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Host-directed therapy of tuberculosis based on interleukin-1 and type I interferon crosstalk

Author

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  • Katrin D. Mayer-Barber

    (Immunobiology Section, Laboratory of Parasitic Diseases (LPD), National Institute of Allergy and Infectious Diseases (NIAID), National Institutes of Health (NIH))

  • Bruno B. Andrade

    (Immunobiology Section, Laboratory of Parasitic Diseases (LPD), National Institute of Allergy and Infectious Diseases (NIAID), National Institutes of Health (NIH))

  • Sandra D. Oland

    (Immunobiology Section, Laboratory of Parasitic Diseases (LPD), National Institute of Allergy and Infectious Diseases (NIAID), National Institutes of Health (NIH))

  • Eduardo P. Amaral

    (Immunobiology Section, Laboratory of Parasitic Diseases (LPD), National Institute of Allergy and Infectious Diseases (NIAID), National Institutes of Health (NIH)
    Biomedical Sciences Institutes, University of Sao Paulo, 05508-900 Sao Paulo, Brazil)

  • Daniel L. Barber

    (T Lymphocyte Biology Unit, LPD, NIAID, NIH, Bethesda, Maryland 20892, USA)

  • Jacqueline Gonzales

    (Tuberculosis Research Section, Laboratory of Clinical Infectious Disease, NIAID, NIH, Bethesda, Maryland 20892, USA)

  • Steven C. Derrick

    (Center for Biologics Evaluation and Research, Food and Drug Administration)

  • Ruiru Shi

    (Henan Chest Hospital)

  • Nathella Pavan Kumar

    (NIH, International Center for Excellence in Research, 600 031 Chennai, India
    National Institute for Research in Tuberculosis (NIRT), 600 031 Chennai, India)

  • Wang Wei

    (Henan Chest Hospital)

  • Xing Yuan

    (Henan Chest Hospital)

  • Guolong Zhang

    (Sino-US International Research Center for Tuberculosis, and Henan Public Health Center)

  • Ying Cai

    (Tuberculosis Research Section, Laboratory of Clinical Infectious Disease, NIAID, NIH, Bethesda, Maryland 20892, USA)

  • Subash Babu

    (NIH, International Center for Excellence in Research, 600 031 Chennai, India
    Helminth Immunology Section, LPD, NIAID, NIH, Bethesda, Maryland 20892, USA)

  • Marta Catalfamo

    (Clinical and Molecular Retrovirology Section, Laboratory of Immunoregulation, NIAID, NIH, Bethesda, Maryland 20892, USA)

  • Andres M. Salazar

    (Oncovir Inc.)

  • Laura E. Via

    (Tuberculosis Research Section, Laboratory of Clinical Infectious Disease, NIAID, NIH, Bethesda, Maryland 20892, USA)

  • Clifton E. Barry III

    (Tuberculosis Research Section, Laboratory of Clinical Infectious Disease, NIAID, NIH, Bethesda, Maryland 20892, USA)

  • Alan Sher

    (Immunobiology Section, Laboratory of Parasitic Diseases (LPD), National Institute of Allergy and Infectious Diseases (NIAID), National Institutes of Health (NIH))

Abstract

Active tuberculosis has been linked to excessive type I interferon induction whereas interleukin-1 may have protective effects; here it is shown that interleukin-1 enhances the production of prostaglandin E2, which helps contain the pathogen while also suppressing detrimental type I interferon.

Suggested Citation

  • Katrin D. Mayer-Barber & Bruno B. Andrade & Sandra D. Oland & Eduardo P. Amaral & Daniel L. Barber & Jacqueline Gonzales & Steven C. Derrick & Ruiru Shi & Nathella Pavan Kumar & Wang Wei & Xing Yuan &, 2014. "Host-directed therapy of tuberculosis based on interleukin-1 and type I interferon crosstalk," Nature, Nature, vol. 511(7507), pages 99-103, July.
    • Handle: RePEc:nat:nature:v:511:y:2014:i:7507:d:10.1038_nature13489
    DOI: 10.1038/nature13489
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    Cited by:

    1. Avner Friedman & Nourridine Siewe, 2018. "Chronic hepatitis B virus and liver fibrosis: A mathematical model," PLOS ONE, Public Library of Science, vol. 13(4), pages 1-23, April.
    2. Urszula Radzikowska & Andrzej Eljaszewicz & Ge Tan & Nino Stocker & Anja Heider & Patrick Westermann & Silvio Steiner & Anita Dreher & Paulina Wawrzyniak & Beate Rückert & Juan Rodriguez-Coira & Damir, 2023. "Rhinovirus-induced epithelial RIG-I inflammasome suppresses antiviral immunity and promotes inflammation in asthma and COVID-19," Nature Communications, Nature, vol. 14(1), pages 1-22, December.
    3. Tae Gun Kang & Kee Woong Kwon & Kyungsoo Kim & Insuk Lee & Myeong Joon Kim & Sang-Jun Ha & Sung Jae Shin, 2022. "Viral coinfection promotes tuberculosis immunopathogenesis by type I IFN signaling-dependent impediment of Th1 cell pulmonary influx," Nature Communications, Nature, vol. 13(1), pages 1-19, December.
    4. Chao Yang & Mahesh Bachu & Yong Du & Caroline Brauner & Ruoxi Yuan & Marie Dominique Ah Kioon & Giancarlo Chesi & Franck J. Barrat & Lionel B. Ivashkiv, 2022. "CXCL4 synergizes with TLR8 for TBK1-IRF5 activation, epigenomic remodeling and inflammatory response in human monocytes," Nature Communications, Nature, vol. 13(1), pages 1-18, December.

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