IDEAS home Printed from https://ideas.repec.org/a/gam/jijerp/v15y2018i11p2602-d184443.html
   My bibliography  Save this article

Increased Risk of Ulcerative Colitis in Patients with Periodontal Disease: A Nationwide Population-Based Cohort Study

Author

Listed:
  • Chien-Yu Lin

    (Department of Pediatrics, Hsinchu MacKay Memorial Hospital, Hsinchu city 300, Taiwan
    C.-Y.L. (Chien-Yu Lin) and K.-S.T. contributed to this work equally.)

  • Kuo-Sen Tseng

    (Division of Rheumatology, Department of Internal Medicine, Taoyuan General Hospital, Ministry of Health and Welfare, Taoyuan 330, Taiwan
    C.-Y.L. (Chien-Yu Lin) and K.-S.T. contributed to this work equally.)

  • Jui-Ming Liu

    (Division of Urology, Department of Surgery, Taoyuan General Hospital, Ministry of Health and Welfare, Taoyuan 330, Taiwan
    Graduate Institute of Life Sciences, National Defense Medical Center, Taipei 114, Taiwan)

  • Heng-Chang Chuang

    (Division of Urology, Department of Surgery, Taoyuan General Hospital, Ministry of Health and Welfare, Taoyuan 330, Taiwan)

  • Chi-Hone Lien

    (Department of Pediatrics, Hsinchu MacKay Memorial Hospital, Hsinchu city 300, Taiwan)

  • Yi-Chih Chen

    (Department of Pediatrics, Hsinchu MacKay Memorial Hospital, Hsinchu city 300, Taiwan)

  • Chun-Ying Lai

    (Division of Gastroenterology, Department of Internal Medicine, Taoyuan General Hospital, Ministry of Health and Welfare, Taoyuan 330, Taiwan
    C.-Y.L. (Chun-Ying Lai), C.-P.Y. and R.-J.H. contributed to this work equally.)

  • Cheng-Ping Yu

    (Biobank Management Center of the Tri-Service General Hospital, National Defense Medical Center, Taipei 114, Taiwan
    Department of Pathology and Graduate Institute of Pathology and Parasitology, The Tri-Service General Hospital, National Defense Medical Center, Taipei 114, Taiwan
    C.-Y.L. (Chun-Ying Lai), C.-P.Y. and R.-J.H. contributed to this work equally.)

  • Ren-Jun Hsu

    (Graduate Institute of Life Sciences, National Defense Medical Center, Taipei 114, Taiwan
    Biobank Management Center of the Tri-Service General Hospital, National Defense Medical Center, Taipei 114, Taiwan
    Department of Pathology and Graduate Institute of Pathology and Parasitology, The Tri-Service General Hospital, National Defense Medical Center, Taipei 114, Taiwan
    C.-Y.L. (Chun-Ying Lai), C.-P.Y. and R.-J.H. contributed to this work equally.)

Abstract

Both periodontal disease (PD) and inflammatory bowel disease (IBD), including Crohn’s disease (CD) and ulcerative colitis (UC), are important diseases of the alimentary tract. Microbiome and immune-mediated inflammatory processes play important roles in these diseases. An association between PD and IBD may exist. This study investigated the risk of IBD in patients with PD. This study used data from the National Health Insurance Research Database of Taiwan from 1996 to 2013. A total of 27,041 patients with PD were enrolled as a study group, and 108,149 patients without PD were selected as the control group after matching by gender, age, insured region, urbanization, and income with a 1:4 ratio. Cox proportional hazards regression was used to calculate the risk of IBD. Of the 135,190 participants enrolled in this study, 5392 (4%) with newly diagnosed IBD were identified. The overall incidence of subsequent IBD was similar in both groups (3.8% vs. 4%, adjusted hazard ratio (aHR) = 1.01, 95% confidence interval (CI): 0.94–1.08). However, an increased risk of UC in the PD group was found after adjusting confounding factors (aHR: 1.56, 95% CI: 1.13–2.15; p < 0.05). This study demonstrated that patients with PD had approximately one-half higher risk of subsequent UC. Further studies are warranted to elucidate the relationship between PD and UC.

Suggested Citation

  • Chien-Yu Lin & Kuo-Sen Tseng & Jui-Ming Liu & Heng-Chang Chuang & Chi-Hone Lien & Yi-Chih Chen & Chun-Ying Lai & Cheng-Ping Yu & Ren-Jun Hsu, 2018. "Increased Risk of Ulcerative Colitis in Patients with Periodontal Disease: A Nationwide Population-Based Cohort Study," IJERPH, MDPI, vol. 15(11), pages 1-12, November.
    • Handle: RePEc:gam:jijerp:v:15:y:2018:i:11:p:2602-:d:184443
    as

    Download full text from publisher

    File URL: https://www.mdpi.com/1660-4601/15/11/2602/pdf
    Download Restriction: no
    File URL: https://www.mdpi.com/1660-4601/15/11/2602/
    Download Restriction: no
    ---><---

    References listed on IDEAS

    as
    1. Kevin J. Maloy & Fiona Powrie, 2011. "Intestinal homeostasis and its breakdown in inflammatory bowel disease," Nature, Nature, vol. 474(7351), pages 298-306, June.
    Full references (including those not matched with items on IDEAS)

    Most related items

    These are the items that most often cite the same works as this one and are cited by the same works as this one.
    1. Lijun Dong & Jingwen Xie & Youyi Wang & Honglian Jiang & Kai Chen & Dantong Li & Jing Wang & Yunzhi Liu & Jia He & Jia Zhou & Liyun Zhang & Xiao Lu & Xiaoming Zou & Xiang-Yang Wang & Qingqing Wang & Z, 2022. "Mannose ameliorates experimental colitis by protecting intestinal barrier integrity," Nature Communications, Nature, vol. 13(1), pages 1-17, December.
    2. Sujin Kang & Jaekyung Kim & Areum Park & Minsoo Koh & Wonji Shin & Gayoung Park & Taeyun A. Lee & Hyung Jin Kim & Heonjong Han & Yongbo Kim & Myung Kyung Choi & Jae Hyung Park & Eunhye Lee & Hyun-Soo , 2023. "TRIM40 is a pathogenic driver of inflammatory bowel disease subverting intestinal barrier integrity," Nature Communications, Nature, vol. 14(1), pages 1-14, December.
    3. Avner Friedman & Nourridine Siewe, 2018. "Chronic hepatitis B virus and liver fibrosis: A mathematical model," PLOS ONE, Public Library of Science, vol. 13(4), pages 1-23, April.

    Corrections

    All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:gam:jijerp:v:15:y:2018:i:11:p:2602-:d:184443. See general information about how to correct material in RePEc.

    If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

    If CitEc recognized a bibliographic reference but did not link an item in RePEc to it, you can help with this form .

    If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.

    For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: MDPI Indexing Manager (email available below). General contact details of provider: https://www.mdpi.com .

    Please note that corrections may take a couple of weeks to filter through the various RePEc services.

    IDEAS is a RePEc service. RePEc uses bibliographic data supplied by the respective publishers.