IDEAS home Printed from https://ideas.repec.org/a/sae/medema/v26y2006i1p38-47.html
   My bibliography  Save this article

Reassessing the Cost-Effectiveness of Meningococcal Serogroup C Conjugate (MCC) Vaccines Using a Transmission Dynamic Model

Author

Listed:
  • Caroline L. Trotter
  • W. John Edmunds

    (Modelling and Economics Unit, Centre for Infections, Health Protection Agency, 61 Colindale Avenue, London, NW95EQ, UK; phone: +44 20 8327 7410; fax: +44 20 8200 7868; john.edmunds@hpa.org.uk)

Abstract

Background. The meningococcal serogroup C conjugate (MCC) vaccination program has successfully reduced morbidity and mortality from serogroup C disease in England and Wales, owing to high short-term vaccine effectiveness and substantial herd immunity. The latter effect was not accounted for in the previous economic analysis of the MCC program. Methods. The authors applied a transmission dynamicmodel, which accounts for herd immunity, to reevaluate the cost-effectiveness of MCC vaccination. The direct and indirect benefits of the MCC vaccine strategy implemented in England and Wales were compared. The cost-effectiveness of alternative MCC vaccine strategies, including future changes to the current schedule, were evaluated. Results. The authors found that including herd immunity improved the average cost-effectiveness ratio in all cases, although the extent depended on the vaccine strategy considered. Incremental analysis showed that those strategies that offered 1 dose early in the 2nd year of life dominated strategies that offered 3 doses of vaccine in infancy and that catch-up vaccination up to the age of 18 years was also highly attractive. Furthermore, the authors analyzed the effect of future changes to the routine vaccine schedule and predicted that shifting the age at routine vaccination from 2, 3, and 4 months (3 doses) to 12 months (1 dose) resulted in a net gain in the total number of cases prevented with only a few extra cases occurring in children under 1 year of age. This program dominated the current strategy. Conclusions. Models that do not include the indirect effects of vaccination will underestimate the impact of MCC vaccination andmay lead to distorted decision making.

Suggested Citation

  • Caroline L. Trotter & W. John Edmunds, 2006. "Reassessing the Cost-Effectiveness of Meningococcal Serogroup C Conjugate (MCC) Vaccines Using a Transmission Dynamic Model," Medical Decision Making, , vol. 26(1), pages 38-47, January.
    • Handle: RePEc:sae:medema:v:26:y:2006:i:1:p:38-47
    DOI: 10.1177/0272989X05284109
    as

    Download full text from publisher

    File URL: https://journals.sagepub.com/doi/10.1177/0272989X05284109
    Download Restriction: no
    File URL: https://libkey.io/10.1177/0272989X05284109?utm_source=ideas
    LibKey link: if access is restricted and if your library uses this service, LibKey will redirect you to where you can use your library subscription to access this item
    ---><---

    References listed on IDEAS

    as
    1. M. Brisson & W. J. Edmunds, 2003. "Economic Evaluation of Vaccination Programs: The Impact of Herd-Immunity," Medical Decision Making, , vol. 23(1), pages 76-82, January.
    Full references (including those not matched with items on IDEAS)

    Citations

    Citations are extracted by the CitEc Project, subscribe to its RSS feed for this item.
    as


    Cited by:

    1. Marisa Holubar & Maria Christina Stavroulakis & Yvonne Maldonado & John P A Ioannidis & Despina Contopoulos-Ioannidis, 2017. "Impact of vaccine herd-protection effects in cost-effectiveness analyses of childhood vaccinations. A quantitative comparative analysis," PLOS ONE, Public Library of Science, vol. 12(3), pages 1-22, March.
    2. Gary M. Ginsberg & Colin Block & Chen Stein-Zamir, 2016. "Cost-utility analysis of a nationwide vaccination programme against serogroup B meningococcal disease in Israel," International Journal of Public Health, Springer;Swiss School of Public Health (SSPH+), vol. 61(6), pages 683-692, July.
    3. Laurent Coudeville & Annelies Van Rie & Denis Getsios & J Jaime Caro & Pascal Crépey & Van Hung Nguyen, 2009. "Adult Vaccination Strategies for the Control of Pertussis in the United States: An Economic Evaluation Including the Dynamic Population Effects," PLOS ONE, Public Library of Science, vol. 4(7), pages 1-9, July.

    Most related items

    These are the items that most often cite the same works as this one and are cited by the same works as this one.
    1. Wang, Jianwei & Xu, Wenshu & Chen, Wei & Yu, Fengyuan & He, Jialu, 2021. "Information sharing can suppress the spread of epidemics: Voluntary vaccination game on two-layer networks," Physica A: Statistical Mechanics and its Applications, Elsevier, vol. 583(C).
    2. Arnold Kamis & Yuji Zhang & Tamara Kamis, 2017. "A Multiyear Model of Influenza Vaccination in the United States," IJERPH, MDPI, vol. 14(8), pages 1-14, July.
    3. Laurent Coudeville & Annelies Van Rie & Denis Getsios & J Jaime Caro & Pascal Crépey & Van Hung Nguyen, 2009. "Adult Vaccination Strategies for the Control of Pertussis in the United States: An Economic Evaluation Including the Dynamic Population Effects," PLOS ONE, Public Library of Science, vol. 4(7), pages 1-9, July.
    4. Greg Plosker, 2011. "Rotavirus Vaccine RIX4414 (Rotarix™)," PharmacoEconomics, Springer, vol. 29(11), pages 989-1009, November.
    5. Choudhury, Agnitra Roy & Polachek, Solomon, 2019. "The Impact of Paid Family Leave on the Timing of Infant Vaccinations," IZA Discussion Papers 12483, Institute of Labor Economics (IZA).
    6. Wang, Qingqing & Du, Chunpeng & Geng, Yini & Shi, Lei, 2020. "Historical payoff can not overcome the vaccination dilemma on Barabási–Albert scale-free networks," Chaos, Solitons & Fractals, Elsevier, vol. 130(C).
    7. Benyun Shi & Guangliang Liu & Hongjun Qiu & Yu-Wang Chen & Shaoliang Peng, 2019. "Voluntary Vaccination through Perceiving Epidemic Severity in Social Networks," Complexity, Hindawi, vol. 2019, pages 1-13, February.
    8. Anna K. Lugnér & Sido D. Mylius & Jacco Wallinga, 2010. "Dynamic versus static models in cost‐effectiveness analyses of anti‐viral drug therapy to mitigate an influenza pandemic," Health Economics, John Wiley & Sons, Ltd., vol. 19(5), pages 518-531, May.
    9. Radboud J. Duintjer Tebbens & Kimberly M. Thompson, 2009. "Priority Shifting and the Dynamics of Managing Eradicable Infectious Diseases," Management Science, INFORMS, vol. 55(4), pages 650-663, April.
    10. Mario Songane, 2018. "Challenges for nationwide vaccine delivery in African countries," International Journal of Health Economics and Management, Springer, vol. 18(2), pages 197-219, June.
    11. Sang-Man Kim & Arben Asllani, 2013. "Using simulation to establish appropriate vaccination rates and copayment policies from a cost perspective," Service Business, Springer;Pan-Pacific Business Association, vol. 7(3), pages 437-457, September.
    12. Andrea Anonychuk & Andrea Tricco & Chris Bauch & Ba’ Pham & Vladimir Gilca & Bernard Duval & Ava John-Baptiste & Gloria Woo & Murray Krahn, 2008. "Cost-Effectiveness Analyses of Hepatitis A Vaccine," PharmacoEconomics, Springer, vol. 26(1), pages 17-32, January.
    13. Sun-Young Kim & Sue Goldie, 2008. "Cost-Effectiveness Analyses of Vaccination Programmes," PharmacoEconomics, Springer, vol. 26(3), pages 191-215, March.
    14. Iwamura, Yoshiro & Tanimoto, Jun, 2018. "Realistic decision-making processes in a vaccination game," Physica A: Statistical Mechanics and its Applications, Elsevier, vol. 494(C), pages 236-241.
    15. Rachel Elliott & Helen Weatherly & Neil Hawkins & Gillian Cranny & Duncan Chambers & Lindsey Myers & Alison Eastwood & Mark Sculpher, 2010. "An economic model for the prevention of MRSA infections after surgery: non-glycopeptide or glycopeptide antibiotic prophylaxis?," The European Journal of Health Economics, Springer;Deutsche Gesellschaft für Gesundheitsökonomie (DGGÖ), vol. 11(1), pages 57-66, February.

    Corrections

    All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:sae:medema:v:26:y:2006:i:1:p:38-47. See general information about how to correct material in RePEc.

    If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

    If CitEc recognized a bibliographic reference but did not link an item in RePEc to it, you can help with this form .

    If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.

    For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: SAGE Publications (email available below). General contact details of provider: .

    Please note that corrections may take a couple of weeks to filter through the various RePEc services.

    IDEAS is a RePEc service. RePEc uses bibliographic data supplied by the respective publishers.