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DPP-4 inhibitors may improve the mortality of coronavirus disease 2019: A meta-analysis

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  • Yan Yang
  • Zixin Cai
  • Jingjing Zhang

Abstract

Aims: DPP-4 inhibitors are predicted to exert a protective effect on the progression of coronavirus disease 2019 (COVID-19). We conducted this meta-analysis to investigate this hypothesis. Methods: Four databases, namely, PubMed, Web of Science, EMBASE and the Cochrane Library, were used to identify studies on DPP-4 and COVID-19. The outcome indicators were the mortality of COVID-19. Funnel plots, Begg’s tests and Egger’s tests were used to assess publication bias. Results: Four articles were included with a total of 1933 patients with COVID-19 and type 2 diabetes. The use of DPP-4 inhibitors was negatively associated with the risk of mortality (odds ratio (OR) = 0.58 95% confidence interval (CI), 0.34–0.99). Conclusions: DPP-4 inhibitors may improve the mortality of patients with COVID-19 and type 2 diabetes. As few relevant studies are available, more large-scale studies need to be performed.

Suggested Citation

  • Yan Yang & Zixin Cai & Jingjing Zhang, 2021. "DPP-4 inhibitors may improve the mortality of coronavirus disease 2019: A meta-analysis," PLOS ONE, Public Library of Science, vol. 16(5), pages 1-10, May.
    • Handle: RePEc:plo:pone00:0251916
    DOI: 10.1371/journal.pone.0251916
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    1. V. Stalin Raj & Huihui Mou & Saskia L. Smits & Dick H. W. Dekkers & Marcel A. Müller & Ronald Dijkman & Doreen Muth & Jeroen A. A. Demmers & Ali Zaki & Ron A. M. Fouchier & Volker Thiel & Christian Dr, 2013. "Dipeptidyl peptidase 4 is a functional receptor for the emerging human coronavirus-EMC," Nature, Nature, vol. 495(7440), pages 251-254, March.
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