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Patients with subclinical hypothyroidism before 20 weeks of pregnancy have a higher risk of miscarriage: A systematic review and meta-analysis

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  • Yibing Zhang
  • Haoyu Wang
  • Xifeng Pan
  • Weiping Teng
  • Zhongyan Shan

Abstract

Objective: To evaluate the relationship between subclinical hypothyroidism (SCH) and the risk of miscarriage before 20 weeks of pregnancy. Methods: Literature databases were searched, including the PubMed, Web of Science, Embase and Cochrane databases, from January 1, 1980, to December 31, 2015. The following search terms were used: subclinical hypothyroidism, hypothyroidism, thyroid dysfunction, thyroid hypofunction, subclinical thyroid disease, thyroid dysfunction, pregnancy loss, abortion and miscarriage. Studies comparing the prevalence of miscarriage in pregnant women with SCH with those who were euthyroid were selected. From the studies matched, the relative risk (RR) and corresponding 95% confidence interval (95% CI) were calculated to yield outcomes. All the statistical analyses were performed using Review Manager (Revman) Version 5.3 and Stata Version 12.0 software. The publication bias of the studies was assessed by forest plot and Begg’s test, while the stability of the results was evaluated by sensitivity analysis. Results: Nine articles satisfying the inclusion criteria were analysed. Compared to euthyroid pregnant women, patients with non-treated SCH had a higher prevalence of miscarriage (RR = 1.90, 95% CI1.59–2.27, P

Suggested Citation

  • Yibing Zhang & Haoyu Wang & Xifeng Pan & Weiping Teng & Zhongyan Shan, 2017. "Patients with subclinical hypothyroidism before 20 weeks of pregnancy have a higher risk of miscarriage: A systematic review and meta-analysis," PLOS ONE, Public Library of Science, vol. 12(4), pages 1-13, April.
    • Handle: RePEc:plo:pone00:0175708
    DOI: 10.1371/journal.pone.0175708
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    Cited by:

    1. Xinyuan Li & Lijun Zhu & Yingying Su & Shaokuan Fang, 2017. "Short-term efficacy and tolerability of venlafaxine extended release in adults with generalized anxiety disorder without depression: A meta-analysis," PLOS ONE, Public Library of Science, vol. 12(10), pages 1-14, October.
    2. Xu Ke, 2018. "Clinical Study the Relationship between High-TSH Degree and Changes of LDL-C Level in Pregnant Patients’ Serum," Biomedical Journal of Scientific & Technical Research, Biomedical Research Network+, LLC, vol. 2(1), pages 2369-2373, January.
    3. Xinyuan Li & Lijun Zhu & Chunkui Zhou & Jing Liu & Heqian Du & Chenglin Wang & Shaokuan Fang, 2018. "Efficacy and tolerability of short-term duloxetine treatment in adults with generalized anxiety disorder: A meta-analysis," PLOS ONE, Public Library of Science, vol. 13(3), pages 1-15, March.

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