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Intestinal homeostasis and its breakdown in inflammatory bowel disease

Author

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  • Kevin J. Maloy

    (Sir William Dunn School of Pathology, University of Oxford)

  • Fiona Powrie

    (Sir William Dunn School of Pathology, University of Oxford
    Translational Gastroenterology Unit, University of Oxford, John Radcliffe Hospital)

Abstract

Intestinal homeostasis depends on complex interactions between the microbiota, the intestinal epithelium and the host immune system. Diverse regulatory mechanisms cooperate to maintain intestinal homeostasis, and a breakdown in these pathways may precipitate the chronic inflammatory pathology found in inflammatory bowel disease. It is now evident that immune effector modules that drive intestinal inflammation are conserved across innate and adaptive leukocytes and can be controlled by host regulatory cells. Recent evidence suggests that several factors may tip the balance between homeostasis and intestinal inflammation, presenting future challenges for the development of new therapies for inflammatory bowel disease.

Suggested Citation

  • Kevin J. Maloy & Fiona Powrie, 2011. "Intestinal homeostasis and its breakdown in inflammatory bowel disease," Nature, Nature, vol. 474(7351), pages 298-306, June.
    • Handle: RePEc:nat:nature:v:474:y:2011:i:7351:d:10.1038_nature10208
    DOI: 10.1038/nature10208
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    Cited by:

    1. Avner Friedman & Nourridine Siewe, 2018. "Chronic hepatitis B virus and liver fibrosis: A mathematical model," PLOS ONE, Public Library of Science, vol. 13(4), pages 1-23, April.
    2. Sujin Kang & Jaekyung Kim & Areum Park & Minsoo Koh & Wonji Shin & Gayoung Park & Taeyun A. Lee & Hyung Jin Kim & Heonjong Han & Yongbo Kim & Myung Kyung Choi & Jae Hyung Park & Eunhye Lee & Hyun-Soo , 2023. "TRIM40 is a pathogenic driver of inflammatory bowel disease subverting intestinal barrier integrity," Nature Communications, Nature, vol. 14(1), pages 1-14, December.
    3. Lijun Dong & Jingwen Xie & Youyi Wang & Honglian Jiang & Kai Chen & Dantong Li & Jing Wang & Yunzhi Liu & Jia He & Jia Zhou & Liyun Zhang & Xiao Lu & Xiaoming Zou & Xiang-Yang Wang & Qingqing Wang & Z, 2022. "Mannose ameliorates experimental colitis by protecting intestinal barrier integrity," Nature Communications, Nature, vol. 13(1), pages 1-17, December.
    4. Chien-Yu Lin & Kuo-Sen Tseng & Jui-Ming Liu & Heng-Chang Chuang & Chi-Hone Lien & Yi-Chih Chen & Chun-Ying Lai & Cheng-Ping Yu & Ren-Jun Hsu, 2018. "Increased Risk of Ulcerative Colitis in Patients with Periodontal Disease: A Nationwide Population-Based Cohort Study," IJERPH, MDPI, vol. 15(11), pages 1-12, November.

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