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Rhinovirus-induced epithelial RIG-I inflammasome suppresses antiviral immunity and promotes inflammation in asthma and COVID-19

Author

Listed:
  • Urszula Radzikowska

    (University of Zurich
    Christine Kühne – Center for Allergy Research and Education (CK-CARE)
    Medical University of Bialystok)

  • Andrzej Eljaszewicz

    (University of Zurich
    Christine Kühne – Center for Allergy Research and Education (CK-CARE)
    Medical University of Bialystok)

  • Ge Tan

    (University of Zurich
    ETH Zurich/University of Zurich)

  • Nino Stocker

    (University of Zurich)

  • Anja Heider

    (University of Zurich)

  • Patrick Westermann

    (University of Zurich)

  • Silvio Steiner

    (Institute of Virology and Immunology (IVI)
    University of Bern
    University of Bern)

  • Anita Dreher

    (University of Zurich
    Christine Kühne – Center for Allergy Research and Education (CK-CARE))

  • Paulina Wawrzyniak

    (University of Zurich
    Christine Kühne – Center for Allergy Research and Education (CK-CARE)
    University Children’s Hospital Zurich
    University Children’s Hospital Zurich)

  • Beate Rückert

    (University of Zurich)

  • Juan Rodriguez-Coira

    (University of Zurich
    Universidad San Pablo-CEU
    Universidad San Pablo-CEU)

  • Damir Zhakparov

    (University of Zurich)

  • Mengting Huang

    (University of Zurich)

  • Bogdan Jakiela

    (Jagiellonian University Medical College)

  • Marek Sanak

    (Jagiellonian University Medical College)

  • Marcin Moniuszko

    (Medical University of Bialystok
    Medical University of Bialystok)

  • Liam O’Mahony

    (University of Zurich
    University College Cork)

  • Marek Jutel

    (Wroclaw Medical University
    ALL-MED Medical Research Institute)

  • Tatiana Kebadze

    (Imperial College London
    School of Medicine)

  • David J. Jackson

    (King’s College London
    St Thomas‘ Hospital)

  • Michael R. Edwards

    (Imperial College London
    Asthma UK Centre in Allergic Mechanisms of Asthma)

  • Volker Thiel

    (Institute of Virology and Immunology (IVI)
    University of Bern)

  • Sebastian L. Johnston

    (Imperial College London
    Asthma UK Centre in Allergic Mechanisms of Asthma
    Imperial College Healthcare HNS Trust)

  • Cezmi A. Akdis

    (University of Zurich
    Christine Kühne – Center for Allergy Research and Education (CK-CARE))

  • Milena Sokolowska

    (University of Zurich
    Christine Kühne – Center for Allergy Research and Education (CK-CARE))

Abstract

Rhinoviruses and allergens, such as house dust mite are major agents responsible for asthma exacerbations. The influence of pre-existing airway inflammation on the infection with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is largely unknown. We analyse mechanisms of response to viral infection in experimental in vivo rhinovirus infection in healthy controls and patients with asthma, and in in vitro experiments with house dust mite, rhinovirus and SARS-CoV-2 in human primary airway epithelium. Here, we show that rhinovirus infection in patients with asthma leads to an excessive RIG-I inflammasome activation, which diminishes its accessibility for type I/III interferon responses, leading to their early functional impairment, delayed resolution, prolonged viral clearance and unresolved inflammation in vitro and in vivo. Pre-exposure to house dust mite augments this phenomenon by inflammasome priming and auxiliary inhibition of early type I/III interferon responses. Prior infection with rhinovirus followed by SARS-CoV-2 infection augments RIG-I inflammasome activation and epithelial inflammation. Timely inhibition of the epithelial RIG-I inflammasome may lead to more efficient viral clearance and lower the burden of rhinovirus and SARS-CoV-2 infections.

Suggested Citation

  • Urszula Radzikowska & Andrzej Eljaszewicz & Ge Tan & Nino Stocker & Anja Heider & Patrick Westermann & Silvio Steiner & Anita Dreher & Paulina Wawrzyniak & Beate Rückert & Juan Rodriguez-Coira & Damir, 2023. "Rhinovirus-induced epithelial RIG-I inflammasome suppresses antiviral immunity and promotes inflammation in asthma and COVID-19," Nature Communications, Nature, vol. 14(1), pages 1-22, December.
  • Handle: RePEc:nat:natcom:v:14:y:2023:i:1:d:10.1038_s41467-023-37470-4
    DOI: 10.1038/s41467-023-37470-4
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    References listed on IDEAS

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