IDEAS home Printed from https://ideas.repec.org/a/spr/drugsa/v46y2023i5d10.1007_s40264-023-01283-7.html
   My bibliography  Save this article

Drug–Drug Interactions and the Risk of Emergency Hospitalizations: A Nationwide Population-Based Study

Author

Listed:
  • Louis Létinier

    (University of Bordeaux
    Université de Bordeaux)

  • Julien Bezin

    (University of Bordeaux
    Université de Bordeaux)

  • Ana Jarne

    (University of Bordeaux)

  • Antoine Pariente

    (Université de Bordeaux)

Abstract

Background Several studies suggest a significant risk of hospitalization because of drug–drug interactions in the general population. However, to our knowledge, this risk has never been measured precisely in a large population. Objective We aimed to estimate the risk of emergency hospitalization associated with exposure to the contraindicated concomitant use of interacting drugs in the general population. Methods A self-controlled case-series analysis was carried out on a cohort of 150,000 subjects randomly selected from the French national health insurance database, between 01/01/2016 and 31/12/2016. Exposure to the contraindicated concomitant use of interacting drugs was defined as the overlapping period of dispensings of drugs contraindicated because of clinically meaningful drug–drug interactions. The main outcome, incidence rate ratios, comparing the incidence rate of emergency hospitalizations during each category of exposure time periods with that during the reference period, was estimated using the conditional Poisson regression model. Results Over the study period, 967 subjects were exposed to at least one contraindicated concomitant use of interacting drug and 177 had been exposed and presented at least one emergency hospitalization. Compared to the unexposed follow-up time, the risk of emergency hospitalization increased during exposure to contraindicated concomitant use of interacting drug periods (incidence rate ratio: 2.41; 95% confidence interval 1.55–3.76). This could translate into 7200 (4500–8900) potentially preventable emergency hospitalizations yearly in France. Conclusions We evidenced an almost 2.5-fold increase in the risk of emergency hospitalizations during periods of exposure to contraindicated concomitant use of interacting drugs, with a potential public health impact exceeding 7000 preventable hospitalizations yearly in France. These results confirm the need to reinforce training in prescription practices and tools for prevention concerning contraindicated concomitant use of interacting drugs. These would especially concern drugs involved in an increase in long QT syndrome when associated such as citalopram, and highly prescribed drugs with a risk of overdose if co-prescribed with cytochrome P450 inhibitors, such as antigout and lipid-lowering drugs.

Suggested Citation

  • Louis Létinier & Julien Bezin & Ana Jarne & Antoine Pariente, 2023. "Drug–Drug Interactions and the Risk of Emergency Hospitalizations: A Nationwide Population-Based Study," Drug Safety, Springer, vol. 46(5), pages 449-456, May.
  • Handle: RePEc:spr:drugsa:v:46:y:2023:i:5:d:10.1007_s40264-023-01283-7
    DOI: 10.1007/s40264-023-01283-7
    as

    Download full text from publisher

    File URL: http://link.springer.com/10.1007/s40264-023-01283-7
    File Function: Abstract
    Download Restriction: Access to the full text of the articles in this series is restricted.

    File URL: https://libkey.io/10.1007/s40264-023-01283-7?utm_source=ideas
    LibKey link: if access is restricted and if your library uses this service, LibKey will redirect you to where you can use your library subscription to access this item
    ---><---

    As the access to this document is restricted, you may want to search for a different version of it.

    References listed on IDEAS

    as
    1. Rockhill, B. & Newman, B. & Weinberg, C., 1998. "Use and misuse of population attributable fractions," American Journal of Public Health, American Public Health Association, vol. 88(1), pages 15-19.
    Full references (including those not matched with items on IDEAS)

    Most related items

    These are the items that most often cite the same works as this one and are cited by the same works as this one.
    1. Michael G Baker & Jason Gurney & Jane Oliver & Nicole J Moreland & Deborah A Williamson & Nevil Pierse & Nigel Wilson & Tony R Merriman & Teuila Percival & Colleen Murray & Catherine Jackson & Richard, 2019. "Risk Factors for Acute Rheumatic Fever: Literature Review and Protocol for a Case-Control Study in New Zealand," IJERPH, MDPI, vol. 16(22), pages 1-39, November.
    2. Corsi, Daniel J. & Mejía-Guevara, Iván & Subramanian, S.V., 2016. "Risk factors for chronic undernutrition among children in India: Estimating relative importance, population attributable risk and fractions," Social Science & Medicine, Elsevier, vol. 157(C), pages 165-185.
    3. Eva Deuchert, 2011. "The Virgin HIV Puzzle: Can Misreporting Account for the High Proportion of HIV Cases in Self-reported Virgins?," Journal of African Economies, Centre for the Study of African Economies, vol. 20(1), pages 60-89, January.
    4. Kenneth Anujuo & Karien Stronks & Marieke B. Snijder & Anja Lok & Girardin Jean-Louis & Charles Agyemang, 2021. "Association between Depressed Mood and Sleep Duration among Various Ethnic Groups—The Helius Study," IJERPH, MDPI, vol. 18(13), pages 1-10, July.
    5. Osita K. Ezeh & Felix A. Ogbo & Anastasia O. Odumegwu & Gladys H. Oforkansi & Uchechukwu D. Abada & Piwuna C. Goson & Tanko Ishaya & Kingsley E. Agho, 2021. "Under-5 Mortality and Its Associated Factors in Northern Nigeria: Evidence from 22,455 Singleton Live Births (2013–2018)," IJERPH, MDPI, vol. 18(18), pages 1-16, September.
    6. Ana Isabel Ribeiro & Elias Teixeira Krainski & Marilia Sá Carvalho & Guy Launoy & Carole Pornet & Maria de Fátima Pina, 2018. "Does community deprivation determine longevity after the age of 75? A cross-national analysis," International Journal of Public Health, Springer;Swiss School of Public Health (SSPH+), vol. 63(4), pages 469-479, May.
    7. Jessica Ho & Irma Elo, 2013. "The Contribution of Smoking to Black-White Differences in U.S. Mortality," Demography, Springer;Population Association of America (PAA), vol. 50(2), pages 545-568, April.
    8. Allison Larg & John Moss, 2011. "Cost-of-Illness Studies," PharmacoEconomics, Springer, vol. 29(8), pages 653-671, August.
    9. Anu Molarius & Alexandra Metsini, 2021. "Domestic Work, Self-Reported Diagnosed Depression and Related Costs among Women and Men—Results from a Population-Based Study in Sweden," IJERPH, MDPI, vol. 18(18), pages 1-11, September.
    10. Weldegebriel, Habtu T. & Gunn, George J. & Stott, Alistair W., 2008. "Winners and losers from Johne’s disease eradication from the Scottish dairy herd: a Markov-Chain simulation," 82nd Annual Conference, March 31 - April 2, 2008, Royal Agricultural College, Cirencester, UK 36872, Agricultural Economics Society.
    11. Pierre Philip & Jean-Arthur Micoulaud-Franchi & Emmanuel Lagarde & Jacques Taillard & Annick Canel & Patricia Sagaspe & Stéphanie Bioulac, 2015. "Attention Deficit Hyperactivity Disorder Symptoms, Sleepiness and Accidental Risk in 36140 Regularly Registered Highway Drivers," PLOS ONE, Public Library of Science, vol. 10(9), pages 1-14, September.
    12. Jing Hou & Dachao Lv & Yuexia Sun & Pan Wang & Qingnan Zhang & Jan Sundell, 2020. "Children’s Respiratory Infections in Tianjin Area, China: Associations with Home Environments and Lifestyles," IJERPH, MDPI, vol. 17(11), pages 1-13, June.
    13. Huanbi Yue & Chunyang He & Qingxu Huang & Da Zhang & Peijun Shi & Enayat A. Moallemi & Fangjin Xu & Yang Yang & Xin Qi & Qun Ma & Brett A. Bryan, 2024. "Substantially reducing global PM2.5-related deaths under SDG3.9 requires better air pollution control and healthcare," Nature Communications, Nature, vol. 15(1), pages 1-13, December.
    14. Hoffmann, Rasmus & Kröger, Hannes & Tarkiainen, Lasse & Martikainen, Pekka, 2019. "Dimensions of Social Stratification and Their Relation to Mortality: A Comparison Across Gender and Life Course Periods in Finland," EconStor Open Access Articles and Book Chapters, ZBW - Leibniz Information Centre for Economics, vol. 145(1), pages 349-365.
    15. Laura Rosen, 2013. "An Intuitive Approach to Understanding the Attributable Fraction of Disease Due to a Risk Factor: The Case of Smoking," IJERPH, MDPI, vol. 10(7), pages 1-12, July.
    16. Mona Elbarbary & Trenton Honda & Geoffrey Morgan & Yuming Guo & Yanfei Guo & Paul Kowal & Joel Negin, 2020. "Ambient Air Pollution Exposure Association with Anaemia Prevalence and Haemoglobin Levels in Chinese Older Adults," IJERPH, MDPI, vol. 17(9), pages 1-15, May.
    17. Mary C. White & Marion (Mhel) H. E. Kavanaugh-Lynch & Shauntay Davis-Patterson & Nancy Buermeyer, 2020. "An Expanded Agenda for the Primary Prevention of Breast Cancer: Charting a Course for the Future," IJERPH, MDPI, vol. 17(3), pages 1-11, January.
    18. Zhi Cao & Jiahao Min & Han Chen & Yabing Hou & Hongxi Yang & Keyi Si & Chenjie Xu, 2024. "Accelerometer-derived physical activity and mortality in individuals with type 2 diabetes," Nature Communications, Nature, vol. 15(1), pages 1-11, December.
    19. Jo-An Atkinson & Dylan Knowles & John Wiggers & Michael Livingston & Robin Room & Ante Prodan & Geoff McDonnell & Eloise O’Donnell & Sandra Jones & Paul S. Haber & David Muscatello & Nadine Ezard & Ng, 2018. "Harnessing advances in computer simulation to inform policy and planning to reduce alcohol-related harms," International Journal of Public Health, Springer;Swiss School of Public Health (SSPH+), vol. 63(4), pages 537-546, May.
    20. Rasmus Hoffmann & Hannes Kröger & Lasse Tarkiainen & Pekka Martikainen, 2019. "Dimensions of Social Stratification and Their Relation to Mortality: A Comparison Across Gender and Life Course Periods in Finland," Social Indicators Research: An International and Interdisciplinary Journal for Quality-of-Life Measurement, Springer, vol. 145(1), pages 349-365, August.

    More about this item

    Statistics

    Access and download statistics

    Corrections

    All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:spr:drugsa:v:46:y:2023:i:5:d:10.1007_s40264-023-01283-7. See general information about how to correct material in RePEc.

    If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

    If CitEc recognized a bibliographic reference but did not link an item in RePEc to it, you can help with this form .

    If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.

    For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: Sonal Shukla or Springer Nature Abstracting and Indexing (email available below). General contact details of provider: http://www.springer.com/economics/journal/40264 .

    Please note that corrections may take a couple of weeks to filter through the various RePEc services.

    IDEAS is a RePEc service. RePEc uses bibliographic data supplied by the respective publishers.