Probability Letters, Elsevier, vol. 48(4), pages 335-345, July.
    3. O'Sullivan, Finbarr & Muzi, Mark & Spence, Alexander M. & Mankoff, David M. & O'Sullivan, Janet N. & Fitzgerald, Niall & Newman, George C. & Krohn, Kenneth A., 2009. "Nonparametric Residue Analysis of Dynamic PET Data With Application to Cerebral FDG Studies in Normals," Journal of the American Statistical Association, American Statistical Association, vol. 104(486), pages 556-571.
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    Cited by:

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    2. Pircalabelu, Eugen & Claeskens, Gerda, 2021. "Linear manifold modeling and graph estimation based on multivariate functional data with different coarseness scales," LIDAM Discussion Papers ISBA 2021032, Université catholique de Louvain, Institute of Statistics, Biostatistics and Actuarial Sciences (ISBA).
    3. Adam B. Kashlak & John A. D. Aston & Richard Nickl, 2019. "Inference on Covariance Operators via Concentration Inequalities: k-sample Tests, Classification, and Clustering via Rademacher Complexities," Sankhya A: The Indian Journal of Statistics, Springer;Indian Statistical Institute, vol. 81(1), pages 214-243, February.

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