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The biochemistry of apoptosis

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  • Michael O. Hengartner

    (Cold Spring Harbor Laboratory)

Abstract

Apoptosis — the regulated destruction of a cell — is a complicated process. The decision to die cannot be taken lightly, and the activity of many genes influence a cell's likelihood of activating its self-destruction programme. Once the decision is taken, proper execution of the apoptotic programme requires the coordinated activation and execution of multiple subprogrammes. Here I review the basic components of the death machinery, describe how they interact to regulate apoptosis in a coordinated manner, and discuss the main pathways that are used to activate cell death.

Suggested Citation

  • Michael O. Hengartner, 2000. "The biochemistry of apoptosis," Nature, Nature, vol. 407(6805), pages 770-776, October.
    • Handle: RePEc:nat:nature:v:407:y:2000:i:6805:d:10.1038_35037710
    DOI: 10.1038/35037710
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    Cited by:

    1. Giuseppe Genchi & Alessia Carocci & Graziantonio Lauria & Maria Stefania Sinicropi & Alessia Catalano, 2020. "Nickel: Human Health and Environmental Toxicology," IJERPH, MDPI, vol. 17(3), pages 1-21, January.
    2. Jun-Won Heo & Su-Zi Yoo & Mi-Hyun No & Dong-Ho Park & Ju-Hee Kang & Tae-Woon Kim & Chang-Ju Kim & Dae-Yun Seo & Jin Han & Jin-Hwan Yoon & Su-Jeen Jung & Hyo-Bum Kwak, 2018. "Exercise Training Attenuates Obesity-Induced Skeletal Muscle Remodeling and Mitochondria-Mediated Apoptosis in the Skeletal Muscle," IJERPH, MDPI, vol. 15(10), pages 1-12, October.
    3. Najeeb Ullah & Hae Young Lee & Muhammad Imran Naseer & Ikram Ullah & Joo Won Suh & Myeong Ok Kim, 2011. "Nicotinamide Inhibits Alkylating Agent-Induced Apoptotic Neurodegeneration in the Developing Rat Brain," PLOS ONE, Public Library of Science, vol. 6(12), pages 1-12, December.
    4. Xiao-Ying Wang & Jun-Mei Hao & Qiu-Rong Ren & Hai-Ying Li & Jing-Song Wu & Xiao-Huan Zhu & Jin-Yao Chen & Ya-Nan Wang & Li-Shi Zhang, 2021. "Cytotoxicity and Apoptosis Induced by Chenopodium ambrosioides L. Essential Oil in Human Normal Liver Cell Line L02 via the Endogenous Mitochondrial Pathway Rather Than the Endoplasmic Reticulum Stres," IJERPH, MDPI, vol. 18(14), pages 1-11, July.
    5. Benu George & Pradeep Varathan & T. V. Suchithra, 2020. "Meta-analysis on big data of bioactive compounds from mangrove ecosystem to treat neurodegenerative disease," Scientometrics, Springer;Akadémiai Kiadó, vol. 122(3), pages 1539-1561, March.
    6. Shi-ming Li & Dan Liu & Yi-lin Liu & Bin Liu & Xing-huang Chen, 2020. "Quercetin and Its Mixture Increase the Stress Resistance of Caenorhabditis elegans to UV-B," IJERPH, MDPI, vol. 17(5), pages 1-13, February.
    7. Yue Wang & Sheng-Yuan Wang & Li Jia & Lin Zhang & Jing-Chong Ba & Dan Han & Cui-Ping Yu & Yong-Hui Wu, 2016. "Nickel-Refining Fumes Induced DNA Damage and Apoptosis of NIH/3T3 Cells via Oxidative Stress," IJERPH, MDPI, vol. 13(7), pages 1-15, June.
    8. Song Zhang & Qianyi Xiao & Zhuqing Shi & Guopeng Yu & Xiao-Pin Ma & Haitao Chen & Pengyin Zhang & Suqin Shen & He-Xi Ge Sai-Yin & Tao-Yang Chen & Pei-Xin Lu & Neng-Jin Wang & Weihua Ren & Peng Huang &, 2017. "Caspase polymorphisms and prognosis of hepatocellular carcinoma," PLOS ONE, Public Library of Science, vol. 12(4), pages 1-13, April.
    9. Xishan Li & Chengyan Wang & Nan Li & Yali Gao & Zhonglei Ju & Guoxiang Liao & Deqi Xiong, 2021. "Combined Effects of Elevated Temperature and Crude Oil Pollution on Oxidative Stress and Apoptosis in Sea Cucumber ( Apostichopus japonicus , Selenka)," IJERPH, MDPI, vol. 18(2), pages 1-16, January.
    10. Michael Schauperl & Julian E Fuchs & Birgit J Waldner & Roland G Huber & Christian Kramer & Klaus R Liedl, 2015. "Characterizing Protease Specificity: How Many Substrates Do We Need?," PLOS ONE, Public Library of Science, vol. 10(11), pages 1-17, November.
    11. Sougata Roy Chowdhury & Suman Sengupta & Subir Biswas & Tridib Kumar Sinha & Ramkrishna Sen & Ratan Kumar Basak & Basudam Adhikari & Arindam Bhattacharyya, 2014. "Bacterial Fucose-Rich Polysaccharide Stabilizes MAPK-Mediated Nrf2/Keap1 Signaling by Directly Scavenging Reactive Oxygen Species during Hydrogen Peroxide-Induced Apoptosis of Human Lung Fibroblast Ce," PLOS ONE, Public Library of Science, vol. 9(11), pages 1-19, November.

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