IDEAS home Printed from https://ideas.repec.org/a/plo/pone00/0195037.html
   My bibliography  Save this article

Chronic hepatitis B virus and liver fibrosis: A mathematical model

Author

Listed:
  • Avner Friedman
  • Nourridine Siewe

Abstract

Hepatitis B virus (HBV) infection is a liver disorder that can result in cirrhosis, liver failure and hepatocellular carcinoma. HBV infection remains a major global health problem, as it affects more 350 million people chronically and kills roughly 600,000 people annually. Drugs currently used against HBV include IFN-α that decreases viremia, inflammation and the growth of liver fibrosis, and adefovir that decreases the viral load. Each of these drugs can have severe side-effects. In the present paper, we consider the treatment of chronic HBV by a combination of IFN-α and adefovir, and raise the following question: What should be the optimal ratio between IFN-α and adefovir in order to achieve the best ‘efficacy’ under constraints on the total amount of the drugs; here the efficacy is measured by the reduction of the levels of inflammation and of fibrosis? We develop a mathematical model of HBV pathogenesis by a system of partial differential equations (PDEs) and use the model to simulate a ‘synergy map’ which addresses the above question.

Suggested Citation

  • Avner Friedman & Nourridine Siewe, 2018. "Chronic hepatitis B virus and liver fibrosis: A mathematical model," PLOS ONE, Public Library of Science, vol. 13(4), pages 1-23, April.
    • Handle: RePEc:plo:pone00:0195037
    DOI: 10.1371/journal.pone.0195037
    as

    Download full text from publisher

    File URL: https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0195037
    Download Restriction: no
    File URL: https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0195037&type=printable
    Download Restriction: no
    File URL: https://libkey.io/10.1371/journal.pone.0195037?utm_source=ideas
    LibKey link: if access is restricted and if your library uses this service, LibKey will redirect you to where you can use your library subscription to access this item
    ---><---

    References listed on IDEAS

    as
    1. Kevin J. Maloy & Fiona Powrie, 2011. "Intestinal homeostasis and its breakdown in inflammatory bowel disease," Nature, Nature, vol. 474(7351), pages 298-306, June.
    2. Katrin D. Mayer-Barber & Bruno B. Andrade & Sandra D. Oland & Eduardo P. Amaral & Daniel L. Barber & Jacqueline Gonzales & Steven C. Derrick & Ruiru Shi & Nathella Pavan Kumar & Wang Wei & Xing Yuan &, 2014. "Host-directed therapy of tuberculosis based on interleukin-1 and type I interferon crosstalk," Nature, Nature, vol. 511(7507), pages 99-103, July.
    3. Stanca Ciupe & Anne Catlla & Jonathan Forde & David Schaeffer, 2011. "Dynamics of Hepatitis B Virus Infection: What Causes Viral Clearance?," Mathematical Population Studies, Taylor & Francis Journals, vol. 18(2), pages 87-105.
    Full references (including those not matched with items on IDEAS)

    Most related items

    These are the items that most often cite the same works as this one and are cited by the same works as this one.
    1. Lijun Dong & Jingwen Xie & Youyi Wang & Honglian Jiang & Kai Chen & Dantong Li & Jing Wang & Yunzhi Liu & Jia He & Jia Zhou & Liyun Zhang & Xiao Lu & Xiaoming Zou & Xiang-Yang Wang & Qingqing Wang & Z, 2022. "Mannose ameliorates experimental colitis by protecting intestinal barrier integrity," Nature Communications, Nature, vol. 13(1), pages 1-17, December.
    2. Chien-Yu Lin & Kuo-Sen Tseng & Jui-Ming Liu & Heng-Chang Chuang & Chi-Hone Lien & Yi-Chih Chen & Chun-Ying Lai & Cheng-Ping Yu & Ren-Jun Hsu, 2018. "Increased Risk of Ulcerative Colitis in Patients with Periodontal Disease: A Nationwide Population-Based Cohort Study," IJERPH, MDPI, vol. 15(11), pages 1-12, November.
    3. Sujin Kang & Jaekyung Kim & Areum Park & Minsoo Koh & Wonji Shin & Gayoung Park & Taeyun A. Lee & Hyung Jin Kim & Heonjong Han & Yongbo Kim & Myung Kyung Choi & Jae Hyung Park & Eunhye Lee & Hyun-Soo , 2023. "TRIM40 is a pathogenic driver of inflammatory bowel disease subverting intestinal barrier integrity," Nature Communications, Nature, vol. 14(1), pages 1-14, December.
    4. Kerl, Hermann-Johannes & Langemann, Dirk & Vollrath, Antje, 2012. "Reaction diffusion equations and the chronification of liver infections," Mathematics and Computers in Simulation (MATCOM), Elsevier, vol. 82(11), pages 2145-2156.
    5. Urszula Radzikowska & Andrzej Eljaszewicz & Ge Tan & Nino Stocker & Anja Heider & Patrick Westermann & Silvio Steiner & Anita Dreher & Paulina Wawrzyniak & Beate Rückert & Juan Rodriguez-Coira & Damir, 2023. "Rhinovirus-induced epithelial RIG-I inflammasome suppresses antiviral immunity and promotes inflammation in asthma and COVID-19," Nature Communications, Nature, vol. 14(1), pages 1-22, December.
    6. Chao Yang & Mahesh Bachu & Yong Du & Caroline Brauner & Ruoxi Yuan & Marie Dominique Ah Kioon & Giancarlo Chesi & Franck J. Barrat & Lionel B. Ivashkiv, 2022. "CXCL4 synergizes with TLR8 for TBK1-IRF5 activation, epigenomic remodeling and inflammatory response in human monocytes," Nature Communications, Nature, vol. 13(1), pages 1-18, December.
    7. Tae Gun Kang & Kee Woong Kwon & Kyungsoo Kim & Insuk Lee & Myeong Joon Kim & Sang-Jun Ha & Sung Jae Shin, 2022. "Viral coinfection promotes tuberculosis immunopathogenesis by type I IFN signaling-dependent impediment of Th1 cell pulmonary influx," Nature Communications, Nature, vol. 13(1), pages 1-19, December.

    More about this item

    Statistics

    Access and download statistics

    Corrections

    All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:plo:pone00:0195037. See general information about how to correct material in RePEc.

    If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

    If CitEc recognized a bibliographic reference but did not link an item in RePEc to it, you can help with this form .

    If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.

    For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: plosone (email available below). General contact details of provider: https://journals.plos.org/plosone/ .

    Please note that corrections may take a couple of weeks to filter through the various RePEc services.

    IDEAS is a RePEc service. RePEc uses bibliographic data supplied by the respective publishers.