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Prediction of suicidal ideation and attempt in 9 and 10 year-old children using transdiagnostic risk features

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Listed:
  • Gareth Harman
  • Dakota Kliamovich
  • Angelica M Morales
  • Sydney Gilbert
  • Deanna M Barch
  • Michael A Mooney
  • Sarah W Feldstein Ewing
  • Damien A Fair
  • Bonnie J Nagel

Abstract

The objective of the current study was to build predictive models for suicidal ideation in a sample of children aged 9–10 using features previously implicated in risk among older adolescent and adult populations. This case-control analysis utilized baseline data from the Adolescent Brain and Cognitive Development (ABCD) Study, collected from 21 research sites across the United States (N = 11,369). Several regression and ensemble learning models were compared on their ability to classify individuals with suicidal ideation and/or attempt from healthy controls, as assessed by the Kiddie Schedule for Affective Disorders and Schizophrenia–Present and Lifetime Version. When comparing control participants (mean age: 9.92±0.62 years; 4944 girls [49%]) to participants with suicidal ideation (mean age: 9.89±0.63 years; 451 girls [40%]), both logistic regression with feature selection and elastic net without feature selection predicted suicidal ideation with an AUC of 0.70 (CI 95%: 0.70–0.71). The random forest with feature selection trained to predict suicidal ideation predicted a holdout set of children with a history of suicidal ideation and attempt (mean age: 9.96±0.62 years; 79 girls [41%]) from controls with an AUC of 0.77 (CI 95%: 0.76–0.77). Important features from these models included feelings of loneliness and worthlessness, impulsivity, prodromal psychosis symptoms, and behavioral problems. This investigation provided an unprecedented opportunity to identify suicide risk in youth. The use of machine learning to examine a large number of predictors spanning a variety of domains provides novel insight into transdiagnostic factors important for risk classification.

Suggested Citation

  • Gareth Harman & Dakota Kliamovich & Angelica M Morales & Sydney Gilbert & Deanna M Barch & Michael A Mooney & Sarah W Feldstein Ewing & Damien A Fair & Bonnie J Nagel, 2021. "Prediction of suicidal ideation and attempt in 9 and 10 year-old children using transdiagnostic risk features," PLOS ONE, Public Library of Science, vol. 16(5), pages 1-14, May.
  • Handle: RePEc:plo:pone00:0252114
    DOI: 10.1371/journal.pone.0252114
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    References listed on IDEAS

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    1. Friedman, Jerome H. & Hastie, Trevor & Tibshirani, Rob, 2010. "Regularization Paths for Generalized Linear Models via Coordinate Descent," Journal of Statistical Software, Foundation for Open Access Statistics, vol. 33(i01).
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    1. Emma Ashworth & Ian Jarman & Philippa McCabe & Molly McCarthy & Serena Provazza & Vivienne Crosbie & Zara Quigg & Pooja Saini, 2023. "Suicidal Crisis among Children and Young People: Associations with Adverse Childhood Experiences and Socio-Demographic Factors," IJERPH, MDPI, vol. 20(2), pages 1-13, January.

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