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Adult Vaccination Strategies for the Control of Pertussis in the United States: An Economic Evaluation Including the Dynamic Population Effects

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  • Laurent Coudeville
  • Annelies Van Rie
  • Denis Getsios
  • J Jaime Caro
  • Pascal Crépey
  • Van Hung Nguyen

Abstract

Background: Prior economic evaluations of adult and adolescent vaccination strategies against pertussis have reached disparate conclusions. Using static approaches only, previous studies failed to analytically include the indirect benefits derived from herd immunity as well as the impact of vaccination on the evolution of disease incidence over time. Methods: We assessed the impact of different pertussis vaccination strategies using a dynamic compartmental model able to consider pertussis transmission. We then combined the results with economic data to estimate the relative cost-effectiveness of pertussis immunization strategies for adolescents and adults in the US. The analysis compares combinations of programs targeting adolescents, parents of newborns (i.e. cocoon strategy), or adults of various ages. Results: In the absence of adolescent or adult vaccination, pertussis incidence among adults is predicted to more than double in 20 years. Implementing an adult program in addition to childhood and adolescent vaccination either based on 1) a cocoon strategy and a single booster dose or 2) a decennial routine vaccination would maintain a low level of pertussis incidence in the long run for all age groups (respectively 30 and 20 cases per 100,000 person years). These strategies would also result in significant reductions of pertussis costs (between −77% and −80% including additional vaccination costs). The cocoon strategy complemented by a single booster dose is the most cost-effective one, whereas the decennial adult vaccination is slightly more effective in the long run. Conclusions: By providing a high level of disease control, the implementation of an adult vaccination program against pertussis appears to be highly cost-effective and often cost-saving.

Suggested Citation

  • Laurent Coudeville & Annelies Van Rie & Denis Getsios & J Jaime Caro & Pascal Crépey & Van Hung Nguyen, 2009. "Adult Vaccination Strategies for the Control of Pertussis in the United States: An Economic Evaluation Including the Dynamic Population Effects," PLOS ONE, Public Library of Science, vol. 4(7), pages 1-9, July.
    • Handle: RePEc:plo:pone00:0006284
    DOI: 10.1371/journal.pone.0006284
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    References listed on IDEAS

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    1. Drummond, Michael F. & Sculpher, Mark J. & Torrance, George W. & O'Brien, Bernie J. & Stoddart, Greg L., 2005. "Methods for the Economic Evaluation of Health Care Programmes," OUP Catalogue, Oxford University Press, edition 3, number 9780198529453.
    2. M. Brisson & W. J. Edmunds, 2006. "Impact of Model, Methodological, and Parameter Uncertainty in the Economic Analysis of Vaccination Programs," Medical Decision Making, , vol. 26(5), pages 434-446, September.
    3. Caroline L. Trotter & W. John Edmunds, 2006. "Reassessing the Cost-Effectiveness of Meningococcal Serogroup C Conjugate (MCC) Vaccines Using a Transmission Dynamic Model," Medical Decision Making, , vol. 26(1), pages 38-47, January.
    4. M. Brisson & W. J. Edmunds, 2003. "Economic Evaluation of Vaccination Programs: The Impact of Herd-Immunity," Medical Decision Making, , vol. 23(1), pages 76-82, January.
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    1. Rivero-Santana, Amado & Cuéllar-Pompa, Leticia & Sánchez-Gómez, Luis M. & Perestelo-Pérez, Lilisbeth & Serrano-Aguilar, Pedro, 2014. "Effectiveness and cost-effectiveness of different immunization strategies against whooping cough to reduce child morbidity and mortality," Health Policy, Elsevier, vol. 115(1), pages 82-91.
    2. Giovanni Gabutti & Maria Cristina Rota, 2012. "Pertussis: A Review of Disease Epidemiology Worldwide and in Italy," IJERPH, MDPI, vol. 9(12), pages 1-13, December.
    3. Sun, Ruoyan, 2013. "Kinetics of jobs in multi-link cities with migration-driven aggregation process," Economic Modelling, Elsevier, vol. 30(C), pages 36-41.
    4. Caroline Orset, 2018. "People’s perception and cost-effectiveness of home confinement during an influenza pandemic: evidence from the French case," The European Journal of Health Economics, Springer;Deutsche Gesellschaft für Gesundheitsökonomie (DGGÖ), vol. 19(9), pages 1335-1350, December.

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