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Cancer-Specific Health Utilities: Evaluation of Core Measurement Properties of the EORTC QLU-C10D in Lung Cancer Patients—Data from Four Multicentre LUX-Lung Trials, Applying Six Country Tariffs

Author

Listed:
  • Micha J. Pilz

    (Medical University of Innsbruck)

  • Simone Seyringer

    (Medical University of Innsbruck)

  • Imad Al-Naesan

    (Medical University of Innsbruck)

  • Madeleine T. King

    (University of Sydney)

  • Andrew Bottomley

    (European Organisation for Research and Treatment of Cancer)

  • Richard Norman

    (Curtin University)

  • Lisa Schlosser

    (University of Innsbruck)

  • Tobias Hell

    (University of Innsbruck)

  • Eva Maria Gamper

    (Medical University of Innsbruck)

Abstract

Background Cost-utility analysis generally requires valid preference-based measures (PBMs) to assess the utility of patient health. While generic PBMs are widely used, disease-specific PBMs may capture additional aspects of health relevant for certain patient populations. This study investigates the construct and concurrent criterion validity of the cancer-specific European Organisation for Research and Treatment of Cancer (EORTC) Quality of Life Utility-Core 10 dimensions (QLU-C10D) in non-small-cell lung cancer patients. Methods We retrospectively analysed data from four multicentre LUX-Lung trials, all of which had administered the EORTC Quality of Life Questionnaire (QLQ-C30) and the EQ-5D-3L. We applied six country-specific value sets (Australia, Canada, Italy, the Netherlands, Poland, and the United Kingdom) to both instruments. Criterion validity was assessed via correlations between the instruments’ utility scores. Correlations of divergent and convergent domains and Bland-Altman plots investigated construct validity. Floor and ceiling effects were assessed. Results The comparison of the EORTC QLU-C10D and EQ-5D-3L produced homogenous results for five of the six country tariffs. High correlations of utilities (r > 0.7) were found for all country tariffs except for the Netherlands. Moderate to high correlations of converging domain pairs (r from 0.472 to 0.718) were found with few exceptions, such as the Social Functioning–Usual Activities domain pair (max. r = 0.376). For all but the Dutch tariff, the EORTC QLU-C10D produced consistently lower utility values compared to the EQ-5D-3L (x̄ difference from − 0.082 to 0.033). Floor and ceiling effects were consistently lower for the EORTC QLU-C10D (max. 4.67% for utilities). Conclusions The six country tariffs showed good psychometric properties for the EORTC QLU-C10D in lung cancer patients. Criterion and construct validity was established. The QLU-C10D showed superior measurement precision towards the upper and lower end of the scale compared to the EQ-5D-3L, which is important when cost-utility analysis seeks to measure health change across the severity spectrum.

Suggested Citation

  • Micha J. Pilz & Simone Seyringer & Imad Al-Naesan & Madeleine T. King & Andrew Bottomley & Richard Norman & Lisa Schlosser & Tobias Hell & Eva Maria Gamper, 2024. "Cancer-Specific Health Utilities: Evaluation of Core Measurement Properties of the EORTC QLU-C10D in Lung Cancer Patients—Data from Four Multicentre LUX-Lung Trials, Applying Six Country Tariffs," PharmacoEconomics - Open, Springer, vol. 8(4), pages 627-640, July.
    • Handle: RePEc:spr:pharmo:v:8:y:2024:i:4:d:10.1007_s41669-024-00484-9
    DOI: 10.1007/s41669-024-00484-9
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    References listed on IDEAS

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    1. Elizabeth Goodwin & Colin Green, 2016. "A Systematic Review of the Literature on the Development of Condition-Specific Preference-Based Measures of Health," Applied Health Economics and Health Policy, Springer, vol. 14(2), pages 161-183, April.
    2. Dennis A. Revicki & Madeleine T. King & Rosalie Viney & A. Simon Pickard & Rebecca Mercieca-Bebber & James W. Shaw & Fabiola Müller & Richard Norman, 2021. "United States Utility Algorithm for the EORTC QLU-C10D, a Multiattribute Utility Instrument Based on a Cancer-Specific Quality-of-Life Instrument," Medical Decision Making, , vol. 41(4), pages 485-501, May.
    3. Jeff Richardson & Angelo Iezzi & Munir A. Khan & Gang Chen & Aimee Maxwell, 2016. "Measuring the Sensitivity and Construct Validity of 6 Utility Instruments in 7 Disease Areas," Medical Decision Making, , vol. 36(2), pages 147-159, February.
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