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Cost-effectiveness of psychological treatments for post-traumatic stress disorder in adults

Author

Listed:
  • Ifigeneia Mavranezouli
  • Odette Megnin-Viggars
  • Nick Grey
  • Gita Bhutani
  • Jonathan Leach
  • Caitlin Daly
  • Sofia Dias
  • Nicky J Welton
  • Cornelius Katona
  • Sharif El-Leithy
  • Neil Greenberg
  • Sarah Stockton
  • Stephen Pilling

Abstract

Background: Post-traumatic stress disorder (PTSD) is a severe and disabling condition that may lead to functional impairment and reduced productivity. Psychological interventions have been shown to be effective in its management. The objective of this study was to assess the cost-effectiveness of a range of interventions for adults with PTSD. Methods: A decision-analytic model was constructed to compare costs and quality-adjusted life-years (QALYs) of 10 interventions and no treatment for adults with PTSD, from the perspective of the National Health Service and personal social services in England. Effectiveness data were derived from a systematic review and network meta-analysis. Other model input parameters were based on published sources, supplemented by expert opinion. Results: Eye movement desensitisation and reprocessing (EMDR) appeared to be the most cost-effective intervention for adults with PTSD (with a probability of 0.34 amongst the 11 evaluated options at a cost-effectiveness threshold of £20,000/QALY), followed by combined somatic/cognitive therapies, self-help with support, psychoeducation, selective serotonin reuptake inhibitors (SSRIs), trauma-focused cognitive behavioural therapy (TF-CBT), self-help without support, non-TF-CBT and combined TF-CBT/SSRIs. Counselling appeared to be less cost-effective than no treatment. TF-CBT had the largest evidence base. Conclusions: A number of interventions appear to be cost-effective for the management of PTSD in adults. EMDR appears to be the most cost-effective amongst them. TF-CBT has the largest evidence base. There remains a need for well-conducted studies that examine the long-term clinical and cost-effectiveness of a range of treatments for adults with PTSD.

Suggested Citation

  • Ifigeneia Mavranezouli & Odette Megnin-Viggars & Nick Grey & Gita Bhutani & Jonathan Leach & Caitlin Daly & Sofia Dias & Nicky J Welton & Cornelius Katona & Sharif El-Leithy & Neil Greenberg & Sarah S, 2020. "Cost-effectiveness of psychological treatments for post-traumatic stress disorder in adults," PLOS ONE, Public Library of Science, vol. 15(4), pages 1-22, April.
    • Handle: RePEc:plo:pone00:0232245
    DOI: 10.1371/journal.pone.0232245
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    References listed on IDEAS

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    1. Walters, SJ & Brazier, JE, 2002. "Sample sizes for the SF-6D preference based measure of health from the SF-36: a practical guide," MPRA Paper 29742, University Library of Munich, Germany.
    2. Briggs, Andrew & Sculpher, Mark & Claxton, Karl, 2006. "Decision Modelling for Health Economic Evaluation," OUP Catalogue, Oxford University Press, number 9780198526629.
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    1. Amedu, Amos Nnaemeka, 2023. "Assessment of Psychological Treatments and Its Affordability Among Students with Post-Traumatic Stress Disorder: A Scoping Review," International Journal of Home Economics, Hospitality and Allied Research, Department of Home Economics & Hospitality Management Education, University of Nigeria, Nsukka, vol. 2(2), pages 248-264, December.

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