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Semiparametric models of longitudinal and time-to-event data with applications to HIV viral dynamics and CD4 counts

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  • Xiaobing Zhao
  • Xian Zhou

Abstract

We propose a semiparametric approach based on proportional hazards and copula method to jointly model longitudinal outcomes and the time-to-event. The dependence between the longitudinal outcomes on the covariates is modeled by a copula-based times series, which allows non-Gaussian random effects and overcomes the limitation of the parametric assumptions in existing linear and nonlinear random effects models. A modified partial likelihood method using estimated covariates at failure times is employed to draw statistical inference. The proposed model and method are applied to analyze a set of progression to AIDS data in a study of the association between the human immunodeficiency virus viral dynamics and the time trend in the CD4/CD8 ratio with measurement errors. Simulations are also reported to evaluate the proposed model and method.

Suggested Citation

  • Xiaobing Zhao & Xian Zhou, 2015. "Semiparametric models of longitudinal and time-to-event data with applications to HIV viral dynamics and CD4 counts," Journal of Applied Statistics, Taylor & Francis Journals, vol. 42(11), pages 2461-2477, November.
    • Handle: RePEc:taf:japsta:v:42:y:2015:i:11:p:2461-2477
    DOI: 10.1080/02664763.2015.1043859
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    References listed on IDEAS

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    1. Wen Ye & Xihong Lin & Jeremy M. G. Taylor, 2008. "Semiparametric Modeling of Longitudinal Measurements and Time-to-Event Data–A Two-Stage Regression Calibration Approach," Biometrics, The International Biometric Society, vol. 64(4), pages 1238-1246, December.
    2. Xiao Song & Marie Davidian & Anastasios A. Tsiatis, 2002. "A Semiparametric Likelihood Approach to Joint Modeling of Longitudinal and Time-to-Event Data," Biometrics, The International Biometric Society, vol. 58(4), pages 742-753, December.
    3. Genest, Christian & Rémillard, Bruno & Beaudoin, David, 2009. "Goodness-of-fit tests for copulas: A review and a power study," Insurance: Mathematics and Economics, Elsevier, vol. 44(2), pages 199-213, April.
    4. J. Fan & J.‐T. Zhang, 2000. "Two‐step estimation of functional linear models with applications to longitudinal data," Journal of the Royal Statistical Society Series B, Royal Statistical Society, vol. 62(2), pages 303-322.
    5. Els Goetghebeur & Louise Ryan, 2000. "Semiparametric Regression Analysis of Interval-Censored Data," Biometrics, The International Biometric Society, vol. 56(4), pages 1139-1144, December.
    6. Edward Frees & Emiliano Valdez, 1998. "Understanding Relationships Using Copulas," North American Actuarial Journal, Taylor & Francis Journals, vol. 2(1), pages 1-25.
    7. Wu L., 2002. "A Joint Model for Nonlinear Mixed-Effects Models With Censoring and Covariates Measured With Error, With Application to AIDS Studies," Journal of the American Statistical Association, American Statistical Association, vol. 97, pages 955-964, December.
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