IDEAS home Printed from https://ideas.repec.org/a/plo/pone00/0176802.html
   My bibliography  Save this article

Caspase polymorphisms and prognosis of hepatocellular carcinoma

Author

Listed:
  • Song Zhang
  • Qianyi Xiao
  • Zhuqing Shi
  • Guopeng Yu
  • Xiao-Pin Ma
  • Haitao Chen
  • Pengyin Zhang
  • Suqin Shen
  • He-Xi Ge Sai-Yin
  • Tao-Yang Chen
  • Pei-Xin Lu
  • Neng-Jin Wang
  • Weihua Ren
  • Peng Huang
  • Jun Xie
  • Carly Conran
  • S Lilly Zheng
  • Long Yu
  • Jianfeng Xu
  • De-Ke Jiang

Abstract

The aim of our study was to determine the impact of genetic polymorphisms in the caspase (CASP) genes on prognosis of hepatocellular carcinoma (HCC). We genotyped 7 potentially functional polymorphisms in CASP3, CASP7, CASP8, CASP9, CASP10 genes in 362 HCC patients of receiving surgical resection of HCC tumor. The associations of genotype and haplotype with overall survival (OS) and disease free survival (DFS) were analyzed by using the Cox proportional hazards model. We found that the CASP9 rs4645981 C allele was significantly associated with positive effect on DFS (P = 0.011 and 0.016 for CT+CC vs. TT in univariate and multivariate analysis, respectively), CT genotype was associated with a better OS of HCC than the TT genotype both in univariate and multivariate analysis (P = 0.048 and 0.041, respectively). Moreover, the CASP3 rs2705897 GT genotype showed marginally significant association with decreased OS and DFS, compared with the GG genotype. One haplotype TT/TG in CASP3 (constructed by rs12108497 T>C and rs2705897 T>G) was significantly associated with decreased OS and DFS, compared to the common haplotype TT/TT both in univariate analysis (P = 0.021 and 0.026, respectively) and multivariate analysis (P = 0.025 and 0.030, respectively). The haplotype GT/GT in CASP9 (constructed by rs4645978 A>G and rs4645981 C>T) was significantly associated with decreased DFS both in univariate and multivariate analysis (P = 0.012 and 0.010, respectively). In conclusion, the CASP9 rs4645981 polymorphism, CASP3 and CASP9 haplotypes may be useful prognosis markers for HCC patients with surgical resection of tumor.

Suggested Citation

  • Song Zhang & Qianyi Xiao & Zhuqing Shi & Guopeng Yu & Xiao-Pin Ma & Haitao Chen & Pengyin Zhang & Suqin Shen & He-Xi Ge Sai-Yin & Tao-Yang Chen & Pei-Xin Lu & Neng-Jin Wang & Weihua Ren & Peng Huang &, 2017. "Caspase polymorphisms and prognosis of hepatocellular carcinoma," PLOS ONE, Public Library of Science, vol. 12(4), pages 1-13, April.
  • Handle: RePEc:plo:pone00:0176802
    DOI: 10.1371/journal.pone.0176802
    as

    Download full text from publisher

    File URL: https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0176802
    Download Restriction: no

    File URL: https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0176802&type=printable
    Download Restriction: no

    File URL: https://libkey.io/10.1371/journal.pone.0176802?utm_source=ideas
    LibKey link: if access is restricted and if your library uses this service, LibKey will redirect you to where you can use your library subscription to access this item
    ---><---

    References listed on IDEAS

    as
    1. Michael O. Hengartner, 2000. "The biochemistry of apoptosis," Nature, Nature, vol. 407(6805), pages 770-776, October.
    2. Gerard I. Evan & Karen H. Vousden, 2001. "Proliferation, cell cycle and apoptosis in cancer," Nature, Nature, vol. 411(6835), pages 342-348, May.
    3. Martin Raff, 1998. "Cell suicide for beginners," Nature, Nature, vol. 396(6707), pages 119-119, November.
    Full references (including those not matched with items on IDEAS)

    Most related items

    These are the items that most often cite the same works as this one and are cited by the same works as this one.
    1. Menchón, S.A. & Condat, C.A., 2011. "Quiescent cells: A natural way to resist chemotherapy," Physica A: Statistical Mechanics and its Applications, Elsevier, vol. 390(20), pages 3354-3361.
    2. Xiao-Ying Wang & Jun-Mei Hao & Qiu-Rong Ren & Hai-Ying Li & Jing-Song Wu & Xiao-Huan Zhu & Jin-Yao Chen & Ya-Nan Wang & Li-Shi Zhang, 2021. "Cytotoxicity and Apoptosis Induced by Chenopodium ambrosioides L. Essential Oil in Human Normal Liver Cell Line L02 via the Endogenous Mitochondrial Pathway Rather Than the Endoplasmic Reticulum Stres," IJERPH, MDPI, vol. 18(14), pages 1-11, July.
    3. Benu George & Pradeep Varathan & T. V. Suchithra, 2020. "Meta-analysis on big data of bioactive compounds from mangrove ecosystem to treat neurodegenerative disease," Scientometrics, Springer;Akadémiai Kiadó, vol. 122(3), pages 1539-1561, March.
    4. Yongzhi Yang & Feng Wang & Chenzhang Shi & Yang Zou & Huanlong Qin & Yanlei Ma, 2012. "Cyclin D1 G870A Polymorphism Contributes to Colorectal Cancer Susceptibility: Evidence from a Systematic Review of 22 Case-Control Studies," PLOS ONE, Public Library of Science, vol. 7(5), pages 1-9, May.
    5. Najeeb Ullah & Hae Young Lee & Muhammad Imran Naseer & Ikram Ullah & Joo Won Suh & Myeong Ok Kim, 2011. "Nicotinamide Inhibits Alkylating Agent-Induced Apoptotic Neurodegeneration in the Developing Rat Brain," PLOS ONE, Public Library of Science, vol. 6(12), pages 1-12, December.
    6. Yi Fu & Robert Kunz & Jianhua Wu & Cheng Dong, 2012. "Study of Local Hydrodynamic Environment in Cell-Substrate Adhesion Using Side-View μPIV Technology," PLOS ONE, Public Library of Science, vol. 7(2), pages 1-13, February.
    7. Oludare Temitope Osuntokun & Olaposi A Omotuyi & Anthonia O Oluduro, 2019. "MazEF homologous Modules System and A Post-segregational killing Mechanism (Bacteriostatic & Bactericidal Mechanism) of Novel Compound Isolated from Spondias monbinon Escherichia Coli and Bacillus Sub," International Journal of Cell Science & Molecular Biology, Juniper Publishers Inc., vol. 5(5), pages 101-109, February.
    8. Richmond, Peter & Roehner, Bertrand M., 2016. "Effect of marital status on death rates. Part 1: High accuracy exploration of the Farr–Bertillon effect," Physica A: Statistical Mechanics and its Applications, Elsevier, vol. 450(C), pages 748-767.
    9. Sukanya Panja & Mihai Ioan Truica & Christina Y. Yu & Vamshi Saggurthi & Michael W. Craige & Katie Whitehead & Mayra V. Tuiche & Aymen Al-Saadi & Riddhi Vyas & Shridar Ganesan & Suril Gohel & Frederic, 2024. "Mechanism-centric regulatory network identifies NME2 and MYC programs as markers of Enzalutamide resistance in CRPC," Nature Communications, Nature, vol. 15(1), pages 1-24, December.
    10. Neha Pal & Shalini Rathore & Priya Kaushik & Swati Tyagi & Abhimanyu Kumar Jha & Anshuman Kumar, 2019. "Promoter Hypermethylation of Apoptotic genes in Oral Squamous Cell Carcinoma," Cancer Therapy & Oncology International Journal, Juniper Publishers Inc., vol. 13(5), pages 103-108, May.
    11. Kenneth L Ho & Heather A Harrington, 2010. "Bistability in Apoptosis by Receptor Clustering," PLOS Computational Biology, Public Library of Science, vol. 6(10), pages 1-9, October.
    12. Giuseppe Genchi & Alessia Carocci & Graziantonio Lauria & Maria Stefania Sinicropi & Alessia Catalano, 2020. "Nickel: Human Health and Environmental Toxicology," IJERPH, MDPI, vol. 17(3), pages 1-21, January.
    13. Jae-Woong Min & Woo Jin Kim & Jeong A Han & Yu-Jin Jung & Kyu-Tae Kim & Woong-Yang Park & Hae-Ock Lee & Sun Shim Choi, 2015. "Identification of Distinct Tumor Subpopulations in Lung Adenocarcinoma via Single-Cell RNA-seq," PLOS ONE, Public Library of Science, vol. 10(8), pages 1-17, August.
    14. Lei Xu & Xin Zhou & Feng Jiang & Man-Tang Qiu & Zhi Zhang & Rong Yin & Lin Xu, 2013. "FASL rs763110 Polymorphism Contributes to Cancer Risk: An Updated Meta-Analysis Involving 43,295 Subjects," PLOS ONE, Public Library of Science, vol. 8(9), pages 1-9, September.
    15. Xishan Li & Chengyan Wang & Nan Li & Yali Gao & Zhonglei Ju & Guoxiang Liao & Deqi Xiong, 2021. "Combined Effects of Elevated Temperature and Crude Oil Pollution on Oxidative Stress and Apoptosis in Sea Cucumber ( Apostichopus japonicus , Selenka)," IJERPH, MDPI, vol. 18(2), pages 1-16, January.
    16. Sougata Roy Chowdhury & Suman Sengupta & Subir Biswas & Tridib Kumar Sinha & Ramkrishna Sen & Ratan Kumar Basak & Basudam Adhikari & Arindam Bhattacharyya, 2014. "Bacterial Fucose-Rich Polysaccharide Stabilizes MAPK-Mediated Nrf2/Keap1 Signaling by Directly Scavenging Reactive Oxygen Species during Hydrogen Peroxide-Induced Apoptosis of Human Lung Fibroblast Ce," PLOS ONE, Public Library of Science, vol. 9(11), pages 1-19, November.
    17. Anthony Szedlak & Spencer Sims & Nicholas Smith & Giovanni Paternostro & Carlo Piermarocchi, 2017. "Cell cycle time series gene expression data encoded as cyclic attractors in Hopfield systems," PLOS Computational Biology, Public Library of Science, vol. 13(11), pages 1-19, November.
    18. Michael Schauperl & Julian E Fuchs & Birgit J Waldner & Roland G Huber & Christian Kramer & Klaus R Liedl, 2015. "Characterizing Protease Specificity: How Many Substrates Do We Need?," PLOS ONE, Public Library of Science, vol. 10(11), pages 1-17, November.
    19. W. Frank Lenoir & Micaela Morgado & Peter C. DeWeirdt & Megan McLaughlin & Audrey L. Griffith & Annabel K. Sangree & Marissa N. Feeley & Nazanin Esmaeili Anvar & Eiru Kim & Lori L. Bertolet & Medina C, 2021. "Discovery of putative tumor suppressors from CRISPR screens reveals rewired lipid metabolism in acute myeloid leukemia cells," Nature Communications, Nature, vol. 12(1), pages 1-15, December.
    20. Jun-Won Heo & Su-Zi Yoo & Mi-Hyun No & Dong-Ho Park & Ju-Hee Kang & Tae-Woon Kim & Chang-Ju Kim & Dae-Yun Seo & Jin Han & Jin-Hwan Yoon & Su-Jeen Jung & Hyo-Bum Kwak, 2018. "Exercise Training Attenuates Obesity-Induced Skeletal Muscle Remodeling and Mitochondria-Mediated Apoptosis in the Skeletal Muscle," IJERPH, MDPI, vol. 15(10), pages 1-12, October.

    More about this item

    Statistics

    Access and download statistics

    Corrections

    All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:plo:pone00:0176802. See general information about how to correct material in RePEc.

    If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

    If CitEc recognized a bibliographic reference but did not link an item in RePEc to it, you can help with this form .

    If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.

    For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: plosone (email available below). General contact details of provider: https://journals.plos.org/plosone/ .

    Please note that corrections may take a couple of weeks to filter through the various RePEc services.

    IDEAS is a RePEc service. RePEc uses bibliographic data supplied by the respective publishers.