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A comparison of measurement properties between EORTC QLU-C10D and FACT-8D in patients with hematological malignances

Author

Listed:
  • Yiyin Cao

    (Harbin Medical University)

  • Haofei Li

    (Harbin Medical University)

  • Ling Jie Cheng

    (National University of Singapore)

  • Madeleine T. King

    (University of Sydney)

  • Georg Kemmler

    (Innsbruck Medical University)

  • David Cella

    (Northwestern University)

  • Hongjuan Yu

    (The First Affiliated Hospital of Harbin Medical University)

  • Weidong Huang

    (Harbin Medical University)

  • Nan Luo

    (National University of Singapore)

Abstract

Objective To perform a comparison of the measurement properties of two cancer-specific Multi-Attribute Utility Instruments (MAUIs), EORTC QLU-C10D and FACT-8D, in Chinese patients with hematologic malignancies (HM). Methods We conducted a longitudinal study on patients with HM in China, using QLU-C10D and FACT-8D at baseline and follow-up (3–4 months from baseline). We assessed: (i) convergent validity using Spearman’s rank correlation test (r) with EQ-5D-5L; (ii) clinical-groups validity by differentiating cancer stages, overall health assessment (OHA), Eastern Cancer Oncology Group (ECOG) performance status, and mental health status. We also examined clinical validity with effect size (ES) and relative efficiency (RE); (iii) responsiveness to changes in patient self-perception using receiver operating characteristics (ROC) curves and area under the curves (AUC); and (iv) agreement using intraclass correlation coefficients (ICC) and visualized with Bland-Altman plot. Results Among the 308 patients with HM at baseline, 131 completed the follow-up survey. Agreement between the two measures was high (ICC = 0.76). Both measures were highly correlated with EQ-5D-5 L and significantly differentiated (p

Suggested Citation

  • Yiyin Cao & Haofei Li & Ling Jie Cheng & Madeleine T. King & Georg Kemmler & David Cella & Hongjuan Yu & Weidong Huang & Nan Luo, 2024. "A comparison of measurement properties between EORTC QLU-C10D and FACT-8D in patients with hematological malignances," Health Economics Review, Springer, vol. 14(1), pages 1-10, December.
  • Handle: RePEc:spr:hecrev:v:14:y:2024:i:1:d:10.1186_s13561-024-00560-0
    DOI: 10.1186/s13561-024-00560-0
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    References listed on IDEAS

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    1. Dennis A. Revicki & Madeleine T. King & Rosalie Viney & A. Simon Pickard & Rebecca Mercieca-Bebber & James W. Shaw & Fabiola Müller & Richard Norman, 2021. "United States Utility Algorithm for the EORTC QLU-C10D, a Multiattribute Utility Instrument Based on a Cancer-Specific Quality-of-Life Instrument," Medical Decision Making, , vol. 41(4), pages 485-501, May.
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