IDEAS home Printed from https://ideas.repec.org/a/spr/pharme/v34y2016i10d10.1007_s40273-016-0409-9.html
   My bibliography  Save this article

A Model-Based Economic Evaluation of Biologic and Non-Biologic Options for the Treatment of Adults with Moderately-to-Severely Active Ulcerative Colitis after the Failure of Conventional Therapy

Author

Listed:
  • Paul Tappenden

    (ScHARR, University of Sheffield)

  • Shijie Ren

    (ScHARR, University of Sheffield)

  • Rachel Archer

    (ScHARR, University of Sheffield)

  • Rebecca Harvey

    (ScHARR, University of Sheffield)

  • Marrissa Martyn-St James

    (ScHARR, University of Sheffield)

  • Hasan Basarir

    (ScHARR, University of Sheffield)

  • John Stevens

    (ScHARR, University of Sheffield)

  • Alan Lobo

    (University of Sheffield)

  • Sami Hoque

    (Barts Health NHS Trust)

Abstract

Background Ulcerative colitis (UC) is the most common form of inflammatory bowel disease in the UK. Medical management aims to induce and maintain remission and to avoid complications and the necessity for surgical intervention. Colectomy removes the source of inflammation but is associated with morbidity and mortality. Newer anti-tumour necrosis factor (TNF)-α therapies may improve medical outcomes, albeit at an increased cost. Objective Our objective was to assess the incremental cost effectiveness of infliximab, adalimumab and golimumab versus conventional therapy and surgery from a National Health Service (NHS) and Personal Social Services (PSS) perspective over a lifetime horizon. Methods A Markov model was developed with health states defined according to whether the patient is alive or dead, current treatments received, history of colectomy and level of disease control. Transition probabilities were derived from network meta-analyses (NMAs) of trials of anti-TNF-α agents in the moderate-to-severe UC population. Health utilities, colectomy rates, surgical complications and resource use estimates were derived from literature. Unit costs were drawn from standard costing sources and literature and were valued at year 2013/2014 values. Results For patients in whom surgery is an option, colectomy is expected to dominate all medical treatment options. For patients in whom colectomy is not an option, infliximab and golimumab are expected to be ruled out due to dominance, whilst the incremental cost-effectiveness ratio (ICER) for adalimumab versus conventional treatment is expected to be approximately £50,278 per quality-adjusted life-year (QALY) gained. Conclusions Based on the NMAs, the ICERs for anti-TNF-α therapy versus conventional treatment or surgery are expected to be at best, in excess of £50,000 per QALY gained. The cost effectiveness of withdrawing biologic therapy upon remission and re-treating relapse is unknown.

Suggested Citation

  • Paul Tappenden & Shijie Ren & Rachel Archer & Rebecca Harvey & Marrissa Martyn-St James & Hasan Basarir & John Stevens & Alan Lobo & Sami Hoque, 2016. "A Model-Based Economic Evaluation of Biologic and Non-Biologic Options for the Treatment of Adults with Moderately-to-Severely Active Ulcerative Colitis after the Failure of Conventional Therapy," PharmacoEconomics, Springer, vol. 34(10), pages 1023-1038, October.
    • Handle: RePEc:spr:pharme:v:34:y:2016:i:10:d:10.1007_s40273-016-0409-9
    DOI: 10.1007/s40273-016-0409-9
    as

    Download full text from publisher

    File URL: http://link.springer.com/10.1007/s40273-016-0409-9
    File Function: Abstract
    Download Restriction: Access to the full text of the articles in this series is restricted.
    File URL: https://libkey.io/10.1007/s40273-016-0409-9?utm_source=ideas
    LibKey link: if access is restricted and if your library uses this service, LibKey will redirect you to where you can use your library subscription to access this item
    ---><---

    As the access to this document is restricted, you may want to search for a different version of it.

    References listed on IDEAS

    as
    1. Unknown, 2014. "Department Publications 2013," Publications Lists 206935, University of Minnesota, Department of Applied Economics.
    Full references (including those not matched with items on IDEAS)

    Citations

    Citations are extracted by the CitEc Project, subscribe to its RSS feed for this item.
    as


    Cited by:

    1. Nadia Pillai & Mark Dusheiko & Bernard Burnand & Valérie Pittet, 2017. "A systematic review of cost-effectiveness studies comparing conventional, biological and surgical interventions for inflammatory bowel disease," PLOS ONE, Public Library of Science, vol. 12(10), pages 1-22, October.
    2. Inigo Bermejo & Paul Tappenden & Ji-Hee Youn, 2017. "Replicating Health Economic Models: Firm Foundations or a House of Cards?," PharmacoEconomics, Springer, vol. 35(11), pages 1113-1121, November.
    3. Inigo Bermejo & Paul Tappenden & Ji-Hee Youn, 2017. "Response to ‘Comment on “Replicating Health Economic Models: Firm Foundations or a House of Cards?”’," PharmacoEconomics, Springer, vol. 35(11), pages 1189-1190, November.
    4. Emma McManus & Tracey Sach, 2017. "Comment on “Replicating Health Economic Models: Firm Foundations or a House of Cards?”," PharmacoEconomics, Springer, vol. 35(11), pages 1187-1188, November.

    Most related items

    These are the items that most often cite the same works as this one and are cited by the same works as this one.
    1. Kim Loader, 2018. "Small- and medium-sized enterprises and public procurement: A review of the UK coalition government's policies and their impact," Environment and Planning C, , vol. 36(1), pages 47-66, February.
    2. Jacopo Arpetti & Antonio Iovanella, 2019. "Towards more effective consumer steering via network analysis," Papers 1903.11469, arXiv.org, revised Nov 2019.
    3. Jeremy Greenwood & Nezih Guner & Guillaume Vandenbroucke, 2017. "Family Economics Writ Large," Journal of Economic Literature, American Economic Association, vol. 55(4), pages 1346-1434, December.
    4. Mai, Nhat Chi, 2022. "Capital Raising and Management of Vietnamese Small and Medium Sized Enterprises after Integrating into Global Economy," OSF Preprints dv68m, Center for Open Science.
    5. Kate Golebiowska, 2016. "Are Peripheral Regions Benefiting from National Policies Aimed at Attracting Skilled Migrants? Case Study of the Northern Territory of Australia," Journal of International Migration and Integration, Springer, vol. 17(3), pages 947-971, August.
    6. Andrew Cleves & Paul Dimmock & Neil Hewitt & Grace Carolan-Rees, 2016. "The TURis System for Transurethral Resection of the Prostate: A NICE Medical Technology Guidance," Applied Health Economics and Health Policy, Springer, vol. 14(3), pages 267-279, June.
    7. Oliveira, Victor & Frazao, Elizabeth, 2015. "The WIC Program: Background, Trends, and Economic Issues, 2015 Edition," Economic Information Bulletin 197543, United States Department of Agriculture, Economic Research Service.
    8. Böhm, Sebastian & Grossmann, Volker & Strulik, Holger, 2021. "R&D-driven medical progress, health care costs, and the future of human longevity," The Journal of the Economics of Ageing, Elsevier, vol. 18(C).
    9. Mehri , N. & Messkoub, M. & Kunkel, S., 2019. "Trends, determinants and the implications of population aging in Iran," ISS Working Papers - General Series 646, International Institute of Social Studies of Erasmus University Rotterdam (ISS), The Hague.
    10. Mahdi Gharaibeh & Ali McBride & David S. Alberts & Brian Erstad & Marion Slack & Nimer Alsaid & J. Lyle Bootman & Ivo Abraham, 2018. "Economic Evaluation for the UK of Systemic Chemotherapies as First-Line Treatment of Metastatic Pancreatic Cancer," PharmacoEconomics, Springer, vol. 36(11), pages 1333-1343, November.
    11. Paul Cheshire & Stephen Gibbons & Jemma Mouland, 2017. "Social Tenants' Health: Evaluating the Effectiveness of Landlord Interventions," SERC Discussion Papers 0219, Centre for Economic Performance, LSE.
    12. Robert Koulish, 2016. "Using Risk to Assess the Legal Violence of Mandatory Detention," Laws, MDPI, vol. 5(3), pages 1-20, July.
    13. Liao, Kenneth & Pouliot, Sebastien, 2015. "Econometric Analysis of Motorists’ Preference for Ethanol in Motor Fuel," 2015 AAEA & WAEA Joint Annual Meeting, July 26-28, San Francisco, California 205473, Agricultural and Applied Economics Association.
    14. Karen S Palmer & Thomas Agoritsas & Danielle Martin & Taryn Scott & Sohail M Mulla & Ashley P Miller & Arnav Agarwal & Andrew Bresnahan & Afeez Abiola Hazzan & Rebecca A Jeffery & Arnaud Merglen & Ahm, 2014. "Activity-Based Funding of Hospitals and Its Impact on Mortality, Readmission, Discharge Destination, Severity of Illness, and Volume of Care: A Systematic Review and Meta-Analysis," PLOS ONE, Public Library of Science, vol. 9(10), pages 1-1, October.
    15. Vuyokazi Magungxu & Philani Moyo, 2014. "Prisoner-warder ratio parity in a South African Correctional Centre: Repercussions on prison work environment and correctional security personnel," Journal of Economics and Behavioral Studies, AMH International, vol. 6(5), pages 411-417.
    16. Molina, Oswaldo & Saldarriaga, Victor, 2017. "The perils of climate change: In utero exposure to temperature variability and birth outcomes in the Andean region," Economics & Human Biology, Elsevier, vol. 24(C), pages 111-124.
    17. Michael Freeman & Nicos Savva & Stefan Scholtes, 2021. "Economies of Scale and Scope in Hospitals: An Empirical Study of Volume Spillovers," Management Science, INFORMS, vol. 67(2), pages 673-697, February.
    18. Fiscalis Tax Gap Project Group, 2016. "The concept of tax gaps - Report on VAT Gap Estimations," Taxation Studies 0065, Directorate General Taxation and Customs Union, European Commission.
    19. Catrin Treharne & Frank Liu & Murat Arici & Lydia Crowe & Usman Farooqui, 2014. "Peritoneal Dialysis and In-Centre Haemodialysis: A Cost-Utility Analysis from a UK Payer Perspective," Applied Health Economics and Health Policy, Springer, vol. 12(4), pages 409-420, August.
    20. Mothemba Mokoena & Merwe Oberholzer, 2017. "Analyzing Biographical Differences on Employees' Perception of Safety Control Measures with Special Emphasis on the Cost Thereof at a Colliery," Journal of Economics and Behavioral Studies, AMH International, vol. 8(6), pages 68-81.

    More about this item

    Statistics

    Access and download statistics

    Corrections

    All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:spr:pharme:v:34:y:2016:i:10:d:10.1007_s40273-016-0409-9. See general information about how to correct material in RePEc.

    If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

    If CitEc recognized a bibliographic reference but did not link an item in RePEc to it, you can help with this form .

    If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.

    For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: Sonal Shukla or Springer Nature Abstracting and Indexing (email available below). General contact details of provider: http://www.springer.com .

    Please note that corrections may take a couple of weeks to filter through the various RePEc services.

    IDEAS is a RePEc service. RePEc uses bibliographic data supplied by the respective publishers.