IDEAS home Printed from https://ideas.repec.org/a/plo/pone00/0192658.html
   My bibliography  Save this article

The interaction between cannabis use and the Val158Met polymorphism of the COMT gene in psychosis: A transdiagnostic meta – analysis

Author

Listed:
  • Thomas Stephanus Johannes Vaessen
  • Lea de Jong
  • Annika Theresia Schäfer
  • Thomas Damen
  • Aniek Uittenboogaard
  • Pauline Krolinski
  • Chinyere Vicky Nwosu
  • Florentina Maria Egidius Pinckaers
  • Iris Leah Marije Rotee
  • Antonius Petrus Wilhelmus Smeets
  • Ayşegül Ermiş
  • James L Kennedy
  • Dorien H Nieman
  • Arun Tiwari
  • Jim van Os
  • Marjan Drukker

Abstract

Background: Neither environmental nor genetic factors are sufficient to predict the transdiagnostic expression of psychosis. Therefore, analysis of gene-environment interactions may be productive. Objective: A meta-analysis was performed using papers investigating the interaction between cannabis use and catechol-O-methyl transferase (COMT) polymorphism Val158Met (COMTVal158Met). Data sources: PubMed, Embase, PsychInfo. Study eligibility criteria: All observational studies assessing the interaction between COMTVal158Met and cannabis with any psychosis or psychotic symptoms measure as an outcome. Study appraisal and synthesis methods: A meta-analysis was performed using the Meta-analysis of Observational Studies in Epidemiology guidelines and forest plots were generated. Thirteen articles met the selection criteria: 7 clinical studies using a case-only design, 3 clinical studies with a dichotomous outcome, and 3 studies analysing a continuous outcome of psychotic symptoms below the threshold of psychotic disorder. The three study types were analysed separately. Validity of the included studies was assessed using "A Cochrane Risk of Bias Assessment Tool: for Non-Randomized Studies of Interventions". Results: For case-only studies, a significant interaction was found between cannabis use and COMTVal158Met, with an OR of 1.45 (95% Confidence Interval = 1.05–2.00; Met/Met as the risk genotype). However, there was no evidence for interaction in either the studies including dichotomous outcomes (B = -0.51, 95% Confidence Interval -1.72, 0.70) or the studies including continuous outcomes (B = -0.04 95% Confidence Interval -0.16–0.08). Limitation: A substantial part of the included studies used the case-only design, which has lower validity and tends to overestimate true effects. Conclusion: The interaction term between cannabis use and COMTVal158Met was only statistically significant in the case-only studies, but not in studies using other clinical or non-clinical psychosis outcomes. Future additional high quality studies might change current perspectives, yet currently evidence for the interaction remains unconvincing.

Suggested Citation

  • Thomas Stephanus Johannes Vaessen & Lea de Jong & Annika Theresia Schäfer & Thomas Damen & Aniek Uittenboogaard & Pauline Krolinski & Chinyere Vicky Nwosu & Florentina Maria Egidius Pinckaers & Iris L, 2018. "The interaction between cannabis use and the Val158Met polymorphism of the COMT gene in psychosis: A transdiagnostic meta – analysis," PLOS ONE, Public Library of Science, vol. 13(2), pages 1-22, February.
    • Handle: RePEc:plo:pone00:0192658
    DOI: 10.1371/journal.pone.0192658
    as

    Download full text from publisher

    File URL: https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0192658
    Download Restriction: no
    File URL: https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0192658&type=printable
    Download Restriction: no
    File URL: https://libkey.io/10.1371/journal.pone.0192658?utm_source=ideas
    LibKey link: if access is restricted and if your library uses this service, LibKey will redirect you to where you can use your library subscription to access this item
    ---><---

    References listed on IDEAS

    as
    1. Sue Duval & Richard Tweedie, 2000. "Trim and Fill: A Simple Funnel-Plot–Based Method of Testing and Adjusting for Publication Bias in Meta-Analysis," Biometrics, The International Biometric Society, vol. 56(2), pages 455-463, June.
    Full references (including those not matched with items on IDEAS)

    Most related items

    These are the items that most often cite the same works as this one and are cited by the same works as this one.
    1. Qian Li & Yan Chen & Shikun Sun & Muyuan Zhu & Jing Xue & Zihan Gao & Jinfeng Zhao & Yihe Tang, 2022. "Research on Crop Irrigation Schedules Under Deficit Irrigation—A Meta-analysis," Water Resources Management: An International Journal, Published for the European Water Resources Association (EWRA), Springer;European Water Resources Association (EWRA), vol. 36(12), pages 4799-4817, September.
    2. Bart Verkuil & Serpil Atasayi & Marc L Molendijk, 2015. "Workplace Bullying and Mental Health: A Meta-Analysis on Cross-Sectional and Longitudinal Data," PLOS ONE, Public Library of Science, vol. 10(8), pages 1-16, August.
    3. Damiano Pizzol & Mike Trott & Igor Grabovac & Mario Antunes & Anna Claudia Colangelo & Simona Ippoliti & Cristian Petre Ilie & Anne Carrie & Nicola Veronese & Lee Smith, 2021. "Laparoscopy in Low-Income Countries: 10-Year Experience and Systematic Literature Review," IJERPH, MDPI, vol. 18(11), pages 1-11, May.
    4. Wolfgang Goymann & John C. Wingfield, 2014. "Male-to-female testosterone ratios, dimorphism, and life history—what does it really tell us?," Behavioral Ecology, International Society for Behavioral Ecology, vol. 25(4), pages 685-699.
    5. Alderotti, Giammarco & Rapallini, Chiara & Traverso, Silvio, 2023. "The Big Five personality traits and earnings: A meta-analysis," Journal of Economic Psychology, Elsevier, vol. 94(C).
    6. Ünal, Zehra E. & Kartal, Gamze & Ulusoy, Serra & Ala, Aslı M. & Yilmaz, Munube & Geary, David C., 2023. "Relative contributions of g and basic domain-specific mathematics skills to complex mathematics competencies," Intelligence, Elsevier, vol. 101(C).
    7. Daniele Zago & Maria Eugênia Andrighetto Canozzi & Júlio Otávio Jardim Barcellos, 2020. "Pregnant beef cow’s nutrition and its effects on postnatal weight and carcass quality of their progeny," PLOS ONE, Public Library of Science, vol. 15(8), pages 1-20, August.
    8. Viktoria Maria Baumeister & Leonie Petra Kuen & Maike Bruckes & Gerhard Schewe, 2021. "The Relationship of Work-Related ICT Use With Well-being, Incorporating the Role of Resources and Demands: A Meta-Analysis," SAGE Open, , vol. 11(4), pages 21582440211, November.
    9. Gundula Krack, 2019. "How to make value-based health insurance designs more effective? A systematic review and meta-analysis," The European Journal of Health Economics, Springer;Deutsche Gesellschaft für Gesundheitsökonomie (DGGÖ), vol. 20(6), pages 841-856, August.
    10. Angélica Pigola & Priscila Rezende Costa, 2022. "In search of understanding about knowledge and learning on innovation performance," Scientometrics, Springer;Akadémiai Kiadó, vol. 127(7), pages 3995-4022, July.
    11. Christopher Snyder & Ran Zhuo, 2018. "Sniff Tests as a Screen in the Publication Process: Throwing out the Wheat with the Chaff," NBER Working Papers 25058, National Bureau of Economic Research, Inc.
    12. Chuang Yuan & Jing Wang & Michael Ying, 2016. "Predictive Value of Carotid Distensibility Coefficient for Cardiovascular Diseases and All-Cause Mortality: A Meta-Analysis," PLOS ONE, Public Library of Science, vol. 11(4), pages 1-15, April.
    13. Francisco Javier Blanco-Encomienda & Rocío García-Cantero & María José Latorre-Medina, 2020. "Association between Work-Related Rumination, Work Environment and Employee Well-Being: A Meta-Analytic Study of Main and Moderator Effects," Social Indicators Research: An International and Interdisciplinary Journal for Quality-of-Life Measurement, Springer, vol. 150(3), pages 887-910, August.
    14. Pedro L. Cosio & Manuel Crespo-Posadas & Álvaro Velarde-Sotres & Mireia Pelaez, 2021. "Effect of Chronic Resistance Training on Circulating Irisin: Systematic Review and Meta-Analysis of Randomized Controlled Trials," IJERPH, MDPI, vol. 18(5), pages 1-16, March.
    15. Molo, Fabio & Pawel, Samuel & Fraga González, Gorka, 2024. "A Robustness Reproduction of "A Systematic Review and Meta-Analysis of 90 Cohort Studies of Social Isolation, Loneliness and Mortality"," I4R Discussion Paper Series 169, The Institute for Replication (I4R).
    16. Augusteijn, Hilde Elisabeth Maria & van Aert, Robbie Cornelis Maria & van Assen, Marcel A. L. M., 2021. "Posterior Probabilities of Effect Sizes and Heterogeneity in Meta-Analysis: An Intuitive Approach of Dealing with Publication Bias," OSF Preprints avkgj, Center for Open Science.
    17. Sesha Kethineni & Susan Frazier‐Kouassi & Yuki Shigemoto & Wesley Jennings & Stephanie M. Cardwell & Alex R. Piquero & Kimberly Gay & Dayanand Sundaravadivelu, 2021. "PROTOCOL: Effectiveness of parent‐engagement programs to reduce truancy and juvenile delinquency: A systematic review," Campbell Systematic Reviews, John Wiley & Sons, vol. 17(3), September.
    18. Charlotte E. Gill & Jordan Hyatt & Lawrence W. Sherman, 2010. "PROTOCOL: Probation Intensity Effects on Probationers' Criminal Conduct," Campbell Systematic Reviews, John Wiley & Sons, vol. 6(1), pages 1-25.
    19. Ritchwood, Tiarney D. & Ford, Haley & DeCoster, Jamie & Sutton, Marnie & Lochman, John E., 2015. "Risky sexual behavior and substance use among adolescents: A meta-analysis," Children and Youth Services Review, Elsevier, vol. 52(C), pages 74-88.
    20. Georgiou, George K. & Guo, Kan & Naveenkumar, Nithya & Vieira, Ana Paula Alves & Das, J.P., 2020. "PASS theory of intelligence and academic achievement: A meta-analytic review," Intelligence, Elsevier, vol. 79(C).

    More about this item

    Statistics

    Access and download statistics

    Corrections

    All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:plo:pone00:0192658. See general information about how to correct material in RePEc.

    If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

    If CitEc recognized a bibliographic reference but did not link an item in RePEc to it, you can help with this form .

    If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.

    For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: plosone (email available below). General contact details of provider: https://journals.plos.org/plosone/ .

    Please note that corrections may take a couple of weeks to filter through the various RePEc services.

    IDEAS is a RePEc service. RePEc uses bibliographic data supplied by the respective publishers.