IDEAS home Printed from https://ideas.repec.org/a/taf/jnlasa/v111y2016i513p1-13.html
   My bibliography  Save this article

A Functional Approach to Deconvolve Dynamic Neuroimaging Data

Author

Listed:
  • Ci-Ren Jiang
  • John A. D. Aston
  • Jane-Ling Wang

Abstract

Positron emission tomography (PET) is an imaging technique which can be used to investigate chemical changes in human biological processes such as cancer development or neurochemical reactions. Most dynamic PET scans are currently analyzed based on the assumption that linear first-order kinetics can be used to adequately describe the system under observation. However, there has recently been strong evidence that this is not the case. To provide an analysis of PET data which is free from this compartmental assumption, we propose a nonparametric deconvolution and analysis model for dynamic PET data based on functional principal component analysis. This yields flexibility in the possible deconvolved functions while still performing well when a linear compartmental model setup is the true data generating mechanism. As the deconvolution needs to be performed on only a relative small number of basis functions rather than voxel by voxel in the entire three-dimensional volume, the methodology is both robust to typical brain imaging noise levels while also being computationally efficient. The new methodology is investigated through simulations in both one-dimensional functions and 2D images and also applied to a neuroimaging study whose goal is the quantification of opioid receptor concentration in the brain.

Suggested Citation

  • Ci-Ren Jiang & John A. D. Aston & Jane-Ling Wang, 2016. "A Functional Approach to Deconvolve Dynamic Neuroimaging Data," Journal of the American Statistical Association, Taylor & Francis Journals, vol. 111(513), pages 1-13, March.
    • Handle: RePEc:taf:jnlasa:v:111:y:2016:i:513:p:1-13
    DOI: 10.1080/01621459.2015.1060241
    as

    Download full text from publisher

    File URL: http://hdl.handle.net/10.1080/01621459.2015.1060241
    Download Restriction: Access to full text is restricted to subscribers.
    File URL: https://libkey.io/10.1080/01621459.2015.1060241?utm_source=ideas
    LibKey link: if access is restricted and if your library uses this service, LibKey will redirect you to where you can use your library subscription to access this item
    ---><---

    As the access to this document is restricted, you may want to search for a different version of it.

    References listed on IDEAS

    as
    1. Dauxois, J. & Pousse, A. & Romain, Y., 1982. "Asymptotic theory for the principal component analysis of a vector random function: Some applications to statistical inference," Journal of Multivariate Analysis, Elsevier, vol. 12(1), pages 136-154, March.
    2. Boente, Graciela & Fraiman, Ricardo, 2000. "Kernel-based functional principal components," Statistics & Probability Letters, Elsevier, vol. 48(4), pages 335-345, July.
    3. O'Sullivan, Finbarr & Muzi, Mark & Spence, Alexander M. & Mankoff, David M. & O'Sullivan, Janet N. & Fitzgerald, Niall & Newman, George C. & Krohn, Kenneth A., 2009. "Nonparametric Residue Analysis of Dynamic PET Data With Application to Cerebral FDG Studies in Normals," Journal of the American Statistical Association, American Statistical Association, vol. 104(486), pages 556-571.
    Full references (including those not matched with items on IDEAS)

    Citations

    Citations are extracted by the CitEc Project, subscribe to its RSS feed for this item.
    as


    Cited by:

    1. Wong, Raymond K.W. & Zhang, Xiaoke, 2019. "Nonparametric operator-regularized covariance function estimation for functional data," Computational Statistics & Data Analysis, Elsevier, vol. 131(C), pages 131-144.
    2. Pircalabelu, Eugen & Claeskens, Gerda, 2021. "Linear manifold modeling and graph estimation based on multivariate functional data with different coarseness scales," LIDAM Discussion Papers ISBA 2021032, Université catholique de Louvain, Institute of Statistics, Biostatistics and Actuarial Sciences (ISBA).
    3. Adam B. Kashlak & John A. D. Aston & Richard Nickl, 2019. "Inference on Covariance Operators via Concentration Inequalities: k-sample Tests, Classification, and Clustering via Rademacher Complexities," Sankhya A: The Indian Journal of Statistics, Springer;Indian Statistical Institute, vol. 81(1), pages 214-243, February.

    Most related items

    These are the items that most often cite the same works as this one and are cited by the same works as this one.
    1. Boente, Graciela & Rodriguez, Daniela & Sued, Mariela, 2010. "Inference under functional proportional and common principal component models," Journal of Multivariate Analysis, Elsevier, vol. 101(2), pages 464-475, February.
    2. Kyunghee Han & Pantelis Z Hadjipantelis & Jane-Ling Wang & Michael S Kramer & Seungmi Yang & Richard M Martin & Hans-Georg Müller, 2018. "Functional principal component analysis for identifying multivariate patterns and archetypes of growth, and their association with long-term cognitive development," PLOS ONE, Public Library of Science, vol. 13(11), pages 1-18, November.
    3. Lakraj, Gamage Pemantha & Ruymgaart, Frits, 2017. "Some asymptotic theory for Silverman’s smoothed functional principal components in an abstract Hilbert space," Journal of Multivariate Analysis, Elsevier, vol. 155(C), pages 122-132.
    4. Bali, Juan Lucas & Boente, Graciela, 2014. "Consistency of a numerical approximation to the first principal component projection pursuit estimator," Statistics & Probability Letters, Elsevier, vol. 94(C), pages 181-191.
    5. Park, Juhyun & Gasser, Theo & Rousson, Valentin, 2009. "Structural components in functional data," Computational Statistics & Data Analysis, Elsevier, vol. 53(9), pages 3452-3465, July.
    6. van der Linde, Angelika, 2008. "Variational Bayesian functional PCA," Computational Statistics & Data Analysis, Elsevier, vol. 53(2), pages 517-533, December.
    7. Graciela Boente & Daniela Rodriguez & Mariela Sued, 2018. "Testing equality between several populations covariance operators," Annals of the Institute of Statistical Mathematics, Springer;The Institute of Statistical Mathematics, vol. 70(4), pages 919-950, August.
    8. repec:cte:wsrepe:ws1506 is not listed on IDEAS
    9. María Edo & Walter Sosa Escudero & Marcela Svarc, 2021. "A multidimensional approach to measuring the middle class," The Journal of Economic Inequality, Springer;Society for the Study of Economic Inequality, vol. 19(1), pages 139-162, March.
    10. Jarry, Gabriel & Delahaye, Daniel & Nicol, Florence & Feron, Eric, 2020. "Aircraft atypical approach detection using functional principal component analysis," Journal of Air Transport Management, Elsevier, vol. 84(C).
    11. Guangxing Wang & Sisheng Liu & Fang Han & Chong‐Zhi Di, 2023. "Robust functional principal component analysis via a functional pairwise spatial sign operator," Biometrics, The International Biometric Society, vol. 79(2), pages 1239-1253, June.
    12. repec:hum:wpaper:sfb649dp2006-010 is not listed on IDEAS
    13. Poskitt, D.S. & Sengarapillai, Arivalzahan, 2013. "Description length and dimensionality reduction in functional data analysis," Computational Statistics & Data Analysis, Elsevier, vol. 58(C), pages 98-113.
    14. van Delft, Anne, 2020. "A note on quadratic forms of stationary functional time series under mild conditions," Stochastic Processes and their Applications, Elsevier, vol. 130(7), pages 4206-4251.
    15. Bali, Juan Lucas & Boente, Graciela, 2015. "Influence function of projection-pursuit principal components for functional data," Journal of Multivariate Analysis, Elsevier, vol. 133(C), pages 173-199.
    16. Qi, Xin & Zhao, Hongyu, 2011. "Some theoretical properties of Silverman's method for Smoothed functional principal component analysis," Journal of Multivariate Analysis, Elsevier, vol. 102(4), pages 741-767, April.
    17. Delsol, Laurent & Ferraty, Frédéric & Vieu, Philippe, 2011. "Structural test in regression on functional variables," Journal of Multivariate Analysis, Elsevier, vol. 102(3), pages 422-447, March.
    18. repec:hum:wpaper:sfb649dp2005-016 is not listed on IDEAS
    19. Berrendero, J.R. & Justel, A. & Svarc, M., 2011. "Principal components for multivariate functional data," Computational Statistics & Data Analysis, Elsevier, vol. 55(9), pages 2619-2634, September.
    20. Beran, Jan & Liu, Haiyan, 2016. "Estimation of eigenvalues, eigenvectors and scores in FDA models with dependent errors," Journal of Multivariate Analysis, Elsevier, vol. 147(C), pages 218-233.
    21. Chung Chang & Yakuan Chen & R. Ogden, 2014. "Functional data classification: a wavelet approach," Computational Statistics, Springer, vol. 29(6), pages 1497-1513, December.
    22. Yuping Hu & Siyu Wu & Sanying Feng & Junliang Jin, 2020. "Estimation in Partial Functional Linear Spatial Autoregressive Model," Mathematics, MDPI, vol. 8(10), pages 1-12, October.
    23. Biau Gérard & Mas André, 2012. "PCA-kernel estimation," Statistics & Risk Modeling, De Gruyter, vol. 29(1), pages 19-46, March.

    More about this item

    Statistics

    Access and download statistics

    Corrections

    All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:taf:jnlasa:v:111:y:2016:i:513:p:1-13. See general information about how to correct material in RePEc.

    If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

    If CitEc recognized a bibliographic reference but did not link an item in RePEc to it, you can help with this form .

    If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.

    For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: Chris Longhurst (email available below). General contact details of provider: http://www.tandfonline.com/UASA20 .

    Please note that corrections may take a couple of weeks to filter through the various RePEc services.

    IDEAS is a RePEc service. RePEc uses bibliographic data supplied by the respective publishers.