IDEAS home Printed from https://ideas.repec.org/a/plo/pone00/0227281.html
   My bibliography  Save this article

Spectral characteristics of urine from patients with end-stage kidney disease analyzed using Raman Chemometric Urinalysis (Rametrix)

Author

Listed:
  • Ryan S Senger
  • Meaghan Sullivan
  • Austin Gouldin
  • Stephanie Lundgren
  • Kristen Merrifield
  • Caitlin Steen
  • Emily Baker
  • Tommy Vu
  • Ben Agnor
  • Gabrielle Martinez
  • Hana Coogan
  • William Carswell
  • Varun Kavuru
  • Lampros Karageorge
  • Devasmita Dev
  • Pang Du
  • Allan Sklar
  • James Pirkle Jr
  • Susan Guelich
  • Giuseppe Orlando
  • John L Robertson

Abstract

Raman Chemometric Urinalysis (RametrixTM) was used to discern differences in Raman spectra from (i) 362 urine specimens from patients receiving peritoneal dialysis (PD) therapy for end-stage kidney disease (ESKD), (ii) 395 spent dialysate specimens from those PD therapies, and (iii) 235 urine specimens from healthy human volunteers. RametrixTM analysis includes spectral processing (e.g., truncation, baselining, and vector normalization); principal component analysis (PCA); statistical analyses (ANOVA and pairwise comparisons); discriminant analysis of principal components (DAPC); and testing DAPC models using a leave-one-out build/test validation procedure. Results showed distinct and statistically significant differences between the three types of specimens mentioned above. Further, when introducing “unknown” specimens, RametrixTM was able to identify the type of specimen (as PD patient urine or spent dialysate) with better than 98% accuracy, sensitivity, and specificity. RametrixTM was able to identify “unknown” urine specimens as from PD patients or healthy human volunteers with better than 96% accuracy (with better than 97% sensitivity and 94% specificity). This demonstrates that an entire Raman spectrum of a urine or spent dialysate specimen can be used to determine its identity or the presence of ESKD by the donor.

Suggested Citation

  • Ryan S Senger & Meaghan Sullivan & Austin Gouldin & Stephanie Lundgren & Kristen Merrifield & Caitlin Steen & Emily Baker & Tommy Vu & Ben Agnor & Gabrielle Martinez & Hana Coogan & William Carswell &, 2020. "Spectral characteristics of urine from patients with end-stage kidney disease analyzed using Raman Chemometric Urinalysis (Rametrix)," PLOS ONE, Public Library of Science, vol. 15(1), pages 1-12, January.
    • Handle: RePEc:plo:pone00:0227281
    DOI: 10.1371/journal.pone.0227281
    as

    Download full text from publisher

    File URL: https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0227281
    Download Restriction: no
    File URL: https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0227281&type=printable
    Download Restriction: no
    File URL: https://libkey.io/10.1371/journal.pone.0227281?utm_source=ideas
    LibKey link: if access is restricted and if your library uses this service, LibKey will redirect you to where you can use your library subscription to access this item
    ---><---

    References listed on IDEAS

    as
    1. Paul T E Cusack, 2020. "The Human Brain," Biomedical Journal of Scientific & Technical Research, Biomedical Research Network+, LLC, vol. 31(3), pages 24261-24266, October.
    2. Adam Shardlow & Natasha J McIntyre & Simon D S Fraser & Paul Roderick & James Raftery & Richard J Fluck & Christopher W McIntyre & Maarten W Taal, 2017. "The clinical utility and cost impact of cystatin C measurement in the diagnosis and management of chronic kidney disease: A primary care cohort study," PLOS Medicine, Public Library of Science, vol. 14(10), pages 1-18, October.
    Full references (including those not matched with items on IDEAS)

    Most related items

    These are the items that most often cite the same works as this one and are cited by the same works as this one.
    1. Abigail B. Schneider & Bridget Leonard, 2022. "From anxiety to control: Mask‐wearing, perceived marketplace influence, and emotional well‐being during the COVID‐19 pandemic," Journal of Consumer Affairs, Wiley Blackwell, vol. 56(1), pages 97-119, March.
    2. Odelaisy León-Triana & Julián Pérez-Beteta & David Albillo & Ana Ortiz de Mendivil & Luis Pérez-Romasanta & Elisabet González-Del Portillo & Manuel Llorente & Natalia Carballo & Estanislao Arana & Víc, 2021. "Brain Metastasis Response to Stereotactic Radio Surgery: A Mathematical Approach," Mathematics, MDPI, vol. 9(7), pages 1-19, March.
    3. Mirren Charnley & Saba Islam & Guneet K. Bindra & Jeremy Engwirda & Julian Ratcliffe & Jiangtao Zhou & Raffaele Mezzenga & Mark D. Hulett & Kyunghoon Han & Joshua T. Berryman & Nicholas P. Reynolds, 2022. "Neurotoxic amyloidogenic peptides in the proteome of SARS-COV2: potential implications for neurological symptoms in COVID-19," Nature Communications, Nature, vol. 13(1), pages 1-11, December.
    4. Hamed Nili & Alexander Walther & Arjen Alink & Nikolaus Kriegeskorte, 2020. "Inferring exemplar discriminability in brain representations," PLOS ONE, Public Library of Science, vol. 15(6), pages 1-28, June.
    5. Linzmajer, Marc & Hubert, Mirja & Hubert, Marco, 2021. "It’s about the process, not the result: An fMRI approach to explore the encoding of explicit and implicit price information," Journal of Economic Psychology, Elsevier, vol. 86(C).
    6. Natalie J Shook & Barış Sevi & Jerin Lee & Benjamin Oosterhoff & Holly N Fitzgerald, 2020. "Disease avoidance in the time of COVID-19: The behavioral immune system is associated with concern and preventative health behaviors," PLOS ONE, Public Library of Science, vol. 15(8), pages 1-15, August.
    7. Cristina Lázaro-Pérez & José Ángel Martínez-López & José Gómez-Galán, 2020. "Addictions in Spanish College Students in Confinement Times: Preventive and Social Perspective," Social Sciences, MDPI, vol. 9(11), pages 1-21, October.
    8. Yashika Arora & Pushpinder Walia & Mitsuhiro Hayashibe & Makii Muthalib & Shubhajit Roy Chowdhury & Stephane Perrey & Anirban Dutta, 2021. "Grey-box modeling and hypothesis testing of functional near-infrared spectroscopy-based cerebrovascular reactivity to anodal high-definition tDCS in healthy humans," PLOS Computational Biology, Public Library of Science, vol. 17(10), pages 1-38, October.
    9. Elvisa Drishti & Bresena Kopliku & Drini Imami, 2022. "Active political engagement, political patronage and local labour markets – The example of Shkoder," International Journal of Manpower, Emerald Group Publishing Limited, vol. 44(6), pages 1118-1142, April.
    10. Nguyen, Ha Trong & Brinkman, Sally & Le, Huong Thu & Zubrick, Stephen R. & Mitrou, Francis, 2022. "Gender differences in time allocation contribute to differences in developmental outcomes in children and adolescents," Economics of Education Review, Elsevier, vol. 89(C).
    11. Gricelda Herrera-Franco & Néstor Montalván-Burbano & Carlos Mora-Frank & Lady Bravo-Montero, 2021. "Scientific Research in Ecuador: A Bibliometric Analysis," Publications, MDPI, vol. 9(4), pages 1-34, December.
    12. Sofie L. Valk & Ting Xu & Casey Paquola & Bo-yong Park & Richard A. I. Bethlehem & Reinder Vos de Wael & Jessica Royer & Shahrzad Kharabian Masouleh & Şeyma Bayrak & Peter Kochunov & B. T. Thomas Yeo , 2022. "Genetic and phylogenetic uncoupling of structure and function in human transmodal cortex," Nature Communications, Nature, vol. 13(1), pages 1-17, December.
    13. Rosen Valchev & Cosmin Ilut, 2017. "Economic Agents as Imperfect Problem Solvers," 2017 Meeting Papers 1285, Society for Economic Dynamics.
    14. Florent Meyniel, 2020. "Brain dynamics for confidence-weighted learning," PLOS Computational Biology, Public Library of Science, vol. 16(6), pages 1-27, June.
    15. Virgilio Pérez & Cristina Aybar & Jose M. Pavía, 2021. "COVID-19 and Changes in Social Habits. Restaurant Terraces, a Booming Space in Cities. The Case of Madrid," Mathematics, MDPI, vol. 9(17), pages 1-18, September.
    16. Ana-Madalina Potcovaru, 2020. "The Impact Of Organizational Stress On The Human Resources From The Health System During Covid-19 Pandemic," Business Excellence and Management, Faculty of Management, Academy of Economic Studies, Bucharest, Romania, vol. 10(5), pages 88-97, October.
    17. Bastien Berret & Frédéric Jean, 2020. "Stochastic optimal open-loop control as a theory of force and impedance planning via muscle co-contraction," PLOS Computational Biology, Public Library of Science, vol. 16(2), pages 1-28, February.
    18. Florencia Barreto-Zarza & Enrique B. Arranz-Freijo, 2022. "Family Context, Parenting and Child Development: An Epigenetic Approach," Social Sciences, MDPI, vol. 11(3), pages 1-13, March.
    19. Alberto Micheletti, 2020. "Modelling cultural selection on biological fitness to integrate social transmission and adaptive explanations for human behaviour," Post-Print hal-02563204, HAL.
    20. Sai Li & T. Tony Cai & Hongzhe Li, 2022. "Transfer learning for high‐dimensional linear regression: Prediction, estimation and minimax optimality," Journal of the Royal Statistical Society Series B, Royal Statistical Society, vol. 84(1), pages 149-173, February.

    More about this item

    Statistics

    Access and download statistics

    Corrections

    All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:plo:pone00:0227281. See general information about how to correct material in RePEc.

    If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

    If CitEc recognized a bibliographic reference but did not link an item in RePEc to it, you can help with this form .

    If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.

    For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: plosone (email available below). General contact details of provider: https://journals.plos.org/plosone/ .

    Please note that corrections may take a couple of weeks to filter through the various RePEc services.

    IDEAS is a RePEc service. RePEc uses bibliographic data supplied by the respective publishers.