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Promoter Hypermethylation of Apoptotic genes in Oral Squamous Cell Carcinoma

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  • Neha Pal

    (Department of Biotechnology, Faculty of Life Sciences, Institute of Applied Medicines and Research, Ghaziabad, Uttar Pradesh, India)

  • Shalini Rathore

    (Department of Biotechnology, Faculty of Life Sciences, Institute of Applied Medicines and Research, Ghaziabad, Uttar Pradesh, India)

  • Priya Kaushik

    (Department of Biotechnology, Faculty of Life Sciences, Institute of Applied Medicines and Research, Ghaziabad, Uttar Pradesh, India)

  • Swati Tyagi

    (Department of Biotechnology, Faculty of Life Sciences, Institute of Applied Medicines and Research, Ghaziabad, Uttar Pradesh, India)

  • Abhimanyu Kumar Jha

    (Department of Biotechnology, Faculty of Life Sciences, Institute of Applied Medicines and Research, Ghaziabad, Uttar Pradesh, India)

  • Anshuman Kumar

    (Director, Surgical Oncology, Dharamshila Narayana Super speciality Hospital, Delhi, India)

Abstract

Cancer is one of those diseases whose treatment requires more rapid and potent response and epigenetic modifications have emerged one amongst the cancer hallmarks, commutating the concept of malignant pathologies as being singlely genetic-based conditions. Oral Cancer is the type of malignancy that is found in any area of mouth and nearby regions. The epigenetic landscape is accountable for traditional development however additionally for the non uniformity among tissues in terms of gene expression patterns. Dysregulation in these mechanisms has been related to illness stage, and raised attention is currently granted to cancer so as to require advantage of those modifications in terms of novel therapeutic methods or diagnosis/prognosis tools. Epigenetics has revealed a diagnostic tool that is tumour markers which is also known as biomarkers. These biomarkers are either methylated at their CpG islands called as DNA hypermethylation or another modification could be possibly observed that would help us to identify the neoplasm for its medication because it is usually symptomless at its beginning stages. This review encompasses the different apoptotic genes that have been found as a biomarker for diagnosing the OSCC (Oral Squamous Cell Carcinoma) and how they are related to epigenetics. This can hold an immense importance in the treatment of cancer and could help in discovering novel therapeutic ways in its treatment.

Suggested Citation

  • Neha Pal & Shalini Rathore & Priya Kaushik & Swati Tyagi & Abhimanyu Kumar Jha & Anshuman Kumar, 2019. "Promoter Hypermethylation of Apoptotic genes in Oral Squamous Cell Carcinoma," Cancer Therapy & Oncology International Journal, Juniper Publishers Inc., vol. 13(5), pages 103-108, May.
    • Handle: RePEc:adp:jctoij:v:13:y:2019:i:5:p:103-108
    DOI: 10.19080/CTOIJ.2019.13.555872
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    References listed on IDEAS

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    1. Gerard I. Evan & Karen H. Vousden, 2001. "Proliferation, cell cycle and apoptosis in cancer," Nature, Nature, vol. 411(6835), pages 342-348, May.
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