IDEAS home Printed from https://ideas.repec.org/a/nat/nature/v511y2014i7507d10.1038_nature13489.html
   My bibliography  Save this article

Host-directed therapy of tuberculosis based on interleukin-1 and type I interferon crosstalk

Author

Listed:
  • Katrin D. Mayer-Barber

    (Immunobiology Section, Laboratory of Parasitic Diseases (LPD), National Institute of Allergy and Infectious Diseases (NIAID), National Institutes of Health (NIH))

  • Bruno B. Andrade

    (Immunobiology Section, Laboratory of Parasitic Diseases (LPD), National Institute of Allergy and Infectious Diseases (NIAID), National Institutes of Health (NIH))

  • Sandra D. Oland

    (Immunobiology Section, Laboratory of Parasitic Diseases (LPD), National Institute of Allergy and Infectious Diseases (NIAID), National Institutes of Health (NIH))

  • Eduardo P. Amaral

    (Immunobiology Section, Laboratory of Parasitic Diseases (LPD), National Institute of Allergy and Infectious Diseases (NIAID), National Institutes of Health (NIH)
    Biomedical Sciences Institutes, University of Sao Paulo, 05508-900 Sao Paulo, Brazil)

  • Daniel L. Barber

    (T Lymphocyte Biology Unit, LPD, NIAID, NIH, Bethesda, Maryland 20892, USA)

  • Jacqueline Gonzales

    (Tuberculosis Research Section, Laboratory of Clinical Infectious Disease, NIAID, NIH, Bethesda, Maryland 20892, USA)

  • Steven C. Derrick

    (Center for Biologics Evaluation and Research, Food and Drug Administration)

  • Ruiru Shi

    (Henan Chest Hospital)

  • Nathella Pavan Kumar

    (NIH, International Center for Excellence in Research, 600 031 Chennai, India
    National Institute for Research in Tuberculosis (NIRT), 600 031 Chennai, India)

  • Wang Wei

    (Henan Chest Hospital)

  • Xing Yuan

    (Henan Chest Hospital)

  • Guolong Zhang

    (Sino-US International Research Center for Tuberculosis, and Henan Public Health Center)

  • Ying Cai

    (Tuberculosis Research Section, Laboratory of Clinical Infectious Disease, NIAID, NIH, Bethesda, Maryland 20892, USA)

  • Subash Babu

    (NIH, International Center for Excellence in Research, 600 031 Chennai, India
    Helminth Immunology Section, LPD, NIAID, NIH, Bethesda, Maryland 20892, USA)

  • Marta Catalfamo

    (Clinical and Molecular Retrovirology Section, Laboratory of Immunoregulation, NIAID, NIH, Bethesda, Maryland 20892, USA)

  • Andres M. Salazar

    (Oncovir Inc.)

  • Laura E. Via

    (Tuberculosis Research Section, Laboratory of Clinical Infectious Disease, NIAID, NIH, Bethesda, Maryland 20892, USA)

  • Clifton E. Barry III

    (Tuberculosis Research Section, Laboratory of Clinical Infectious Disease, NIAID, NIH, Bethesda, Maryland 20892, USA)

  • Alan Sher

    (Immunobiology Section, Laboratory of Parasitic Diseases (LPD), National Institute of Allergy and Infectious Diseases (NIAID), National Institutes of Health (NIH))

Abstract

Active tuberculosis has been linked to excessive type I interferon induction whereas interleukin-1 may have protective effects; here it is shown that interleukin-1 enhances the production of prostaglandin E2, which helps contain the pathogen while also suppressing detrimental type I interferon.

Suggested Citation

  • Katrin D. Mayer-Barber & Bruno B. Andrade & Sandra D. Oland & Eduardo P. Amaral & Daniel L. Barber & Jacqueline Gonzales & Steven C. Derrick & Ruiru Shi & Nathella Pavan Kumar & Wang Wei & Xing Yuan &, 2014. "Host-directed therapy of tuberculosis based on interleukin-1 and type I interferon crosstalk," Nature, Nature, vol. 511(7507), pages 99-103, July.
    • Handle: RePEc:nat:nature:v:511:y:2014:i:7507:d:10.1038_nature13489
    DOI: 10.1038/nature13489
    as

    Download full text from publisher

    File URL: https://www.nature.com/articles/nature13489
    File Function: Abstract
    Download Restriction: Access to the full text of the articles in this series is restricted.
    File URL: https://libkey.io/10.1038/nature13489?utm_source=ideas
    LibKey link: if access is restricted and if your library uses this service, LibKey will redirect you to where you can use your library subscription to access this item
    ---><---

    As the access to this document is restricted, you may want to search for a different version of it.

    Citations

    Citations are extracted by the CitEc Project, subscribe to its RSS feed for this item.
    as


    Cited by:

    1. Urszula Radzikowska & Andrzej Eljaszewicz & Ge Tan & Nino Stocker & Anja Heider & Patrick Westermann & Silvio Steiner & Anita Dreher & Paulina Wawrzyniak & Beate Rückert & Juan Rodriguez-Coira & Damir, 2023. "Rhinovirus-induced epithelial RIG-I inflammasome suppresses antiviral immunity and promotes inflammation in asthma and COVID-19," Nature Communications, Nature, vol. 14(1), pages 1-22, December.
    2. Tae Gun Kang & Kee Woong Kwon & Kyungsoo Kim & Insuk Lee & Myeong Joon Kim & Sang-Jun Ha & Sung Jae Shin, 2022. "Viral coinfection promotes tuberculosis immunopathogenesis by type I IFN signaling-dependent impediment of Th1 cell pulmonary influx," Nature Communications, Nature, vol. 13(1), pages 1-19, December.
    3. Avner Friedman & Nourridine Siewe, 2018. "Chronic hepatitis B virus and liver fibrosis: A mathematical model," PLOS ONE, Public Library of Science, vol. 13(4), pages 1-23, April.
    4. Chao Yang & Mahesh Bachu & Yong Du & Caroline Brauner & Ruoxi Yuan & Marie Dominique Ah Kioon & Giancarlo Chesi & Franck J. Barrat & Lionel B. Ivashkiv, 2022. "CXCL4 synergizes with TLR8 for TBK1-IRF5 activation, epigenomic remodeling and inflammatory response in human monocytes," Nature Communications, Nature, vol. 13(1), pages 1-18, December.

    More about this item

    Statistics

    Access and download statistics

    Corrections

    All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:nat:nature:v:511:y:2014:i:7507:d:10.1038_nature13489. See general information about how to correct material in RePEc.

    If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

    We have no bibliographic references for this item. You can help adding them by using this form .

    If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.

    For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: Sonal Shukla or Springer Nature Abstracting and Indexing (email available below). General contact details of provider: http://www.nature.com .

    Please note that corrections may take a couple of weeks to filter through the various RePEc services.

    IDEAS is a RePEc service. RePEc uses bibliographic data supplied by the respective publishers.