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Efficacy and tolerability of short-term duloxetine treatment in adults with generalized anxiety disorder: A meta-analysis

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  • Xinyuan Li
  • Lijun Zhu
  • Chunkui Zhou
  • Jing Liu
  • Heqian Du
  • Chenglin Wang
  • Shaokuan Fang

Abstract

Objective: To investigate the efficacy and tolerability of duloxetine during short-term treatment in adults with generalized anxiety disorder (GAD). Methods: We conducted a comprehensive literature review of the PubMed, Embase, Cochrane Central Register of Controlled Trials, Web of Science, and ClinicalTrials databases for randomized controlled trials(RCTs) comparing duloxetine or duloxetine plus other antipsychotics with placebo for the treatment of GAD in adults. Outcome measures were (1) efficacy, assessed by the Hospital Anxiety and Depression Scale(HADS) anxiety subscale score, the Hamilton Rating Scale for Anxiety(HAM-A) psychic and somatic anxiety factor scores, and response and remission rates based on total scores of HAM-A; (2) tolerability, assessed by discontinuation rate due to adverse events, the incidence of treatment emergent adverse events(TEAEs) and serious adverse events(SAEs). Review Manager 5.3 and Stata Version 12.0 software were used for all statistical analyses. Results: The meta-analysis included 8 RCTs. Mean changes in the HADS anxiety subscale score [mean difference(MD) = 2.32, 95% confidence interval(CI) 1.77–2.88, P

Suggested Citation

  • Xinyuan Li & Lijun Zhu & Chunkui Zhou & Jing Liu & Heqian Du & Chenglin Wang & Shaokuan Fang, 2018. "Efficacy and tolerability of short-term duloxetine treatment in adults with generalized anxiety disorder: A meta-analysis," PLOS ONE, Public Library of Science, vol. 13(3), pages 1-15, March.
    • Handle: RePEc:plo:pone00:0194501
    DOI: 10.1371/journal.pone.0194501
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    References listed on IDEAS

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    1. Xinyuan Li & Lijun Zhu & Yingying Su & Shaokuan Fang, 2017. "Short-term efficacy and tolerability of venlafaxine extended release in adults with generalized anxiety disorder without depression: A meta-analysis," PLOS ONE, Public Library of Science, vol. 12(10), pages 1-14, October.
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    5. David Moher & Alessandro Liberati & Jennifer Tetzlaff & Douglas G Altman & The PRISMA Group, 2009. "Preferred Reporting Items for Systematic Reviews and Meta-Analyses: The PRISMA Statement," PLOS Medicine, Public Library of Science, vol. 6(7), pages 1-6, July.
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